Botanical Name Plant's Common Name Plant Family   

   MMP-AC0012 : Kaempferol

 
Compound Name  :

Kaempferol
 
  Compound Class  : Flavonoid  
  Synonyms  : kaempferol; 520-18-3; Kempferol; Kaempherol; Populnetin; Rhamnolutein; Robigenin; Trifolitin; Pelargidenolon; Rhamnolutin; Swartziol; Indigo Yellow; 3,4',5,7-Tetrahydroxyflavone Kampherol; Campherol; Kampferol; Nimbecetin; Kaemferol; 5,7,4'-Trihydroxyflavonol; 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one;

 
  Compound Extracted from  : Kaempferol is extracted / reported from 78 Plant(s) of Melghat Flora as below

MC005: Cayratia trifolia (L.) Domin.;
MC023: Argyreia nervosa (Burm. f.) Bojer;
MC037: Passiflora foetida L. - fetid passionflower;
MC038: Trichosanthes cucumerina L.;
MH008: Cleome viscosa L.;
MH010: Polygala arvensis Willd.;
MH014: Portulaca oleracea L.;
MH021: Melochia corchorifolia L.;
MH023: Corchorus fascicularis Lam.;
MH028: Tribulus terrestris L.;
MH032: Impatiens balsamina L.;
MH067: Vigna radiata (L.) R. Wilczek;
MH068: Vigna trilobata (L.)Verdc.;
MH076: Ammannia baccifera L. ;
MH085: Glinus oppositifolius (L.) Aug.DC.;
MH099: Ageratum conyzoides L. ;
MH132: Sonchus oleraceus L.;
MH159: Convolvulus arvensis L;
MH161: Evolvulus alsinoides (L.) L.;
MH168: Cuscuta chinensis Lam. ;
MH169: Cuscuta reflexa Roxb. ;
MH236: Aerva lanata (L.) Juss. ex Schult.;
MH239: Amaranthus spinosus L.;
MH247: Polygonum glabrum Willd.;
MH249: Rumex dentatus L.;
MH257: Euphorbia geniculata Ortega;
MH258: Euphorbia hirta L.;
MH262: Euphorbia thymifolia L. ;
MH266: Girardinia zeylanica Decne.;
MH269: Crotalaria verrucosa L. ;
MH337: Anagallis arvensis L.;
MH345: Sida rhombifolia Linn;
MH346: Aerva javanica (Burm. f.) Juss. ex Schult.;
MH394: Drimia indica (Roxb.) Jessop;
MH401: Hydrolea zeylanica (L.) Vahl;
MH403: Rorippa indica (L.) Hiern. ;
MH416: Rotala rotundifolia (Roxb.) Koehne;
MH422: Chenopodium album L.;
MO011: Eulophia ochreata Lindl.;
MS014: Urena lobata L.;
MS017: Waltheria americana L.;
MS069: Rotula aquatica Lour.;
MS073: Solanum incanum L.;
MS084: Nyctanthes arbor-tristis L.;
MS087: Colebrookea oppositifolia Sm.;
MS091: Dendrophthoe falcata (L.f.) Ettingsh.;
MS097: Securinega virosa (Roxb. ex Willd.) Baill.;
MS098: Asparagus racemosus Willd.;
MS101: Solanum torvum Sw.;
MT006: Flacourtia indica (Burm. f.) Merr.;
MT008: Thespesia populnea (L.) Sol. ex Corra;
MT009: Bombax ceiba L.;
MT020: Ziziphus mauritiana Lam.;
MT021: Ziziphus xylopyrus (Retz.) Willd.;
MT022: Ziziphus rugosa Lam.;
MT025: Lannea coromandelica (Houtt.) Merr.;
MT033: Ougeinia oojeinensis (Roxb.)Hochr.;
MT036: Bauhinia malabarica Roxb.;
MT038: Bauhinia racemosa Lam.;
MT039: Bauhinia variegata L.;
MT040: Cassia fistula L.;
MT042: Acacia catechu (L.f.) Willd.;
MT043: Albizia lebbeck (L.) Benth.;
MT048: Terminalia arjuna (Roxb.) Wight & Arn.;
MT052: Eugenia jambolana Lam.;
MT054: Careya arborea Roxb.;
MT078: Emblica officinalis Gaertn.;
MT090: Ficus virens W. T. Aiton ;
MT099: Sapindus laurifolius Vahl;
MT100: Acacia chundra (Rottler)Willd.;
MT105: Anacardium occidentale L.;
MT106: Azadirachta indica A. Juss. ;
MT108: Casuarina equisetifolia L. ;
MT123: Moringa oleifera Lam;
MT126: Pithecellobium dulce (Roxb.)Benth.;
MT127: Prunus persica (L.) Stokes;
MT128: Pterospermum acerifolium (L.) Willd.;
MT134: Sapium sebiferum (L.) Dum.Cours.;

