Compound_ID |
Target |
Gene_Name |
Gene_ID |
Cancer |
Cell_lines |
IC50 Value |
EC50 Value |
ED50 Value |
GI50 Value |
Remarks |
References |
MMP-AC0001 |
AURKB |
aurora kinase B |
9212 |
Colon Cancer |
SW-620 |
- |
- |
- |
- |
Squamocin, isolated from several genera of the plant family Annonaceae, which decreased (m)RNA expression levels of MSK1 in cancer cells and decreased the phosphorylated MSK1 (pMSK1). |
21299907 |
MMP-AC0001 |
AURKB |
aurora kinase B |
9212 |
Human Glioblastoma Multiforme |
GBM8401 |
- |
- |
- |
- |
Squamocin, isolated from several genera of the plant family Annonaceae, which decreased (m)RNA expression levels of MSK1 in cancer cells and decreased the phosphorylated MSK1 (pMSK1). |
21299907 |
MMP-AC0001 |
AURKB |
aurora kinase B |
9212 |
Liver Cancer |
HUH7 |
- |
- |
- |
- |
Squamocin, isolated from several genera of the plant family Annonaceae, which decreased (m)RNA expression levels of MSK1 in cancer cells and decreased the phosphorylated MSK1 (pMSK1). |
21299907 |
MMP-AC0001 |
BAD |
BCL2-associated agonist of cell death |
572 |
Bladder Cancer |
T24 |
- |
- |
- |
- |
Squamocin significantly enhanced the expression of Bad at 1, 4, 8, 12, and 24 h after treatment. |
16154156 |
MMP-AC0001 |
BAX |
BCL2-associated X protein |
581 |
Bladder Cancer |
T24 |
- |
- |
- |
- |
Squamocin significantly enhanced the expression of Bax at 1, 4, 8, 12, and 24 h after treatment. |
16154156 |
MMP-AC0001 |
CASP3 |
caspase 3, apoptosis-related cysteine peptidase |
836 |
Colon cancer |
SW-620 |
- |
- |
- |
- |
Squamocin enhanced caspase-3 activities and cause apoptosis. |
21299907 |
MMP-AC0001 |
CASP3 |
caspase 3, apoptosis-related cysteine peptidase |
836 |
Human Glioblastoma Multiforme |
GBM8401 |
- |
- |
- |
- |
Squamocin enhanced caspase-3 activities and cause apoptosis. |
21299907 |
MMP-AC0001 |
CASP3 |
caspase 3, apoptosis-related cysteine peptidase |
836 |
Liver Cancer |
HUH7 |
- |
- |
- |
- |
Squamocin enhanced caspase-3 activities and cause apoptosis. |
21299907 |
MMP-AC0001 |
CASP3 |
caspase 3, apoptosis-related cysteine peptidase |
836 |
Bladder Cancer |
T24 |
- |
- |
- |
- |
The expression of procaspase-3 was induced by 10 µg/mL of squamocin at 1 h and greater time points via cleavage. |
16154156 |
MMP-AC0001 |
CASP8 |
caspase 8, apoptosis-related cysteine peptidase |
841 |
Colon Cancer |
SW-620 |
- |
- |
- |
- |
Squamocin enhanced caspase-8 activities and cause apoptosis. |
21299907 |
MMP-AC0001 |
CASP8 |
caspase 8, apoptosis-related cysteine peptidase |
841 |
Human Glioblastoma Multiforme |
GBM8401 |
- |
- |
- |
- |
Squamocin enhanced caspase-8 activities and cause apoptosis. |
21299907 |
MMP-AC0001 |
CASP8 |
caspase 8, apoptosis-related cysteine peptidase |
841 |
Liver Cancer |
HUH7 |
- |
- |
- |
- |
Squamocin enhanced caspase-8 activities and cause apoptosis. |
21299907 |
MMP-AC0001 |
CASP9 |
caspase 9, apoptosis-related cysteine peptidase |
842 |
Colon Cancer |
SW-620 |
- |
- |
- |
- |
Squamocin enhanced caspase-9 activities and cause apoptosis. |
21299907 |
MMP-AC0001 |
CASP9 |
caspase 9, apoptosis-related cysteine peptidase |
842 |
Human Glioblastoma Multiforme |
GBM8401 |
- |
- |
- |
- |
