Botanical Name Plant's Common Name Plant Family   

   MMP-AC0001 : Squamocin

 
Compound Name  :

Squamocin
 
  Compound Class  : Polyketides  
  Synonyms  : Squamocin; Annonin I; CHEMBL41177; CHEBI:9246; 120298-30-8; Squamocin A

 
  Compound Extracted from  : Squamocin is extracted / reported from 1 Plant(s) of Melghat Flora as below


 
 
Molecular Formula  :

C37H66O7
 
  Molecular Weight  : 622.928  
  InChi Key  :  
  IUPAC  :  
  InChi  :  
  Hydrogen Bond Donor count  : 3  
  Hydrogen Bond Acceptor count  : 7  
  Rotational Bond count  : 25  
  TPSA  : 105  
  LogP Value  :

9.5

 
 
Lipinski Rule of Five  :

No
 
  Ghose Filter  : No  
  Veber Filter  : No  
  Muegge Filter  :

No

 
 
PubChem CID  :

441612
 
  Drugbank ID  : -  
  Super Natural  : 120298308  
  CTD  : C059660  
  HIT  : -  
  NCI-60 GI50 data  :

-

 
 
Reference(s)  :



 

Compound_ID Cell Lines Cancer Type IC50 Value EC50 Value ED50 Value GI50 Value References
MMP-AC0001 MCF-7 Breast 0.0005 µM - - - 19285863
MMP-AC0001 HeLa Cervix 0.0097 µM - - - 19285863
MMP-AC0001 Hep G2 Liver 5.47x10-4 - - - 12677528
MMP-AC0001 SMMC-7541 Liver 0.00009 µM - - - 19285863
MMP-AC0001 A-5408 Lung 0.00087 µM - - - 19285863
MMP-AC0001 KB Nasopharyngeal - - 0.0004 µg/ - 9461649
MMP-AC0001 SGC-7901 Stomach 0.00073 µM - - - 19285863