 
 
Molecular Formula  :

C15H10O6
 
  Molecular Weight  : 286.239  
  InChi Key  :  
  IUPAC  :  
  InChi  :  
  Hydrogen Bond Donor count  : 4  
  Hydrogen Bond Acceptor count  : 6  
  Rotational Bond count  : 1  
  TPSA  : 107  
  LogP Value  :

1.9

 
 
Lipinski Rule of Five  :

Yes
 
  Ghose Filter  : Yes  
  Veber Filter  : Yes  
  Muegge Filter  :

Yes

 
 
PubChem CID  :

5280863
 
  Drugbank ID  : DB01852  
  Super Natural  : 000520183  
  CTD  : C006552  
  HIT  : C0453  
  NCI-60 GI50 data  :

-

 
 
Reference(s)  :

https://www.ncbi.nlm.nih.gov/pubmed/29162470


 

Compound_ID Cell Lines Cancer Type IC50 Value EC50 Value ED50 Value GI50 Value References
MMP-AC0012 26-L5 Colon 40 µg/ml - - - 11411569
MMP-AC0012 26-L5 Colon 100 µg/ml - - - 11411569
MMP-AC0012 L929 Connective tissue - 20±6 µM - - 12628514
MMP-AC0012 L929 Connective tissue - 25±7 µM - - 11411569
MMP-AC0012 CCRF-HSB-2 Haematopoietic and Lymphoid tissue >40 µM - - - 10380632
MMP-AC0012 HL-60 Haematopoietic and Lymphoid tissue 29 µM (cc-50) - - - 16158945
MMP-AC0012 HSC-2 Head and Neck 743 µM (cc-50) - - - 16158945
MMP-AC0012 A549 Lung >40 µM - - - 10380632
MMP-AC0012 HSC-3 Oral >1000 µM (cc-50) 16158945
MMP-AC0012 HSG Salivary duct >1000 µM (cc-50) - - - 16158945
MMP-AC0012 B16 melanoma 4A5 Skin >40 µM - - 10380632
MMP-AC0012 TGBC11TKB Stomach >40 µM - - - 10380632

