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Botanical Name Plant's Common Name Plant Family   

   MMP-AC0104 : Taxifolin

 
Compound Name  :
Taxifolin		  
  Compound Class  : Flavonoid  
  Synonyms  : TAXIFOLIN; (+)-Taxifolin; 480-18-2; dihydroquercetin; Distylin;

  
  Compound Extracted from  : Taxifolin is extracted / reported from 5 Plant(s) of Melghat Flora as below


 
 
Molecular Formula  :
C15H12O7		  
  Molecular Weight  : 304.25  
  InChi Key  :  
  IUPAC  :  
  InChi  :  
  Hydrogen Bond Donor count  : 5  
  Hydrogen Bond Acceptor count  : 7  
  Rotational Bond count  : 1  
  TPSA  : 127  
  LogP Value  :

 1.5

  
 
Lipinski Rule of Five  :
Yes		  
  Ghose Filter  : Yes  
  Veber Filter  : Yes  
  Muegge Filter  :

 Yes

  
 
PubChem CID  :
439533		  
  Drugbank ID  : DB02224  
  Super Natural  : 000480182  
  CTD  : C003377  
  HIT  : C0007  
  NCI-60 GI50 data  :

 -

  
 
Reference(s)  :
https://www.ncbi.nlm.nih.gov/pubmed/24269735

  

Compound_ID Cell Lines Cancer Type IC50 Value EC50 Value ED50 Value GI50 Value References
MMP-AC0104 L929 Connective tissue - 240±10 µM - - 12628514
MMP-AC0104 L929 Connective tissue - 200±10 µM - - 12628514
MMP-AC0104 CCRF-HSB-2 Haematopoietic and Lymphoid tissue >40 µM - - - 10380632
MMP-AC0104 A549 Lung >40 µM - - - 10380632
MMP-AC0104 B16 melanoma 4A5 Skin >40 µM - - - 10380632
MMP-AC0104 TGBC11TKB Stomach >40 µM - - - 10380632

Compound_ID Target Gene_Name Gene_ID Cancer Cell_lines IC50 Value EC50 Value ED50 Value GI50 Value Remarks References
MMP-AC0104 NQO1 NAD(P)H dehydrogenase, quinone 1 1728 Colon cancer HCT-116 - - - - Taxifolin induced a moderate increase in QR activity at a concentration range of 31.3 to 62.5 mM, while QR activity was decreased at higher concentrations (125?250 mM) due to cytotoxicity. It was cytotoxic to HCT116 cell lines, with an IC50 value of 63.42. The CD of taxifolin was 11.03 mM, leading to a CI value of 5.7. 17541156
MMP-AC0104 TNF tumor necrosis factor 7124 TNF sensitive murine fibroblast cells L929 - - 200±10 µM - The effects of flavonoid on tumor necrosis factor-R(TNF)-induced cytotoxicity in murine fibroblast L-929 cells was studied. The magnitude of protection and potentiation by this flavonoid was concentration-dependent and these effects were not altered when the flavonoid was added as much as 2 h after TNF treatment. 9287415
MMP-AC0104 TNF tumor necrosis factor 7124 TNF sensitive murine fibroblast cells L929 - - 240±10 µM - The effects of flavonoid on tumor necrosis factor-R(TNF)-induced cytotoxicity in murine fibroblast L-929 cells was studied. The magnitude of protection and potentiation by this flavonoid was concentration-dependent and these effects were not altered when the flavonoid was added as much as 2 h after TNF treatment. 9287415