Compound_ID Target Gene_Name Gene_ID Cancer Cell_lines IC50 Value EC50 Value ED50 Value GI50 Value Remarks References
MMP-AC0001 AURKB aurora kinase B 9212 Colon Cancer SW-620 - - - - Squamocin, isolated from several genera of the plant family Annonaceae, which decreased (m)RNA expression levels of MSK1 in cancer cells and decreased the phosphorylated MSK1 (pMSK1). 21299907
MMP-AC0001 AURKB aurora kinase B 9212 Human Glioblastoma Multiforme GBM8401 - - - - Squamocin, isolated from several genera of the plant family Annonaceae, which decreased (m)RNA expression levels of MSK1 in cancer cells and decreased the phosphorylated MSK1 (pMSK1). 21299907
MMP-AC0001 AURKB aurora kinase B 9212 Liver Cancer HUH7 - - - - Squamocin, isolated from several genera of the plant family Annonaceae, which decreased (m)RNA expression levels of MSK1 in cancer cells and decreased the phosphorylated MSK1 (pMSK1). 21299907
MMP-AC0001 BAD BCL2-associated agonist of cell death 572 Bladder Cancer T24 - - - - Squamocin significantly enhanced the expression of Bad at 1, 4, 8, 12, and 24 h after treatment. 16154156
MMP-AC0001 BAX BCL2-associated X protein 581 Bladder Cancer T24 - - - - Squamocin significantly enhanced the expression of Bax at 1, 4, 8, 12, and 24 h after treatment. 16154156
MMP-AC0001 CASP3 caspase 3, apoptosis-related cysteine peptidase 836 Colon cancer SW-620 - - - - Squamocin enhanced caspase-3 activities and cause apoptosis. 21299907
MMP-AC0001 CASP3 caspase 3, apoptosis-related cysteine peptidase 836 Human Glioblastoma Multiforme GBM8401 - - - - Squamocin enhanced caspase-3 activities and cause apoptosis. 21299907
MMP-AC0001 CASP3 caspase 3, apoptosis-related cysteine peptidase 836 Liver Cancer HUH7 - - - - Squamocin enhanced caspase-3 activities and cause apoptosis. 21299907
MMP-AC0001 CASP3 caspase 3, apoptosis-related cysteine peptidase 836 Bladder Cancer T24 - - - - The expression of procaspase-3 was induced by 10 g/mL of squamocin at 1 h and greater time points via cleavage. 16154156
MMP-AC0001 CASP8 caspase 8, apoptosis-related cysteine peptidase 841 Colon Cancer SW-620 - - - - Squamocin enhanced caspase-8 activities and cause apoptosis. 21299907
MMP-AC0001 CASP8 caspase 8, apoptosis-related cysteine peptidase 841 Human Glioblastoma Multiforme GBM8401 - - - - Squamocin enhanced caspase-8 activities and cause apoptosis. 21299907
MMP-AC0001 CASP8 caspase 8, apoptosis-related cysteine peptidase 841 Liver Cancer HUH7 - - - - Squamocin enhanced caspase-8 activities and cause apoptosis. 21299907
MMP-AC0001 CASP9 caspase 9, apoptosis-related cysteine peptidase 842 Colon Cancer SW-620 - - - - Squamocin enhanced caspase-9 activities and cause apoptosis. 21299907
MMP-AC0001 CASP9 caspase 9, apoptosis-related cysteine peptidase 842 Human Glioblastoma Multiforme GBM8401 - - - - Squamocin enhanced caspase-9 activities and cause apoptosis. 21299907
MMP-AC0001 CASP9 caspase 9, apoptosis-related cysteine peptidase 842 Liver Cancer HUH7 - - - - Squamocin enhanced caspase-9 activities and cause apoptosis. 21299907
MMP-AC0001 MAPK1 Mitogen-activated protein kinase 1 5594 Colon Cancer SW-620 - - - - Squamocin treatment significantly decreased ERK phosphorylation (pERK) levels and ERK is connected to cell survival. 21299907
MMP-AC0001 MAPK1 Mitogen-activated protein kinase 1 5594 Human Glioblastoma Multiforme GBM8401 - - - - Squamocin treatment significantly decreased ERK phosphorylation (pERK) levels and ERK is connected to cell survival. 21299907
MMP-AC0001 MAPK1 Mitogen-activated protein kinase 1 5594 Liver Cancer HUH7 - - - - Squamocin treatment significantly decreased ERK phosphorylation (pERK) levels and ERK is connected to cell survival. 21299907
MMP-AC0001 MAPK8 mitogen-activated protein kinase 8 5599 Colon Cancer SW-620 - - - - squamocin treatment significantly increased JNK phosphorylation (pJNK) levels. It was determined that activation of JNK affects members of the Bcl-2 family and activates caspases which results in apoptosis. 21299907
MMP-AC0001 MAPK8 mitogen-activated protein kinase 8 5599 Human Glioblastoma Multiforme GBM8401 - - - - squamocin treatment significantly increased JNK phosphorylation (pJNK) levels. It was determined that activation of JNK affects members of the Bcl-2 family and activates caspases which results in apoptosis. 21299907
MMP-AC0001 MAPK8 mitogen-activated protein kinase 8 5599 Liver Cancer HUH7 - - - - squamocin treatment significantly increased JNK phosphorylation (pJNK) levels. It was determined that activation of JNK affects members of the Bcl-2 family and activates caspases which results in apoptosis. 21299907
MMP-AC0001 PARP1 poly (ADP-ribose) polymerase 1 142 Bladder Cancer T24 - - - - The function of PARP was destroyed by 10 g/mL of squamocin at 1 h and greater time points via cleavage. 16154156
MMP-AC0001 RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 9252 Colon Cancer SW-620 - - - - Squamocin, isolated from several genera of the plant family Annonaceae, which decreased (m)RNA expression levels of Aurora B in cancer cells and decreased the protein expression levels of aurora . 21299907
MMP-AC0001 RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 9252 Human Glioblastoma Multiforme GBM8401 - - - - Squamocin, isolated from several genera of the plant family Annonaceae, which decreased (m)RNA expression levels of Aurora B in cancer cells and decreased the protein expression levels of aurora . 21299907
MMP-AC0001 RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 9252 Liver Cancer HUH7 - - - - Squamocin, isolated from several genera of the plant family Annonaceae, which decreased (m)RNA expression levels of Aurora B in cancer cells and decreased the protein expression levels of aurora . 21299907