Compound_ID |
Target |
Gene_Name |
Gene_ID |
Cancer |
Cell_lines |
IC50 Value |
EC50 Value |
ED50 Value |
GI50 Value |
Remarks |
References |
MMP-AC0088 |
AR |
androgen receptor |
367 |
Prostate Cancer |
LNCaP |
- |
- |
- |
- |
Result shows the significant reduction of AR expression in LNCaP cells treated with curcumin. |
12239622 |
MMP-AC0088 |
BCL2 |
B-cell CLL/lymphoma 2 |
596 |
Prostate Cancer |
DU-145 |
- |
- |
- |
- |
After treating the DU-145 cells with 50 mM curcumin, results indicate that curcumin downregulated the expression of Bcl-2. |
11753638 |
MMP-AC0088 |
BCL2 |
B-cell CLL/lymphoma 2 |
596 |
Prostate Cancer |
LNCaP |
- |
- |
- |
- |
After treating the LNCaP cells with 50 mM curcumin, results indicate that curcumin downregulated the expression of Bcl-2. |
11753638 |
MMP-AC0088 |
BCL2L1 |
BCL2-like 1 |
598 |
Prostate Cancer |
DU-145 |
- |
- |
- |
- |
After treating the DU-145 cells with 50 mM curcumin, results indicate that curcumin downregulated the expression of Bcl-xL. |
11753638 |
MMP-AC0088 |
BCL2L1 |
BCL2-like 1 |
598 |
Prostate Cancer |
LNCaP |
- |
- |
- |
- |
After treating the LNCaP cells with 50 mM curcumin, results indicate that curcumin downregulated the expression of Bcl-xL. |
11753638 |
MMP-AC0088 |
CASP3 |
caspase 3, apoptosis-related cysteine peptidase |
836 |
Prostate Cancer |
DU-145 |
- |
- |
- |
- |
100 uM curcumin activated the procaspase-3 in DU145 cells. |
11753638 |
MMP-AC0088 |
CASP3 |
caspase 3, apoptosis-related cysteine peptidase |
836 |
Prostate Cancer |
LNCaP |
- |
- |
- |
- |
100 uM curcumin activated the procaspase-3 in LNCaP cells. |
11753638 |
MMP-AC0088 |
CASP3 |
caspase 3, apoptosis-related cysteine peptidase |
836 |
Prostate Cancer |
DU-145 |
- |
- |
- |
- |
Curcumin (50 uM) was found to activate caspase-3 in DU145 cells. |
11753638 |
MMP-AC0088 |
CASP8 |
caspase 8, apoptosis-related cysteine peptidase |
841 |
Prostate Cancer |
DU-145 |
- |
- |
- |
- |
100 uM curcumin activated the procaspase-8 in DU145 cells. |
11753638 |
MMP-AC0088 |
COX-2 |
cytochrome c oxidase subunit II |
4513 |
Colon Cancer |
HT-29 |
- |
- |
- |
- |
Curcumin markedly inhibited COX-2 mRNA expression even at the 5 mM concentration after 6 h of treatment. Inhibition in COX-2 mRNA expression was also observed at higher concentrations (10-75 mM) of curcumin after 6 h of treatment. Maximum inhibition in COX-2 mRNA was observed at 75 mM curcumin. |
11566484 |
MMP-AC0088 |
DUSP10 |
dual specificity phosphatase 10 |
11221 |
Prostrate Carcinoma |
LAPC-4 |
- |
- |
- |
- |
Prostrate cancer cell line LAPC-4 retain the ability to up-regulate MKP5 in response to curcumin. |
17151092 |
MMP-AC0088 |
JUN |
jun proto-oncogene |
3725 |
Prostate Cancer |
DU-145 |
- |
- |
- |
- |
Curcumin completely suppressed AP-1 in DU145 cells at around 50 然. |
11753638 |
MMP-AC0088 |
MMP14 |
matrix metallopeptidase 14 (membrane-inserted) |
4323 |
Murine melanoma |
B16(F10) |
- |
- |
- |
- |
On treatment of B16F10 cells with curcumin (15 mM for 15 days), MT1-MMP expression was reduced virtually to background levels when compared with control B16F10 cells. MT1-MMP expression remained at background levels even after 28 days of drug withdrawa. |
15219947 |
MMP-AC0088 |
MMP2 |
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) |
4313 |
Murine melanoma |
B16(F10) |
- |
- |
- |
- |
Gelatin zymography of serum free culture medium of control (untreated) B16F10 showed presence of pro (72 kDa) and active (68 kDa)MMP-2.On treatment with curcumin(15mM),MMP-2 activity (both pro and active) was reduced after 3 - 6 days. Reduction of MMP-2 activity could be important reasons for anti-metastatic property of curcumin. |
15219947 |
MMP-AC0088 |
NFKB1 |
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
4790 |
Prostate Cancer |
LNCaP |
- |
- |
- |
- |
Curcumin completely suppressed TNF induced NF-kB activation in a dose-dependent manner, with maximum suppression occurring at around 25 然. |
11753638 |
MMP-AC0088 |
NFKBIA |
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha |
4792 |
Prostate Cancer |
LNCaP |
- |
- |
- |
- |
Phosphorylation of I-kappa-B-alpha was partially to completely inhibited by curcumin at 12.5 Amol/L after 4- and 20-hour treatment. |
15252141 |
MMP-AC0088 |
PARP1 |
poly (ADP-ribose) polymerase 1 |
142 |
Prostate Cancer |
DU-145 |
- |
- |
- |
- |
Curcumin also induced caspase-dependent cleavage of PARP in a time-dependent manner. |
11753638 |
MMP-AC0088 |
PTK2 |
PTK2 protein tyrosine kinase 2 |
5747 |
Murine melanoma |
B16(F10) |
- |
- |
- |
- |
On treatment of B16F10 cells with curcumin (15 mM for 15 days), FAK expression was reduced virtually to background levels when compared with control B16F10 cells. FAK expression remained at background levels even after 28 days of drug withdrawal. |
15219947 |