Compound_ID Target Gene_Name Gene_ID Cancer Cell_lines IC50 Value EC50 Value ED50 Value GI50 Value Remarks References
MMP-AC0012 BAX BCL2-associated X protein 581 Gastric Cancer AGS - - - - Western blot results showed that expression level of Bax was increased in a dose-dependent manner. 22194772
MMP-AC0012 BCL2L1 BCL2-like 1 598 Gastric Cancer AGS - - - - Western blot results showed that expression level of Bcl-xL was decreased in a dose-dependent manner. 22194772
MMP-AC0012 CASP3 caspase 3, apoptosis-related cysteine peptidase 836 Gastric Cancer AGS - - - - Flavonoids caused downregulation of procaspase-3 which consequently increased the activity of caspase-3. 22194772
MMP-AC0012 CCNB1 cyclin B1 891 Gastric Cancer AGS - - - It reduces the protein level of cyclin B1 in a dose-dependent manner.Decrease of cyclin B1 expression might be a molecular mechanism through which flavonoids induce G2/M arrest. 22194772
MMP-AC0012 CDC25C cell division cycle 25 homolog C (S. pombe) 995 Gastric Cancer AGS - - - - It reduces the protein level of cdc 25c in a dose-dependent manner.Decrease of cdc 25c expression might be a molecular mechanism through which flavonoids induce G2/M arrest. 22194772
MMP-AC0012 CDK1 cyclin-dependent kinase 1 983 Gastric Cancer AGS - - - - It reduces the protein level of cdc 2 in a dose-dependent manner.Decrease of cdc 2 expression might be a molecular mechanism through which flavonoids induce G2/M arrest 22194772
MMP-AC0012 CDK1 cyclin-dependent kinase 1 983 Human Melanoma OCM-1 - - - - Kaempferol,inhibited CDK-1 by 50-70%. 11322924
MMP-AC0012 CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 1027 Human Melanoma OCM-1 - - - - The flavone apigenin which arrest cells in G2/M but were without effect on CDK2 activity, affected only marginally the level of p27KIP1 and did not induce p21CIP. 11322924
MMP-AC0012 PARP1 poly (ADP-ribose) polymerase 1 142 Gastric Cancer AGS - - - - During apoptosis, caspases induce PARP cleavage and inactivation and cleavage of PARP helps cellular disassembly and is a marker of cells undergoing apoptosis. 22194772
MMP-AC0012 RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 6197 Colon cancer HCT-116 - - - - NTD RSK2 is a critical kinase domain for substrate phosphorylation, which requires ERK-mediated activation. Kaempferol binds and suppresses theactivation of NTD RSK and that Val82 and Lys100 are critical amino acids for NTD RSK2 activity and inhibition by kaempferol resulted in decreased cell proliferation. targeting RSK2 with natural compounds, such as kaempferol, might be a good strategy for chemopreventive or chemotherapeutic application 19435896
MMP-AC0012 RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 6197 Epidermoid carcinoma A-431 - - - - NTD RSK2 is a critical kinase domain for substrate phosphorylation, which requires ERK-mediated activation. Kaempferol binds and suppresses theactivation of NTD RSK and that Val82 and Lys100 are critical amino acids for NTD RSK2 activity and inhibition by kaempferol resulted in decreased cell proliferation. targeting RSK2 with natural compounds, such as kaempferol, might be a good strategy for chemopreventive or chemotherapeutic application. 19435896
MMP-AC0012 RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 6197 Melanoma SK-MEL-28 - - - - NTD RSK2 is a critical kinase domain for substrate phosphorylation, which requires ERK-mediated activation. Kaempferol binds and suppresses theactivation of NTD RSK and that Val82 and Lys100 are critical amino acids for NTD RSK2 activity and inhibition by kaempferol resulted in decreased cell proliferation. targeting RSK2 with natural compounds, such as kaempferol, might be a good strategy for chemopreventive or chemotherapeutic application. 19435896
MMP-AC0012 RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 6197 Melanoma SK-MEL-5 - - - - NTD RSK2 is a critical kinase domain for substrate phosphorylation, which requires ERK-mediated activation. Kaempferol binds and suppresses theactivation of NTD RSK and that Val82 and Lys100 are critical amino acids for NTD RSK2 activity and inhibition by kaempferol resulted in decreased cell proliferation. targeting RSK2 with natural compounds, such as kaempferol, might be a good strategy for chemopreventive or chemotherapeutic application. 19435896
MMP-AC0012 TNF tumor necrosis factor 7124 TNF sensitive murine fibroblast cells L929 - - 206 M - The effects of flavonoid on tumor necrosis factor-R(TNF)-induced cytotoxicity in murine fibroblast L-929 cells was studied. The magnitude of protection and potentiation by this flavonoid was concentration-dependent and these effects were not altered when the flavonoid was added as much as 2 h after TNF treatment. 9287415
MMP-AC0012 TNF tumor necrosis factor 7124 TNF sensitive murine fibroblast cells L929 - - 257 M - The effects of flavonoid on tumor necrosis factor-R(TNF)-induced cytotoxicity in murine fibroblast L-929 cells was studied. The magnitude of protection and potentiation by this flavonoid was concentration-dependent and these effects were not altered when the flavonoid was added as much as 2 h after TNF treatment. 9287415