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Botanical Name Plant's Common Name Plant Family   

   MMP-AC0140 : Tricin

 
Compound Name  :
Tricin		  
  Compound Class  : Flavonoid  
  Synonyms  : Tricin; 520-32-1; 5,7-dihydroxy-2-(4-hydroxy-3,5-dimethoxyphenyl)-4H-chromen-4-one; 5,7,4'-trihydroxy-3',5'-dimethoxyflavone; UNII-D51JZL38TQ;

  
  Compound Extracted from  : Tricin is extracted / reported from 3 Plant(s) of Melghat Flora as below


 
 
Molecular Formula  :
C17H14O7		  
  Molecular Weight  : 330.29  
  InChi Key  :  
  IUPAC  :  
  InChi  :  
  Hydrogen Bond Donor count  : 3  
  Hydrogen Bond Acceptor count  : 7  
  Rotational Bond count  : 3  
  TPSA  : 105  
  LogP Value  :

 1.7

  
 
Lipinski Rule of Five  :
Yes		  
  Ghose Filter  : Yes  
  Veber Filter  : Yes  
  Muegge Filter  :

 Yes

  
 
PubChem CID  :
5281702		  
  Drugbank ID  : -  
  Super Natural  : -  
  CTD  : C017769  
  HIT  : C0037  
  NCI-60 GI50 data  :

 -

  
 
Reference(s)  :
https://www.ncbi.nlm.nih.gov/pubmed/22683667

  

Compound_ID Cell Lines Cancer Type IC50 Value EC50 Value ED50 Value GI50 Value References
MMP-AC0140 MDA-MB-468 Breast 0.6±0.2 µM - - - 11097223
MMP-AC0140 SW-480 Colon 16 µM - - - 15316567
MMP-AC0140 SW-480 Colon 16.0±3.6 µM - - - 11097223

Compound_ID Target Gene_Name Gene_ID Cancer Cell_lines IC50 Value EC50 Value ED50 Value GI50 Value Remarks References
MMP-AC0140 CDC25C cell division cycle 25 homolog C (S. pombe) 995 Breast Carcinoma MDA-MB-468 - - - - Cdc 25, a protein regulator of cell-cycle transition at G2/M checkpoints as potential candidate targets with which tricin might engage in causing growth arrest. The kinase cdc 25 activate the p34cdc2-cyclin B1 complex. 15316567
MMP-AC0140 CDK1 cyclin-dependent kinase 1 983 Breast Carcinoma MDA-MB-468 - - - - p34cdc2, a protein regulator of cell-cycle transition at G2/M checkpoints as potential candidate targets with which tricin might engage in causing growth arrest. p34cdc2 is a cyclin-dependent kinase, which in association with cyclin B1 controls transition of the cell from G2 into M phase. 15316567
MMP-AC0140 CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1026 Breast Carcinoma MDA-MB-468 - - - - p21cip, a protein regulator of cell-cycle transition at G2/M checkpoints as potential candidate targets with which tricin might engage in causing growth arrest p21cip is a cyclin-dependent kinase inhibitor, which associates with the p34cdc2-cyclin B1 complex and promotes a block in both G2 and G1 phases. 15316567
MMP-AC0140 WEE1 WEE1 homolog (S. pombe) 7465 Breast Carcinoma MDA-MB-468 - - - - Wee 1, a protein regulator of cell-cycle transition at G2/M checkpoints as potential candidate targets with which tricin might engage in causing growth arrest. The kinase Wee1 inhibit the p34cdc2-cyclin B1 comple. 15316567