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Botanical Name Plant's Common Name Plant Family   

   MMP-AC0102 : Kaempferide

 
Compound Name  :
Kaempferide		  
  Compound Class  : Flavonoid  
  Synonyms  : Kaempferide; 491-54-3; Kaempferid; 4'-Methylkaempferol; 4'-O-Methylkaempferol;

  
  Compound Extracted from  : Kaempferide is extracted / reported from 1 Plant(s) of Melghat Flora as below


 
 
Molecular Formula  :
C16H12O6		  
  Molecular Weight  : 300.26  
  InChi Key  :  
  IUPAC  :  
  InChi  :  
  Hydrogen Bond Donor count  : 3  
  Hydrogen Bond Acceptor count  : 6  
  Rotational Bond count  : 2  
  TPSA  : 96.2  
  LogP Value  :

 2.2

  
 
Lipinski Rule of Five  :
Yes		  
  Ghose Filter  : Yes  
  Veber Filter  : Yes  
  Muegge Filter  :

 Yes

  
 
PubChem CID  :
5281666		  
  Drugbank ID  : -  
  Super Natural  : -  
  CTD  : C449720  
  HIT  : -  
  NCI-60 GI50 data  :

 -

  
 
Reference(s)  :
https://www.ncbi.nlm.nih.gov/pubmed/20104502

  

Compound_ID Cell Lines Cancer Type IC50 Value EC50 Value ED50 Value GI50 Value References
MMP-AC0102 L929 Connective tissue - 140±6 µM - - 12628514
MMP-AC0102 L929 Connective tissue - 129±10 µM - - 12628514

Compound_ID Target Gene_Name Gene_ID Cancer Cell_lines IC50 Value EC50 Value ED50 Value GI50 Value Remarks References
MMP-AC0102 TNF tumor necrosis factor 7124 TNF sensitive murine fibroblast cells L929 - - 129±10 µM - The effects of flavonoid on tumor necrosis factor-R(TNF)-induced cytotoxicity in murine fibroblast L-929 cells was studied. The magnitude of protection and potentiation by this flavonoid was concentration-dependent and these effects were not altered when the flavonoid was added as much as 2 h after TNF treatment. 9287415
MMP-AC0102 TNF tumor necrosis factor 7124 TNF sensitive murine fibroblast cells L929 - - 140±6 µM - The effects of flavonoid on tumor necrosis factor-R(TNF)-induced cytotoxicity in murine fibroblast L-929 cells was studied. The magnitude of protection and potentiation by this flavonoid was concentration-dependent and these effects were not altered when the flavonoid was added as much as 2 h after TNF treatment. 9287415