Phloroglucinol | MMP-AC0209

	Compound Name :	Phloroglucinol
	Compound Class :	Simple aromatic natural product
	Synonyms :	1,3,5-Benzenetriol; Benzene-1,3,5-triol; Phloroglucinol; Spasfon-Lyoc; Spassirex
	Compound Extracted from :	Phloroglucinol is extracted / reported from 2 Plant(s) of Melghat Flora as below MT100: Acacia chundra (Rottler)Willd.; MT112: Eucalyptus globulus Labill.;

	Molecular Formula :	C6H6O3
	Molecular Weight :	126.11
	InChi Key :	QCDYQQDYXPDABM-UHFFFAOYSA-N
	IUPAC :	benzene-1,3,5-triol
	InChi :	InChI=1S/C6H6O3/c7-4-1-5(8)3-6(9)2-4/h1-3,7-9H
	Hydrogen Bond Donor count :	0.2
	Hydrogen Bond Acceptor count :	3
	Rotational Bond count :	3
	TPSA :	0
	LogP Value :	-

	Lipinski Rule of Five :	Yes
	Ghose Filter :	No
	Veber Filter :	Yes
	Muegge Filter :	No

	PubChem CID :	359
	Drugbank ID :	DB12944
	Super Natural :	000108736
	CTD :	D010696
	HIT :	-
	NCI-60 GI50 data :	-

	Reference(s) :	https://pubchem.ncbi.nlm.nih.gov/compound/359

Compound_ID	Cell Lines	Cancer Type	IC50 Value	EC50 Value	ED50 Value	GI50 Value	References
MMP-AC0209	26-L5	Colon	-	-	20.9 然	-	11277741
MMP-AC0209	HT-1080	Connective tissue	-	-	26.4 然	-	11277741

Compound_ID	Target	Gene_Name	Gene_ID	Cancer	Cell_lines	IC50 Value	EC50 Value	ED50 Value	GI50 Value	Remarks	References
MMP-AC0209	VEGFA	vascular endothelial growth factor A	7422	Lewis Lung Carcinoma	3LLL	-	-	-	-	Phloroglucinol inhibits multiple VEGF-dependent EPC bioactivities, including the VEGF-dependent tube-forming capability and VEGF-dependent migratory capacity of EPCs in vitro. Further, this compound effectively abrogates VEGF-dependent neovessel formation in vivo, leading to delayed tumor progression and angiogenesis.	22496756

MMP-AC0209 : Phloroglucinol