Chrysoeriol | MMP-AC0085

	Compound Name :	Chrysoeriol
	Compound Class :	Flavonoid
	Synonyms :	Chrysoeriol; 491-71-4; Chryseriol; 3'-Methoxyapigenin; Luteolin 3'-methyl ether;
	Compound Extracted from :	Chrysoeriol is extracted / reported from 4 Plant(s) of Melghat Flora as below MH104: Blumea laciniata (Wall. ex Roxb.) DC. ; MH215: Rungia repens (L.) Nees; MH221: Leucas aspera (Willd.) Link; MH346: Aerva javanica (Burm. f.) Juss. ex Schult.;

	Molecular Formula :	C16H12O6
	Molecular Weight :	300.26
	InChi Key :	SCZVLDHREVKTSH-UHFFFAOYSA-N
	IUPAC :	5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)chromen-4-one
	InChi :	InChI=1S/C16H12O6/c1-21-14-4-8(2-3-10(14)18)13-7-12(20)16-11(19)5-9(17)6-15(16)22-13/h2-7,17-19H,1H3
	Hydrogen Bond Donor count :	3
	Hydrogen Bond Acceptor count :	6
	Rotational Bond count :	2
	TPSA :	96.2
	LogP Value :	1.7

	Lipinski Rule of Five :	Yes
	Ghose Filter :	Yes
	Veber Filter :	Yes
	Muegge Filter :	Yes

	PubChem CID :	5280666
	Drugbank ID :	-
	Super Natural :	-
	CTD :	C007054
	HIT :	-
	NCI-60 GI50 data :	-

	Reference(s) :	https://www.ncbi.nlm.nih.gov/pubmed/23122135

Compound_ID	Cell Lines	Cancer Type	IC50 Value	EC50 Value	ED50 Value	GI50 Value	References
MMP-AC0085	Hepa 1c1c7	Liver	36 然	-	-	-	14510590

Compound_ID	Target	Gene_Name	Gene_ID	Cancer	Cell_lines	IC50 Value	EC50 Value	ED50 Value	GI50 Value	Remarks	References
MMP-AC0085	AKT1	v-akt murine thymoma viral oncogene homolog 1	207	Multiple Myeloma	KM3	35 然ol/L	-	-	-	The level of p-AKT (s473) in KM3 cells was repressed by 48 h incubation of IC50 chrysoeriol.	21181363
MMP-AC0085	AKT1	v-akt murine thymoma viral oncogene homolog 1	207	Multiple Myeloma	RPMI-8226	35 然ol/L				The level of p-AKT (s473) in KM3 cells was repressed by 48 h incubation of IC50 chrysoeriol.	21181363
MMP-AC0085	CCNB1	cyclin B1	891	Multiple Myeloma	KM3	35 然ol/L	-	-	-	Cyclin B1 was increased in the presence of chrysoeriol in KM3 cells.	21181363
MMP-AC0085	CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	1026	Multiple Myeloma	RPMI-8226	35 然ol/L	-	-	-	An increasing tendency of p21 was observed in RPMI 8226 cells, but not in KM3 cells.	21181363

MMP-AC0085 : Chrysoeriol