Squamocin enhanced caspase-9 activities and cause apoptosis. |
21299907 |
MMP-AC0001 |
CASP9 |
caspase 9, apoptosis-related cysteine peptidase |
842 |
Liver Cancer |
HUH7 |
- |
- |
- |
- |
Squamocin enhanced caspase-9 activities and cause apoptosis. |
21299907 |
MMP-AC0001 |
MAPK1 |
Mitogen-activated protein kinase 1 |
5594 |
Colon Cancer |
SW-620 |
- |
- |
- |
- |
Squamocin treatment significantly decreased ERK phosphorylation (pERK) levels and ERK is connected to cell survival. |
21299907 |
MMP-AC0001 |
MAPK1 |
Mitogen-activated protein kinase 1 |
5594 |
Human Glioblastoma Multiforme |
GBM8401 |
- |
- |
- |
- |
Squamocin treatment significantly decreased ERK phosphorylation (pERK) levels and ERK is connected to cell survival. |
21299907 |
MMP-AC0001 |
MAPK1 |
Mitogen-activated protein kinase 1 |
5594 |
Liver Cancer |
HUH7 |
- |
- |
- |
- |
Squamocin treatment significantly decreased ERK phosphorylation (pERK) levels and ERK is connected to cell survival. |
21299907 |
MMP-AC0001 |
MAPK8 |
mitogen-activated protein kinase 8 |
5599 |
Colon Cancer |
SW-620 |
- |
- |
- |
- |
squamocin treatment significantly increased JNK phosphorylation (pJNK) levels. It was determined that activation of JNK affects members of the Bcl-2 family and activates caspases which results in apoptosis. |
21299907 |
MMP-AC0001 |
MAPK8 |
mitogen-activated protein kinase 8 |
5599 |
Human Glioblastoma Multiforme |
GBM8401 |
- |
- |
- |
- |
squamocin treatment significantly increased JNK phosphorylation (pJNK) levels. It was determined that activation of JNK affects members of the Bcl-2 family and activates caspases which results in apoptosis. |
21299907 |
MMP-AC0001 |
MAPK8 |
mitogen-activated protein kinase 8 |
5599 |
Liver Cancer |
HUH7 |
- |
- |
- |
- |
squamocin treatment significantly increased JNK phosphorylation (pJNK) levels. It was determined that activation of JNK affects members of the Bcl-2 family and activates caspases which results in apoptosis. |
21299907 |
MMP-AC0001 |
PARP1 |
poly (ADP-ribose) polymerase 1 |
142 |
Bladder Cancer |
T24 |
- |
- |
- |
- |
The function of PARP was destroyed by 10 µg/mL of squamocin at 1 h and greater time points via cleavage. |
16154156 |
MMP-AC0001 |
RPS6KA5 |
ribosomal protein S6 kinase, 90kDa, polypeptide 5 |
9252 |
Colon Cancer |
SW-620 |
- |
- |
- |
- |
Squamocin, isolated from several genera of the plant family Annonaceae, which decreased (m)RNA expression levels of Aurora B in cancer cells and decreased the protein expression levels of aurora . |
21299907 |
MMP-AC0001 |
RPS6KA5 |
ribosomal protein S6 kinase, 90kDa, polypeptide 5 |
9252 |
Human Glioblastoma Multiforme |
GBM8401 |
- |
- |
- |
- |
Squamocin, isolated from several genera of the plant family Annonaceae, which decreased (m)RNA expression levels of Aurora B in cancer cells and decreased the protein expression levels of aurora . |
21299907 |
MMP-AC0001 |
RPS6KA5 |
ribosomal protein S6 kinase, 90kDa, polypeptide 5 |
9252 |
Liver Cancer |
HUH7 |
- |
- |
- |
- |
Squamocin, isolated from several genera of the plant family Annonaceae, which decreased (m)RNA expression levels of Aurora B in cancer cells and decreased the protein expression levels of aurora . |
21299907 |