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Botanical Name Plant's Common Name Plant Family   

   MMP-AC0017 : Eriodictyol

 
Compound Name  :
Eriodictyol		  
  Compound Class  : Flavonoid  
  Synonyms  : ERIODICTYOL; 552-58-9; Eriodictiol; UNII-Q520486B8Y; CHEMBL8996; eriodicryol; eryodictiol; (S)-Eriodictyol; (+)-Eriodictyol; EINECS 209-016-4; NSC 649412; Eriodictyol with HPLC

  
  Compound Extracted from  : Eriodictyol is extracted / reported from 3 Plant(s) of Melghat Flora as below


 
 
Molecular Formula  :
C15H12O6		  
  Molecular Weight  : 288.255  
  InChi Key  :  
  IUPAC  :  
  InChi  :  
  Hydrogen Bond Donor count  : 4  
  Hydrogen Bond Acceptor count  : 6  
  Rotational Bond count  : 1  
  TPSA  : 107  
  LogP Value  :

 2

  
 
Lipinski Rule of Five  :
Yes		  
  Ghose Filter  : Yes  
  Veber Filter  : Yes  
  Muegge Filter  :

 Yes

  
 
PubChem CID  :
440735		  
  Drugbank ID  : -  
  Super Natural  : -  
  CTD  : C007619  
  HIT  : C0365  
  NCI-60 GI50 data  :

 -

  
 
Reference(s)  :
https://www.ncbi.nlm.nih.gov/pubmed/22693608

  

Compound_ID Cell Lines Cancer Type IC50 Value EC50 Value ED50 Value GI50 Value References
MMP-AC0017 MCF-7 Breast 7.26 µg/ml - - - 21835229
MMP-AC0017 CCRF-HSB-2 Haematopoietic and Lymphoid tissue 8.3 µM - - - 10380632
MMP-AC0017 A549 Lung 12.0 µM - - - 10380632
MMP-AC0017 B16 melanoma 4A5 Skin 10.0 µM - - - 10380632
MMP-AC0017 TGBC11TKB Stomach 6.2 µM - - - 10380632

Compound_ID Target Gene_Name Gene_ID Cancer Cell_lines IC50 Value EC50 Value ED50 Value GI50 Value Remarks References
MMP-AC0017 RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 6197 preneoplastic epidermal keratinocytes JB6 C141 - - - - Docking experiments using the crystal structure of the RSK2 N-terminal kinase domain combined with in vitro pulldown assays demonstrated that eriodictyol, bound with the N-terminal kinase domain of RSK2 to inhibit RSK2 N-terminal kinase activity. RSK2-ATF1 signaling plays an important role in neoplastic cell transformation and that eriodictyol is a novel natural compound for suppressing RSK2 kinase activity 21098035
MMP-AC0017 TNF tumor necrosis factor 7124 TNF sensitive murine fibroblast cells L929 - - 4±0.3 µM - The effects of flavonoid on tumor necrosis factor-R(TNF)-induced cytotoxicity in murine fibroblast L-929 cells was studied. The magnitude of protection and potentiation by this flavonoid was concentration-dependent and these effects were not altered when the flavonoid was added as much as 2 h after TNF treatment. 9287415
MMP-AC0017 TNF tumor necrosis factor 7124 TNF sensitive murine fibroblast cells L929 - - 6±1 µM - The effects of flavonoid on tumor necrosis factor-R(TNF)-induced cytotoxicity in murine fibroblast L-929 cells was studied. The magnitude of protection and potentiation by this flavonoid was concentration-dependent and these effects were not altered when the flavonoid was added as much as 2 h after TNF treatment. 9287415