Compound_ID |
Target |
Gene_Name |
Gene_ID |
Cancer |
Cell_lines |
IC50 Value |
EC50 Value |
ED50 Value |
GI50 Value |
Remarks |
References |
MMP-AC0187 |
AKT1 |
v-akt murine thymoma viral oncogene homolog 1 |
207 |
Gastric Cancer |
AGS |
- |
- |
- |
- |
The protein levels of AKT-1, decreased after AGS cell treated with gallic acid. |
20600540
|
MMP-AC0187 |
AKT1 |
v-akt murine thymoma viral oncogene homolog 1 |
207 |
Gastric Cancer |
AGS |
- |
- |
- |
- |
The protein levels of P-AKT, decreased after AGS cell treated with gallic acid. |
20600540
|
MMP-AC0187 |
CDC42 |
cell division cycle 42 (GTP binding protein, 25kDa) |
998 |
Gastric Cancer |
AGS |
- |
- |
- |
- |
After treatment of AGS cells witht different concentrations of gallic acid (2.0-3.5 µM) for 48 h, the results showed protein levels of cdc42 decreased in a dose-dependent manner. |
20600540
|
MMP-AC0187 |
IKBKE |
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon |
9641 |
Gastric Cancer |
AGS |
- |
- |
- |
- |
AGS cells were treated with or without different concentrations of gallic acid (2.0-3.5 µM) for 48 h. the protein levels of IjB increased in a dose-dependent manner. |
20600540
|
MMP-AC0187 |
MMP2 |
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) |
4313 |
Gastric Cancer |
AGS |
- |
- |
- |
- |
MMP-9 activity was markedly reduced with GA. The inhibitory effects were more significant at concentrations of 2.5 and 3.5µM.GA presents a strong suppression on AGS cell growth and MMP secretion. GA possesses almost 600 times higher suppressive effect on MMP secretion than Caffic acid and Protocatechuic acid. |
20600540
|
MMP-AC0187 |
MMP9 |
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) |
4318 |
Gastric Cancer |
AGS |
- |
- |
- |
- |
MMP-2 activity was markedly reduced with GA. The inhibitory effects were more significant at concentrations of 2.5 and 3.5µM.GA presents a strong suppression on AGS cell growth and MMP secretion. GA possesses almost 600 times higher suppressive effect on MMP secretion than Caffic acid and Protocatechuic acid. |
20600540
|
MMP-AC0187 |
NFKB1 |
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
4790 |
Gastric Cancer |
AGS |
- |
- |
- |
- |
Gallic acid inhibited the migration of AGS cells by inhibition NFKB activity and downregulation of PI3 K/AKT pathway. |
20600540
|
MMP-AC0187 |
PIK3CA |
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha |
5290 |
Gastric Cancer |
AGS |
- |
- |
- |
- |
The protein levels of PI3K, decreased after AGS cell treated with gallic acid. |
20600540
|
MMP-AC0187 |
RAC1 |
ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) |
5879 |
Gastric Cancer |
AGS |
- |
- |
- |
- |
After treatment of AGS cells witht different concentrations of gallic acid (2.0-3.5 µM) for 48 h, the results showed showed protein levels of Rac1 decreased in a dose-dependent manner. |
20600540
|
MMP-AC0187 |
RHOA |
ras homolog family member A |
387 |
Gastric Cancer |
AGS |
- |
- |
- |
- |
After treatment of AGS cells witht different concentrations of gallic acid (2.0-3.5 µM) for 48 h, the results showed showed protein levels of RhoA decreased in a dose-dependent manner. |
20600540
|
MMP-AC0187 |
RHOB |
ras homolog family member B |
388 |
Gastric Cancer |
AGS |
- |
- |
- |
- |
After treatment of AGS cells witht different concentrations of gallic acid (2.0-3.5 µM) for 48 h, the results showed showed protein levels of RhoB increased in a dose-dependent manner. |
20600540
|
MMP-AC0187 |
SULT1A3 |
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 |
6818 |
Hepatoma |
Hep G2 |
- |
- |
-- |
- |
Gallic acid was found to increase PST-P activity. Gallic acid inducing PST-P activity, in a concentration-dependent manner, in concentrations of 10-50 µM, with a maximum of 4-5-fold induction. Gallic acid, a trihydroxybenzoic acid, has been found to cause a significant increase in the activity of PST-P. PST-P mRNA expression was induced markedly by gallic acid, in a dose-responsive manner. A maximum of 4.6-fold mRNA expression was observed at 50 µM. A marked induction of PST-P mRNA expression, by gallic acid, was observed after 6 h of exposure; maximum induction of PST-P mRNA expression was observed at 12 h after the addition of 50 µM gallic acid. PST-P protein was markedly induced by gallic acid, in a dose response manner, at concentrations of 10-50 µM. A maximum of 3.5-fold induction was observed at 50 µM.Significant (p <0.05) induction of PST-P protein was observed 24 h after the addition of 50 µM gallic acid. The enhanced PST-P protein expression in HepG2 cells, after treatment with gallic acid, corresponded to the induction of PST-P activity , suggesting that the observed induction of PST-P activity, by gallic acid, is due to increased PST-P protein synthesis, through activation of gene transcription. |
15941313
|