HOME
BROWSE
FLORA
CONTACT
Botanical Name Plant's Common Name Plant Family   

   MMP-AC0212 : Plumbagin

 
Compound Name  :
Plumbagin		  
  Compound Class  : Polycyclic aromatic natural product  
  Synonyms  : 2-methyl-5-hydroxy-1,4-naphthoquinone; 5-hydroxy-2-methyl-1,4-naphthoquinone; plumbagin

  
  Compound Extracted from  : Plumbagin is extracted / reported from 2 Plant(s) of Melghat Flora as below


 
 
Molecular Formula  :
C11H8O3		  
  Molecular Weight  : 188.18  
  InChi Key  :  
  IUPAC  :  
  InChi  :  
  Hydrogen Bond Donor count  : 1  
  Hydrogen Bond Acceptor count  : 3  
  Rotational Bond count  : 0  
  TPSA  : 54.4  
  LogP Value  :

 2.3

  
 
Lipinski Rule of Five  :
Yes		  
  Ghose Filter  : Yes  
  Veber Filter  : Yes  
  Muegge Filter  :

 No

  
 
PubChem CID  :
10205		  
  Drugbank ID  : DB17048  
  Super Natural  : 000481425  
  CTD  : C014758  
  HIT  : C0573  
  NCI-60 GI50 data  :

 481-42-5

  
 
Reference(s)  :
https://pubchem.ncbi.nlm.nih.gov/compound/10205

  

Compound_ID Cell Lines Cancer Type IC50 Value EC50 Value ED50 Value GI50 Value References
MMP-AC0212 HCT-15 Colon 22.5 µM - - - 21559086
MMP-AC0212 HT-29 Colon 62.5 µM - - - 21559086
MMP-AC0212 A-431 Skin 25 µM - - - 19505895

Compound_ID Target Gene_Name Gene_ID Cancer Cell_lines IC50 Value EC50 Value ED50 Value GI50 Value Remarks References
MMP-AC0212 AKT1 v-akt murine thymoma viral oncogene homolog 1 207 Breast Carcinoma MDA-MB-231 - - - - Results show that plumbagin targets the AKT signaling pathway. It can be firmly concluded that plumbagin induces autophagic cell death in MDA-MB-231 by suppression of the AKT pathway. 17172425
MMP-AC0212 AKT1 v-akt murine thymoma viral oncogene homolog 1 207 Breast cancer MDA-MB-231 - - - - Tumor growth inhibition was most evident in mice treated with plumbagin at 2 mg/kg/d, where an nearly 70% reduction in tumor size was observed. Decreases of phospho-AKT was observed in the tumors of the plumbagin-treated mice in comparison with the tumors of vehicle-treated mice. Tumor growth inhibition was most evident in mice treated with plumbagin at 2 mg/kg/d, where an nearly 70% reduction in tumor size was observed. Decreases of phospho-AKT was observed in the tumors of the plumbagin-treated mice in comparison with the tumors of vehicle-treated mice.
MMP-AC0212 BCL2 B-cell CLL/lymphoma 2 596 Breast Carcinoma MDA-MB-231 - - - - MDA-MB-231 cells treated with increasing concentrations of plumbagin for 24 and 72 h showed down-regulation of anti-apoptotic protein Bcl-2. 18980240
MMP-AC0212 BCL2 B-cell CLL/lymphoma 2 596 Breast adenocarcinoma MCF-7 - - - - Plumbagin-Induced Apoptosis of human breast cancer cells s mediated by inactivation of Bcl-. 18980240
MMP-AC0212 CASP3 caspase 3, apoptosis-related cysteine peptidase 836 Epidermoid cervical carcinoma ME-180 - - - - There was a 2.5-fold increase in the caspase-3 activation on treatment with plumbagin. 15264212
MMP-AC0212 MTOR mechanistic target of rapamycin (serine/threonine kinase) 2475 Breast cancer MDA-MB-231 - - - - Tumor growth inhibition was most evident in mice treated with plumbagin at 2 mg/kg/d, where an nearly 70% reduction in tumor size was observed. The levels of phospho-mTOR were lower in the tumors from the plumbagin-treated group when compared with the tumors from vehicle-treated mice. 17172425
MMP-AC0212 NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 4790 Breast adenocarcinoma MCF-7 - - - - Induction of apoptosis in breast cancer cells by plumbagin could be mechanistically linked with the inactivation of NF-k. 18980240
MMP-AC0212 NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 4790 Breast Carcinoma MDA-MB-231 - - - - Induction of apoptosis in breast cancer cells by plumbagin could be mechanistically linked with the inactivation of NF-k. 18980240
MMP-AC0212 PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 5290 Breast Carcinoma MDA-MB-231 - - - - Plumbagin treatment of cells was found to cause a significant reduction in the expression of the regulatory subunit of PI3K (p85) protei. 17172425
MMP-AC0212 PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 5290 Breast cancer MDA-MB-231 - - - - Tumor growth inhibition was most evident in mice treated with plumbagin at 2 mg/kg/d, where an nearly 70% reduction in tumor size was observed. Decreases of PI3K (p85) regulatory subunit was observed in the tumors of the plumbagin-treated mice in comparison with the tumors of vehicle-treated mice 17172425