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Botanical Name Plant's Common Name Plant Family   

   MMP-AC0181 : Epigallocatechin gallate

 
Compound Name  :
Epigallocatechin gallate		  
  Compound Class  : Flavonoid  
  Synonyms  : (-)-Epigallocatechin gallate; EGCG; 989-51-5; Epigallocatechin gallate; Epigallocatechin 3-gallate;

  
  Compound Extracted from  : Epigallocatechin gallate is extracted / reported from 1 Plant(s) of Melghat Flora as below


 
 
Molecular Formula  :
C22H18O11		  
  Molecular Weight  : 458.4  
  InChi Key  :  
  IUPAC  :  
  InChi  :  
  Hydrogen Bond Donor count  : 8  
  Hydrogen Bond Acceptor count  : 11  
  Rotational Bond count  : 4  
  TPSA  : 197  
  LogP Value  :

 1.2

  
 
Lipinski Rule of Five  :
No		  
  Ghose Filter  : Yes  
  Veber Filter  : No  
  Muegge Filter  :

 No

  
 
PubChem CID  :
65064		  
  Drugbank ID  : DB12116  
  Super Natural  : 000989515  
  CTD  : C045651  
  HIT  : -  
  NCI-60 GI50 data  :

 -

  
 
Reference(s)  :
https://pubchem.ncbi.nlm.nih.gov/compound/65064

  

Compound_ID Cell Lines Cancer Type IC50 Value EC50 Value ED50 Value GI50 Value References
MMP-AC0181 HL-60 Haematopoietic and Lymphoid tissue >100 然 - - - 12628514
MMP-AC0181 Hepa 1c1c7 Liver >50 然 - - - 12628514
MMP-AC0181 A549 Lung 49 然 - - - 21111588
MMP-AC0181 H1975 Lung 10.2 然ol/L - - - 19638461
MMP-AC0181 H-358 Lung 26.4 然ol/L - - - 19638461
MMP-AC0181 H-460 Lung 22.1 然ol/L - - - 19638461

Compound_ID Target Gene_Name Gene_ID Cancer Cell_lines IC50 Value EC50 Value ED50 Value GI50 Value Remarks References
MMP-AC0181 CASP3 Caspase 3, apoptosis-related cysteine peptidase 836 Colon Cancer HT-29 - - - - After the treatments of different doses of Epigallocatechin gallate (EGCG) , the induction of caspase-3 activity in HT-29 cells was consistent with the results shown in DAPI staining and DNA fragmentation experiments. 100 mM of EGCG led to ~8-fold induction of caspase-3 activity after 24 h treatment. 12819184
MMP-AC0181 CASP9 caspase 9, apoptosis-related cysteine peptidase 842 Colon Cancer HT-29 - - - - During the 24 h period, the activity of caspase-9 was consistently increased with the treatment of Epigallocatechin gallate (EGCG). 12819184
MMP-AC0181 MAPK1 mitogen-activated protein kinase 1 5594 Colon Cancer HT-29 - - - - ERK was phosphorylated and activated time-dependently in HT-29 cells after Epigallocatechin gallate (EGCG) treatments. 12819184
MMP-AC0181 MAPK1 mitogen-activated protein kinase 1 5594 Colon Cancer HT-29 - - - - p38 was phosphorylated and activated time-dependently in HT-29 cells after EpigallMAPK8ocatechin gallate (EGCG) treatments. 12819184
MMP-AC0181 MAPK8 mitogen-activated protein kinase 8 5599 Colon Cancer HT-29 - - - - JNK was phosphorylated and activated time-dependently in HT-29 cells after Epigallocatechin gallate (EGCG) treatments 12819184
MMP-AC0181 PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit 5564 Colon Cancer HT-29 - - - - EGCG activated AMPK in a dose-dependent manner as shown by the increased phosphorylation of ACC (acetyl-CoA carboxylase) and the elevation of AMPK expression. 16797120
MMP-AC0181 SLC2A1 Solute carrier family 2 6513 Colon Cancer HT-29 - - - - Epigallocatechin gallate distinctively reduced mRNA levels of Glut-1 16797120
MMP-AC0181 VEGFA Vascular endothelial growth factor A 7422 Colon Cancer HT-29 - - - - Epigallocatechin gallate distinctively reduced mRNA levels of VEGF genes. 16797120