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Botanical Name Plant's Common Name Plant Family   

   MMP-AC0207 : Peonidin

 
Compound Name  :
Peonidin		  
  Compound Class  : Flavonoid  
  Synonyms  : peonidin cation; 3,4',5,7-tetrahydroxy-3'-methoxyflavylium

  
  Compound Extracted from  : Peonidin is extracted / reported from 2 Plant(s) of Melghat Flora as below


 
 
Molecular Formula  :
C16H13O6+		  
  Molecular Weight  : 301.27  
  InChi Key  :  
  IUPAC  :  
  InChi  :  
  Hydrogen Bond Donor count  : 4  
  Hydrogen Bond Acceptor count  : 5  
  Rotational Bond count  : 2  
  TPSA  : 91.2  
  LogP Value  :

 1.5

  
 
Lipinski Rule of Five  :
Yes		  
  Ghose Filter  : Yes  
  Veber Filter  : No  
  Muegge Filter  :

 Yes

  
 
PubChem CID  :
441773		  
  Drugbank ID  : -  
  Super Natural  : 000134010  
  CTD  : C473205  
  HIT  : -  
  NCI-60 GI50 data  :

 -

  
 
Reference(s)  :
https://pubchem.ncbi.nlm.nih.gov/compound/441773

  

Compound_ID Cell Lines Cancer Type IC50 Value EC50 Value ED50 Value GI50 Value References
MMP-AC0207 HL-60 Haematopoietic and Lymphoid tissue 9 µM - - - 18460339

Compound_ID Target Gene_Name Gene_ID Cancer Cell_lines IC50 Value EC50 Value ED50 Value GI50 Value Remarks References
MMP-AC0207 COX-1 cytochrome c oxidase subunit I 4512 Breast adenocarcinoma MCF-7 - - - - Peonidin, which have methoxyl substituents in their B ring, showed 39.6% COX-1 inhibitory activities. 12925310
MMP-AC0207 COX-1 cytochrome c oxidase subunit I 4512 Breast adenocarcinoma MCF-7 - - - - Peonidin, which have methoxyl substituents in their B ring, showed 39.6% COX-1 inhibitory activities. 12925310
MMP-AC0207 COX-1 cytochrome c oxidase subunit I 4512 CNS Cancer SF-268 - - - - Peonidin, which have methoxyl substituents in their B ring, showed 39.6% COX-1 inhibitory activities. 12925310
MMP-AC0207 COX-1 cytochrome c oxidase subunit I 4512 Colon cancer HCT-116 - - - - Peonidin, which have methoxyl substituents in their B ring, showed 39.6% COX-1 inhibitory activities. 12925310
MMP-AC0207 COX-1 cytochrome c oxidase subunit I 4512 Non-small cell lung cancer NCl-H460 - - - - Peonidin, which have methoxyl substituents in their B ring, showed 39.6% COX-1 inhibitory activities. 12925310
MMP-AC0207 COX-2 cytochrome c oxidase subunit II 4513 Breast adenocarcinoma MCF-7 - - - - Peonidin , which have methoxyl substituents in their B ring, showed 49.1% COX-2 inhibitory activities. 12925310
MMP-AC0207 COX-2 cytochrome c oxidase subunit II 4513 CNS Cancer SF-268 - - - - Peonidin , which have methoxyl substituents in their B ring, showed 49.1% COX-2 inhibitory activities. 12925310
MMP-AC0207 COX-2 cytochrome c oxidase subunit II 4513 Colon cancer HCT-116 - - - - Peonidin , which have methoxyl substituents in their B ring, showed 49.1% COX-2 inhibitory activities. 12925310
MMP-AC0207 COX-2 cytochrome c oxidase subunit II 4513 Non-small cell lung cancer NCl-H460 - - - - Peonidin , which have methoxyl substituents in their B ring, showed 49.1% COX-2 inhibitory activities. 12925310
MMP-AC0207 COX-2 cytochrome c oxidase subunit II 4513 Mouse Epidermal JB6 P+ - - - - They evaluated the ability of peonidin to inhibit TPA-induced COX-2 expression in JB6 P+ cells, and found that peonidin suppressed the expression of COX-2 in a concentration-dependent manner. 17404064
MMP-AC0207 MAPK1 mitogen-activated protein kinase 1 5594 Mouse Epidermal JB6 P+ - - - - It was found that TPA strongly induced phosphorylation of ERK-2 in JB6 P+ cells, and that this was blocked by 20 µM peonidin. 17404064
MMP-AC0207 MAPK3 mitogen-activated protein kinase 3 5595 Mouse Epidermal JB6 P+ - - - - It was found that TPA strongly induced phosphorylation of ERK-1 in JB6 P+ cells, and that this was blocked by 20 µM peonidin. 17404064