HOME
BROWSE
FLORA
CONTACT
Botanical Name Plant's Common Name Plant Family   

   MMP-AC0057 : Andrographolide

 
Compound Name  :
Andrographolide		  
  Compound Class  : Terpenoids  
  Synonyms  : Andrographolide; 5508-58-7; Andrographis; UNII-410105JHGR; CHEBI:65408;

  
  Compound Extracted from  : Andrographolide is extracted / reported from 1 Plant(s) of Melghat Flora as below


 
 
Molecular Formula  :
C20H30O5		  
  Molecular Weight  : 350.4  
  InChi Key  :  
  IUPAC  :  
  InChi  :  
  Hydrogen Bond Donor count  : 3  
  Hydrogen Bond Acceptor count  : 5  
  Rotational Bond count  : 3  
  TPSA  : 87  
  LogP Value  :

 2.2

  
 
Lipinski Rule of Five  :
Yes		  
  Ghose Filter  : Yes  
  Veber Filter  : Yes  
  Muegge Filter  :

 Yes

  
 
PubChem CID  :
5318517		  
  Drugbank ID  : DB05767  
  Super Natural  : -  
  CTD  : C030419  
  HIT  : C0325  
  NCI-60 GI50 data  :

 -

  
 
Reference(s)  :
https://www.ncbi.nlm.nih.gov/pubmed/29165873

  

Compound_ID Cell Lines Cancer Type IC50 Value EC50 Value ED50 Value GI50 Value References
MMP-AC0057 HL-60 Haematopoietic and Lymphoid tissue 2.42±0.61 µg/ml - - - 16395645
MMP-AC0057 H4-II-E Liver 5.98±0.75 µg/ml - - - 16395645
MMP-AC0057 CNE3 Nasopharyngeal 11.60±3.83 µg/ml - - - 16395645
MMP-AC0057 KB Nasopharyngeal 15.83±1.73 µg/ml - - - 16395645
MMP-AC0057 K-562 Haematopoietic and Lymphoid tissue 41.85 µM - - - 20974534
MMP-AC0057 THP-1 Haematopoietic and Lymphoid tissue 6.69 µM - - - 20974534
MMP-AC0057 U-937 Haematopoietic and Lymphoid tissue 12.87 µM - - - 20974534
MMP-AC0057 DU-145 Prostate - - - 7.0±1.2 µM (36h) African Journal of Pharmacy and Pharmacology Vol. 5(2). 225-233, 2011

Compound_ID Target Gene_Name Gene_ID Cancer Cell_lines IC50 Value EC50 Value ED50 Value GI50 Value Remarks References
MMP-AC0057 BAX BCL2-associated X protein 581 Hepatoma Hep G2 - - - - Bax conformational changes were proven to be caspase 8-dependent, as pretreatment with caspase 8 inhibitor (z-IETD-FMK) almost completely abolished the Andro-induced conformational changes of Bax 16740251
MMP-AC0057 BID BH3 interacting domain death agonist 637 Hepatoma Hep G2 - - - - When cells were pretreated with pan-caspase inhibitor (z-VAD-FMK) or caspase 8 inhibitor (z-IETD-FMK), the decrease of full length of Bid caused by Andro was prevented,suggesting that Bid cleavage is mediated by caspase 8 activation. 16740251
MMP-AC0057 CASP3 caspase 3, apoptosis-related cysteine peptidase 836 Hepatoma Hep G2 - - - - Around eight-fold increases of caspase 3 activity were observed after treatment with Andrographolide for 12 h. 16740251
MMP-AC0057 CASP7 caspase 7, apoptosis-related cysteine peptidase 840 Hepatoma Hep G2 - - - - Around eight-fold increases of caspase 3 activity were observed after treatment with Andrographolide for 12 h. 16740251
MMP-AC0057 CDK4 cyclin-dependent kinase 4 1019 Breast adenocarcinoma MCF-7 - - - - Andrographolide decreased the CDK4 protein levels. 14641821
MMP-AC0057 PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9 5715 Breast adenocarcinoma MCF-7 - - - - After andrographolide treatment we also observed the increased proliferation of HPBLs and the increased expression of CD3, CD4, CD8, and CD56 markers on lymphocytes 14641821