Botanical Name Plant's Common Name Plant Family   

   MMP-AC0025 : Myricetin

 
Compound Name  :

Myricetin
 
  Compound Class  : Flavonoid  
  Synonyms  : myricetin; 529-44-2; Cannabiscetin; Myricetol; Myricitin; 3,3',4',5,5',7-Hexahydroxyflavone; 3,5,7,3',4',5'-Hexahydroxyflavone; UNII-76XC01FTOJ; NSC 407290; CCRIS 5838; EINECS 208-463-2; NSC407290; CHEMBL164; NSC-407290; BRN 0332331; 76XC01FTOJ;

 
  Compound Extracted from  : Myricetin is extracted / reported from 19 Plant(s) of Melghat Flora as below


 
 
Molecular Formula  :

C15H10O8
 
  Molecular Weight  : 318.237  
  InChi Key  :  
  IUPAC  :  
  InChi  :  
  Hydrogen Bond Donor count  : 6  
  Hydrogen Bond Acceptor count  : 8  
  Rotational Bond count  : 1  
  TPSA  : 148  
  LogP Value  :

1.2

 
 
Lipinski Rule of Five  :

No
 
  Ghose Filter  : Yes  
  Veber Filter  : No  
  Muegge Filter  :

No

 
 
PubChem CID  :

5281672
 
  Drugbank ID  : DB02375  
  Super Natural  : 000529442  
  CTD  : C040015  
  HIT  : C0307  
  NCI-60 GI50 data  :

529-44-2

 
 
Reference(s)  :

https://www.ncbi.nlm.nih.gov/pubmed/25349334


 

Compound_ID Cell Lines Cancer Type IC50 Value EC50 Value ED50 Value GI50 Value References
MMP-AC0025 MCF-7 Breast 2.7±0.05 µg/ml - - - 19731038
MMP-AC0025 Caco-2 Colon >50 µg/ml - - - 19731038
MMP-AC0025 ACHN Kidney 11.2±0.9 µg/ml - - - 19731038
MMP-AC0025 A549 Lung 4.6±0.09 µg/ml - - - 19731038
MMP-AC0025 COR-L23 Lung 0.5±0.004 µg/ml - - - 19731038
MMP-AC0025 LNCaP Prostate 2.1±0.04 µg/ml - - - 19731038
MMP-AC0025 A-375 Skin 3.0±0.09 µg/ml - - - 19731038
MMP-AC0025 C32 Skin 0.6±0.008 µg/ml - - - 19731038

Compound_ID Target Gene_Name Gene_ID Cancer Cell_lines IC50 Value EC50 Value ED50 Value GI50 Value Remarks References
MMP-AC0025 AKT1 v-akt murine thymoma viral oncogene homolog 1 207 Skin Carcinoma SKH-1 - - - - Myricetin-mediated inactivation of Akt in the UVB response plays a role in regulating UVB-induced carcinogenesis 21793847
MMP-AC0025 JAK1 Janus kinase 1 3716 Murine epidermal JB6 - - - - Myricetin inhibited the phosphorylation of JAK1 and their data indicate that myricetin might directly target JAK1 to block cell transformation in mouse JB6 cells. 18995957
MMP-AC0025 MAP2K4 mitogen-activated protein kinase kinase 4 6416 Skin Carcinoma SKH-1 - - - - Myricetin can bind with MKK4 directly and that it attenuated tumor necrosis factor-alpha (TNF-a)-induced JNK and ERK phosphorylation, AP-1 activation, and VEGFexpression. Myricetin fits easily into the ATP-binding site of MKK4, located between the N- and C-lobes of the kinase domain. 21793847
MMP-AC0025 RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 5894 Skin Carcinoma SKH-1 - - - - Raf kinase is a critical target for myricetin in inhibiting the UVB-induced formation of wrinkles and suppression of type I procollagen and collagen levels in mouse skin. 21793847
MMP-AC0025 STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 6774 Murine epidermal JB6 - - - - Myricetin inhibited DNA- binding and transcriptional activity of STAT3. Furthermore, myricetin inhibited the phosphorylation of STAT3 at Tyr705 and Ser72. 18995957
MMP-AC0025 TNF tumor necrosis factor 7124 TNF sensitive murine fibroblast cells L929 - - 558 M - The effects of flavonoid on tumor necrosis factor-R(TNF)-induced cytotoxicity in murine fibroblast L-929 cells was studied. The magnitude of protection and potentiation by this flavonoid was concentration-dependent and these effects were not altered when the flavonoid was added as much as 2 h after TNF treatment. 9287415
MMP-AC0025 TNF tumor necrosis factor 7124 TNF sensitive murine fibroblast cells L929 - - 596 M - The effects of flavonoid on tumor necrosis factor-R(TNF)-induced cytotoxicity in murine fibroblast L-929 cells was studied. The magnitude of protection and potentiation by this flavonoid was concentration-dependent and these effects were not altered when the flavonoid was added as much as 2 h after TNF treatment. 9287415