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Botanical Name Plant's Common Name Plant Family   

   MMP-AC0180 : Ellagic acid

 
Compound Name  :
Ellagic acid		  
  Compound Class  : Benzopyranoids  
  Synonyms  : ellagic acid; 476-66-4; Benzoaric acid; Elagostasine; Lagistase;

  
  Compound Extracted from  : Ellagic acid is extracted / reported from 25 Plant(s) of Melghat Flora as below


 
 
Molecular Formula  :
C14H6O8		  
  Molecular Weight  : 302.19  
  InChi Key  :  
  IUPAC  :  
  InChi  :  
  Hydrogen Bond Donor count  : 4  
  Hydrogen Bond Acceptor count  : 8  
  Rotational Bond count  : 0  
  TPSA  : 134  
  LogP Value  :

 1.1

  
 
Lipinski Rule of Five  :
Yes		  
  Ghose Filter  : Yes  
  Veber Filter  : Yes  
  Muegge Filter  :

 Yes

  
 
PubChem CID  :
5281855		  
  Drugbank ID  : DB08846  
  Super Natural  : 000476664  
  CTD  : D004610  
  HIT  : C0368  
  NCI-60 GI50 data  :

 476-66-4

  
 
Reference(s)  :
https://pubchem.ncbi.nlm.nih.gov/compound/5281855

  

Compound_ID Cell Lines Cancer Type IC50 Value EC50 Value ED50 Value GI50 Value References
MMP-AC0180 MCF-7 Breast >50 µg/ml - - - 19731038
MMP-AC0180 Caco-2 Colon >50 µg/ml - - - 19731038
MMP-AC0180 HL-60 Haematopoietic and Lymphoid tissue >100 µM - - - 12628514
MMP-AC0180 ACHN Kidney 38.6±2.3 µg/ml - - - 19731038
MMP-AC0180 Hepa 1c1c7 Liver 12.9 µM - - - 12628514
MMP-AC0180 A549 Lung >50 µg/ml - - - 19731038
MMP-AC0180 COR-L23 Lung 7.1±0.07 µg/ml - - - 19731038
MMP-AC0180 LNCaP Prostate >50 µg/ml - - - 19731038
MMP-AC0180 A-375 Skin 4.1±0.06 µg/ml - - - 19731038
MMP-AC0180 C32 Skin 0.8±0.07 µg/ml - - - 19731038

Compound_ID Target Gene_Name Gene_ID Cancer Cell_lines IC50 Value EC50 Value ED50 Value GI50 Value Remarks References
MMP-AC0180 CASP3 caspase 3, apoptosis-related cysteine peptidase 836 Bladder Cancer T24 - - - - The data also indicated that activation of caspase-3 contributed to ellagic acid-induced apoptosis in T24 cells. 15868936
MMP-AC0180 CDK2 Cyclin-dependent kinase 2 1017 Bladder Cancer T24 - - - - The data demonstrated that 1-50 µM ellagic acid increased p53 and p21 levels and decreased CDK2 levels. These effects of ellagic acid on p53, p21 and CDK2 were also dose-dependent. 15868936
MMP-AC0180 CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1026 Cervical Cancer CaSki - - - - Ellagic acid induce an increase in the expression of both p21 mRNA and protein. 10355751
MMP-AC0180 CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1026 Bladder Cancer T24 - - - - The data demonstrated that 1-50 µM ellagic acid increased p53 and p21 levels and decreased CDK2 levels. These effects of ellagic acid on p53, p21 and CDK2 were also dose-dependent. 15868936
MMP-AC0180 TP53 tumor protein p53 7157 Bladder Cancer T24 - - - - The data demonstrated that 1-50 µM ellagic acid increased p53 and p21 levels and decreased CDK2 levels. These effects of ellagic acid on p53, p21 and CDK2 were also dose-dependen. 15868936