Corosolic acid | MMP-AC0069

	Compound Name :	Corosolic acid
	Compound Class :	Terpenoids
	Synonyms :	Corosolic acid; 4547-24-4; Glucosol; Colosic acid; Corsolic acid;
	Compound Extracted from :	Corosolic acid is extracted / reported from 3 Plant(s) of Melghat Flora as below MH024: Corchorus olitorius L.; MH231: Plectranthus mollis (Aiton) Spreng. ; MT055: Lagerstroemia parviflora Roxb.;

	Molecular Formula :	C30H48O4
	Molecular Weight :	472.7
	InChi Key :	HFGSQOYIOKBQOW-ZSDYHTTISA-N
	IUPAC :	(1S,2R,4aS,6aR,6aS,6bR,8aR,10R,11R,12aR,14bS)-10,11-dihydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylic acid
	InChi :	InChI=1S/C30H48O4/c1-17-10-13-30(25(33)34)15-14-28(6)19(23(30)18(17)2)8-9-22-27(5)16-20(31)24(32)26(3,4)21(27)11-12-29(22,28)7/h8,17-18,20-24,31-32H,9-16H2,1-7H3,(H,33,34)/t17-,18+,20-,21+,22-,23+,24+,27+,28-,29-,30+/m1/s1
	Hydrogen Bond Donor count :	3
	Hydrogen Bond Acceptor count :	4
	Rotational Bond count :	1
	TPSA :	77.8
	LogP Value :	6.4

	Lipinski Rule of Five :	No
	Ghose Filter :	No
	Veber Filter :	Yes
	Muegge Filter :	No

	PubChem CID :	6918774
	Drugbank ID :	-
	Super Natural :	-
	CTD :	C113861
	HIT :	-
	NCI-60 GI50 data :	-

	Reference(s) :	https://www.ncbi.nlm.nih.gov/pubmed/24566423

Compound_ID	Cell Lines	Cancer Type	IC50 Value	EC50 Value	ED50 Value	GI50 Value	References
MMP-AC0069	MCF-7	Breast	-	-	-	309±28 µM	16448187

Compound_ID	Target	Gene_Name	Gene_ID	Cancer	Cell_lines	IC50 Value	EC50 Value	ED50 Value	GI50 Value	Remarks	References
MMP-AC0069	BAX	BCL2-associated X protein	581	Cervix Adenocarcinoma	HeLa	-	-	-	-	HeLa cells resulted in an increased level of Bax expression in a time dependent manner. Results suggest that CRA-induced apoptosis in HeLa cells via alteration of the Bax/Bcl-2 ratio.	19457606
MMP-AC0069	CASP3	caspase 3, apoptosis-related cysteine peptidase	836	Cervix Adenocarcinoma	HeLa	-	-	-	-	Caspase-3 activity increased 9.6-fold after 12 h and 14.9-fold after 24 h treatment.	19457606
MMP-AC0069	CASP8	caspase 8, apoptosis-related cysteine peptidase	841	Cervix Adenocarcinoma	HeLa	-	-	-	-	The activities of caspase-8 increased 1.6-fold after 12 h, 2.3-fold after 24 h treatment, respectivel.	19457606
MMP-AC0069	CASP9	caspase 9, apoptosis-related cysteine peptidase	842	Cervix Adenocarcinoma	HeLa	-	-	-	-	The activities of caspase-9 increased 2.3-fold after 12 h,3.4-fold after 24 h treatment, respectivel.	19457606

MMP-AC0069 : Corosolic acid