Botanical Name Plant's Common Name Plant Family   

   MMP-AC0009 : Rutin

 
Compound Name  :

Rutin
 
  Compound Class  : Flavonoid  
  Synonyms  : RUTIN; rutoside; 153-18-4; Quercetin 3-rutinoside; Bioflavonoid; Myrticolorin; Rutine; Globulariacitrin; 3-Rutinosyl quercetin; Phytomelin; 3-Rhamnoglucosylquercetin; Quercetin 3-O-rutinoside; Rutinum; Rutosido; Rutosidum; Birutan; Eldrin; Rutin trihydrate; Globularicitrin; Rutabion; Venoruton; Quercetin-3-rutinoside; Rutinic acid; Birutan Forte; Birutin; Quercetin rhamnoglucosine; Quercetin-3beta-rutinoside; UNII-5G06TVY3R7; Paliuroside; Violaquercitrin;

 
  Compound Extracted from  : Rutin is extracted / reported from 46 Plant(s) of Melghat Flora as below

MC007: Cardiospermum halicacabum L.;
MH010: Polygala arvensis Willd.;
MH028: Tribulus terrestris L.;
MH060: Pseudarthria viscida (L.)Wight & Arn.;
MH067: Vigna radiata (L.) R. Wilczek;
MH070: Cassia absus L.;
MH076: Ammannia baccifera L. ;
MH097: Oldenlandia corymbosa L.;
MH113: Dichrocephala integrifolia (L.f.) Kuntze;
MH132: Sonchus oleraceus L.;
MH159: Convolvulus arvensis L;
MH196: Blepharis maderaspatensis (L.) Heyne ex Roth.;
MH203: Hygrophila auriculata (Schumach.) Heine;
MH207: Justicia procumbens L.;
MH239: Amaranthus spinosus L.;
MH243: Digera muricata (L.) Mart.;
MH247: Polygonum glabrum Willd.;
MH248: Polygonum plebeium R. Br. ;
MH258: Euphorbia hirta L.;
MH259: Euphorbia neriifolia L.;
MH267: Pilea microphylla (L.) Liebm.;
MH337: Anagallis arvensis L.;
MH346: Aerva javanica (Burm. f.) Juss. ex Schult.;
MH383: Phyllanthus amarus Schum & Thonn.;
MH403: Rorippa indica (L.) Hiern. ;
MH413: Melilotus indica (L.) All.;
MS014: Urena lobata L.;
MS039: Indigofera tinctoria L.;
MS041: Moghania bracteata (Roxb.) H.L.Li;
MS045: Tephrosia purpurea (L.) Pers.;
MS067: Leptadenia reticulata (Retz.) Wight;
MS068: Hemidesmus indicus (L.) R. Br.;
MS091: Dendrophthoe falcata (L.f.) Ettingsh.;
MS098: Asparagus racemosus Willd.;
MS101: Solanum torvum Sw.;
MS102: Rhinacanthus communis Nees;
MS117: Capparis spinosa ;
MT008: Thespesia populnea (L.) Sol. ex Corra;
MT009: Bombax ceiba L.;
MT013: Aegle marmelos L.;
MT021: Ziziphus xylopyrus (Retz.) Willd.;
MT051: Syzygium cumini (L.) Skeels;
MT068: Cordia dichotoma Forster. f., Prodr.;
MT078: Emblica officinalis Gaertn.;
MT085: Ficus benghalensis L.;
MT115: Grevillea robusta A. Cunn. ex R. Br.;

 
 
Molecular Formula  :

C27H30O16
 
  Molecular Weight  : 610.521  
  InChi Key  :  
  IUPAC  :  
  InChi  :  
  Hydrogen Bond Donor count  : 10  
  Hydrogen Bond Acceptor count  : 16  
  Rotational Bond count  : 6  
  TPSA  : 266  
  LogP Value  :

-1.3

 
 
Lipinski Rule of Five  :

No
 
  Ghose Filter  : No  
  Veber Filter  : No  
  Muegge Filter  :

No

 
 
PubChem CID  :

5280805
 
  Drugbank ID  : DB00126  
  Super Natural  : 000153184  
  CTD  : D012431  
  HIT  : C0514  
  NCI-60 GI50 data  :

-

 
 
Reference(s)  :



 

Compound_ID Cell Lines Cancer Type IC50 Value EC50 Value ED50 Value GI50 Value References
MMP-AC0009 L929 Connective tissue - 250±9 µM - - 12628514
MMP-AC0009 L929 Connective tissue - >250 µM - - 12628514
MMP-AC0009 CCRF-HSB-2 Haematopoietic and Lymphoid tissue >40 µM - - - 10380632
MMP-AC0009 A549 Lung >40 µM - - - 10380632
MMP-AC0009 B16 melanoma 4A5 Skin >40 µM - - - 10380632
MMP-AC0009 TGBC11TKB Stomach >40 µM - - - 10380632

Compound_ID Target Gene_Name Gene_ID Cancer Cell_lines IC50 Value EC50 Value ED50 Value GI50 Value Remarks References
MMP-AC0009 CCND1 cyclin D1 595 Colon carcinogenesis - - - - - Positive Cyclin D1 expression was detected in mice on diets supplemented by rutin(P<0.005). Supplementation of rutin in a standard diet result in the expression of Cyclin D1 in normal colonic cells. 10964096
MMP-AC0009 TNF tumor necrosis factor 7124 TNF sensitive murine fibroblast cells L929 - - >250 M - The effects of flavonoid on tumor necrosis factor-R(TNF)-induced cytotoxicity in murine fibroblast L-929 cells was studied. The magnitude of protection and potentiation by this flavonoid was concentration-dependent and these effects were not altered when the flavonoid was added as much as 2 h after TNF treatment. 9287415
MMP-AC0009 TNF tumor necrosis factor 7124 TNF sensitive murine fibroblast cells L929 - - 2509 M - The effects of flavonoid on tumor necrosis factor-R(TNF)-induced cytotoxicity in murine fibroblast L-929 cells was studied. The magnitude of protection and potentiation by this flavonoid was concentration-dependent and these effects were not altered when the flavonoid was added as much as 2 h after TNF treatment. 9287415