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Botanical Name Plant's Common Name Plant Family   

   MMP-AC0189 : Gamma-Tocopherol

 
Compound Name  :
Gamma-Tocopherol		  
  Compound Class  : Terpenoids  
  Synonyms  : gamma-Tocopherol 54-28-4 D-gamma-Tocopherol (+)-gamma-Tocopherol 7,8-Dimethyltocol

  
  Compound Extracted from  : Gamma-Tocopherol is extracted / reported from 3 Plant(s) of Melghat Flora as below


 
 
Molecular Formula  :
C28H48O2		  
  Molecular Weight  : 416.7  
  InChi Key  :  
  IUPAC  :  
  InChi  :  
  Hydrogen Bond Donor count  : 1  
  Hydrogen Bond Acceptor count  : 2  
  Rotational Bond count  : 12  
  TPSA  : 29.5  
  LogP Value  :

 10.3

  
 
Lipinski Rule of Five  :
NO		  
  Ghose Filter  : NO  
  Veber Filter  : NO  
  Muegge Filter  :

 NO

  
 
PubChem CID  :
92729		  
  Drugbank ID  : DB15394  
  Super Natural  : 007616220  
  CTD  : D024504  
  HIT  : C0505  
  NCI-60 GI50 data  :

 -

  
 
Reference(s)  :
https://pubchem.ncbi.nlm.nih.gov/compound/92729#section=Computed-Properties

  

Compound_ID Cell Lines Cancer Type IC50 Value EC50 Value ED50 Value GI50 Value References
MMP-AC0189 ACHN Kidney >10.43±0.24 µg/ml - - - 17679547
MMP-AC0189 MRC5 Lung >50 µg/ml - - - 17679547
MMP-AC0189 LNCaP Prostate 11.83±0.56 µg/ml - - - 17679547

Compound_ID Target Gene_Name Gene_ID Cancer Cell_lines IC50 Value EC50 Value ED50 Value GI50 Value Remarks References
MMP-AC0189 PTGER3 prostaglandin E receptor 3 (subtype EP3) 5733 Murine monocyte/macrophage line derived from ascitic tumour induced with Abelson leukaemai virus RAW264.7 7.5±2 µM. - - - A marked increase of PGE2 generation was observed in RAW264.7 macrophage when cells were treated with 0.1 mg/ml LPS. Supplementation with gamma-Tocopherol led to a dose-dependent reduction of PGE2 synthesis. 11005841
MMP-AC0189 PTGER3 prostaglandin E receptor 3 (subtype EP3) 5733 Lung adenocarcinoma A549 4 µM. - - - A marked reducetion of PGE2 synthesis was observed in IL-1-beta-treated A549 human epithelial cells. 11005841