Vinblastine | MMP-AC0037

	Compound Name :	Vinblastine
	Compound Class :	Alkaloids
	Synonyms :	vinblastine 865-21-4 Vincaleukoblastine Vincaleucoblastine CHEBI:27375 Vinblastina (TN) Vinblastine (INN) Velban NCGC00181127-01 VLB SCHEMBL6146 CHEMBL22969 AC1L68D2 SCHEMBL17813675 MolPort-005-910-359 MolPort-039-052-379 BDBM227643 HMS2090K05 ZINC85555528 AKOS015969678 MCULE-7852064208 NCGC00181127-02 NCGC00263548-07 NCI60_004200 SC-74619 LS-187263 N2256 C07201 D08675 AB01273959-01
	Compound Extracted from :	Vinblastine is extracted / reported from 1 Plant(s) of Melghat Flora as below MH102: Blumea eriantha DC.;

	Molecular Formula :	C46H58N4O9
	Molecular Weight :	810.989
	InChi Key :	JXLYSJRDGCGARV-XQKSVPLYSA-N
	IUPAC :	-
	InChi :	InChI=1S/C46H58N4O9/c1-8-42(54)23-28-24-45(40(52)57-6,36-30(15-19-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-21-31-34(22-35(32)56-5)48(4)38-44(31)17-20-50-18-12-16-43(9-2,37(44)50)39(59-27(3)51)46(38,55)41(53)58-7/h10-14,16,21-22,28,37-39,47,54-55H,8-9,15,17-20,23-26H2,1-7H3/t28-,37+,38-,39-,42+,43-,44-,45+,46+/m1/s1
	Hydrogen Bond Donor count :	3
	Hydrogen Bond Acceptor count :	12
	Rotational Bond count :	10
	TPSA :	154
	LogP Value :	3.7

	Lipinski Rule of Five :	No
	Ghose Filter :	No
	Veber Filter :	No
	Muegge Filter :	No

	PubChem CID :	241903
	Drugbank ID :	DB00570
	Super Natural :	000865214
	CTD :	D014747
	HIT :	C0491
	NCI-60 GI50 data :	-

	Reference(s) :	https://www.ncbi.nlm.nih.gov/pubmed/22609781

Compound_ID	Cell Lines	Cancer Type	IC50 Value	EC50 Value	ED50 Value	GI50 Value	References
MMP-AC0037	26-L5	Colon	5.15 µg/ml	-	-	-	11411569
MMP-AC0037	26-L5	Colon	10 µg/ml	-	-	-	11411569
MMP-AC0037	ACHN	Kidney	22.70±0.14 µg/ml	-	-	-	17679547
MMP-AC0037	MRC5	Lung	37.00±0.44 µg/ml	-	-	-	17679547
MMP-AC0037	LNCaP	Prostate	29.32±0.86 µg/ml	-	-	-	17679547

Compound_ID	Target	Gene_Name	Gene_ID	Cancer	Cell_lines	IC50 Value	EC50 Value	ED50 Value	GI50 Value	Remarks	References
MMP-AC0037	CASP3	caspase 3, apoptosis-related cysteine peptidase	836	Cervical Carcinoma	KB-3	-	-	-	-	Results indicate a marked decrease in apoptosis and a delay in caspase-3 activation in response to vinblastine when c-Jun induction is blocked, implicating a proapoptotic role for c-Jun in this contex.	18094076
MMP-AC0037	CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	1026	Cervical Carcinoma	KB-3	-	-	-	-	Results suggest that vinblastineinduced c-Jun may down-regulate p21 only in cells that lack wild-type p53 function.	18094076
MMP-AC0037	JUN	jun proto-oncogene	3725	Cervical Carcinoma	KB-3	-	-	-	-	Vinblastine treatment in all cell lines examined causes a robust increase in c-Jun protein expression and phosphorylation and a corresponding increase in activator protein-1 (AP-1) transcriptional activity. We show in KB-3 carcinoma cells that this is due to a strong autoamplification loop involving the proximal AP-1 site in the c-Jun promoter, resulting in highly increased c-Jun mRNA and c-Jun protein.	18094076

MMP-AC0037 : Vinblastine