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Botanical Name Plant's Common Name Plant Family   

   MMP-AC0186 : Ferulic acid

 
Compound Name  :
Ferulic acid		  
  Compound Class  : Lignans  
  Synonyms  : ferulic acid; trans-Ferulic Acid; 1135-24-6; 537-98-4; 4-Hydroxy-3-methoxycinnamic acid;

  
  Compound Extracted from  : Ferulic acid is extracted / reported from 16 Plant(s) of Melghat Flora as below


 
 
Molecular Formula  :
C10H10O4		  
  Molecular Weight  : 194.18  
  InChi Key  :  
  IUPAC  :  
  InChi  :  
  Hydrogen Bond Donor count  : 2  
  Hydrogen Bond Acceptor count  : 4  
  Rotational Bond count  : 3  
  TPSA  : 66.8  
  LogP Value  :

 1.5

  
 
Lipinski Rule of Five  :
Yes		  
  Ghose Filter  : Yes  
  Veber Filter  : Yes  
  Muegge Filter  :

 No

  
 
PubChem CID  :
445858		  
  Drugbank ID  : DB07767  
  Super Natural  : 001135246  
  CTD  : C004999  
  HIT  : -  
  NCI-60 GI50 data  :

 1135-24-6

  
 
Reference(s)  :
https://pubchem.ncbi.nlm.nih.gov/compound/445858

  

Compound_ID Cell Lines Cancer Type IC50 Value EC50 Value ED50 Value GI50 Value References
MMP-AC0186 J82 Urinary Bladder 28.8 µg/ml - - - 17587681

Compound_ID Target Gene_Name Gene_ID Cancer Cell_lines IC50 Value EC50 Value ED50 Value GI50 Value Remarks References
MMP-AC0186 GSTM1 glutathione S-transferase mu 1 2944 Colon carcinogenesis - - - - - GST activity in the liver was significantly elevated by gavage of Ferulic acid(FA) at a dose of 100 mg/kg body weight (P< 0.03). It significantly increased the activities of detoxification enzymes GST and QR in the liver and/or colonic mucosa. Thus, such evidence for the activity on the detoxifying enzymes may also be related to the blocking effect of FA on AOM-induced colon carcinogenesis. 10893437
MMP-AC0186 NQO1 NAD(P)H dehydrogenase, quinone 1 1728 Colon carcinogenesis - - - - - Ferulic acid(FA) administration at 100mg/kg dose significantly elevated QR activity in the colonic mucosa or liver (P< 0.02, P< 0<01, respectively). It significantly increased the activities of detoxification enzymes GST and QR in the liver and/or colonic mucosa. Thus, such evidence for the activity on the detoxifying enzymes may also be related to the blocking effect of FA on AOM-induced colon carcinogenesis. 10893437