Compound_ID |
Target |
Gene_Name |
Gene_ID |
Cancer |
Cell_lines |
IC50 Value |
EC50 Value |
ED50 Value |
GI50 Value |
Remarks |
References |
MMP-AC0207 |
COX-1 |
cytochrome c oxidase subunit I |
4512 |
Breast adenocarcinoma |
MCF-7 |
- |
- |
- |
- |
Peonidin, which have methoxyl substituents in their B ring, showed 39.6% COX-1 inhibitory activities. |
12925310 |
MMP-AC0207 |
COX-1 |
cytochrome c oxidase subunit I |
4512 |
Breast adenocarcinoma |
MCF-7 |
- |
- |
- |
- |
Peonidin, which have methoxyl substituents in their B ring, showed 39.6% COX-1 inhibitory activities. |
12925310 |
MMP-AC0207 |
COX-1 |
cytochrome c oxidase subunit I |
4512 |
CNS Cancer |
SF-268 |
- |
- |
- |
- |
Peonidin, which have methoxyl substituents in their B ring, showed 39.6% COX-1 inhibitory activities. |
12925310 |
MMP-AC0207 |
COX-1 |
cytochrome c oxidase subunit I |
4512 |
Colon cancer |
HCT-116 |
- |
- |
- |
- |
Peonidin, which have methoxyl substituents in their B ring, showed 39.6% COX-1 inhibitory activities. |
12925310 |
MMP-AC0207 |
COX-1 |
cytochrome c oxidase subunit I |
4512 |
Non-small cell lung cancer |
NCl-H460 |
- |
- |
- |
- |
Peonidin, which have methoxyl substituents in their B ring, showed 39.6% COX-1 inhibitory activities. |
12925310 |
MMP-AC0207 |
COX-2 |
cytochrome c oxidase subunit II |
4513 |
Breast adenocarcinoma |
MCF-7 |
- |
- |
- |
- |
Peonidin , which have methoxyl substituents in their B ring, showed 49.1% COX-2 inhibitory activities. |
12925310 |
MMP-AC0207 |
COX-2 |
cytochrome c oxidase subunit II |
4513 |
CNS Cancer |
SF-268 |
- |
- |
- |
- |
Peonidin , which have methoxyl substituents in their B ring, showed 49.1% COX-2 inhibitory activities. |
12925310 |
MMP-AC0207 |
COX-2 |
cytochrome c oxidase subunit II |
4513 |
Colon cancer |
HCT-116 |
- |
- |
- |
- |
Peonidin , which have methoxyl substituents in their B ring, showed 49.1% COX-2 inhibitory activities. |
12925310 |
MMP-AC0207 |
COX-2 |
cytochrome c oxidase subunit II |
4513 |
Non-small cell lung cancer |
NCl-H460 |
- |
- |
- |
- |
Peonidin , which have methoxyl substituents in their B ring, showed 49.1% COX-2 inhibitory activities. |
12925310 |
MMP-AC0207 |
COX-2 |
cytochrome c oxidase subunit II |
4513 |
Mouse Epidermal |
JB6 P+ |
- |
- |
- |
- |
They evaluated the ability of peonidin to inhibit TPA-induced COX-2 expression in JB6 P+ cells, and found that peonidin suppressed the expression of COX-2 in a concentration-dependent manner. |
17404064 |
MMP-AC0207 |
MAPK1 |
mitogen-activated protein kinase 1 |
5594 |
Mouse Epidermal |
JB6 P+ |
- |
- |
- |
- |
It was found that TPA strongly induced phosphorylation of ERK-2 in JB6 P+ cells, and that this was blocked by 20 µM peonidin. |
17404064 |
MMP-AC0207 |
MAPK3 |
mitogen-activated protein kinase 3 |
5595 |
Mouse Epidermal |
JB6 P+ |
- |
- |
- |
- |
It was found that TPA strongly induced phosphorylation of ERK-1 in JB6 P+ cells, and that this was blocked by 20 µM peonidin. |
17404064 |