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Botanical Name Plant's Common Name Plant Family   

   MMP-AC0211 : Pinocembrin

 
Compound Name  :
Pinocembrin		  
  Compound Class  : Flavonoid  
  Synonyms  : (+)-pinocoembrin; 5,7-dihydroxy-flavanone; 5,7-dihydroxyflavanone; pinocembrin; pinocembrine

  
  Compound Extracted from  : Pinocembrin is extracted / reported from 1 Plant(s) of Melghat Flora as below


 
 
Molecular Formula  :
C15H12O4		  
  Molecular Weight  : 256.25  
  InChi Key  :  
  IUPAC  :  
  InChi  :  
  Hydrogen Bond Donor count  : 2  
  Hydrogen Bond Acceptor count  : 4  
  Rotational Bond count  : 1  
  TPSA  : 66.8  
  LogP Value  :

 2.7

  
 
Lipinski Rule of Five  :
Yes		  
  Ghose Filter  : Yes  
  Veber Filter  : Yes  
  Muegge Filter  :

 Yes

  
 
PubChem CID  :
68071		  
  Drugbank ID  : -  
  Super Natural  : -  
  CTD  : C016063  
  HIT  : -  
  NCI-60 GI50 data  :

 -

  
 
Reference(s)  :
https://pubchem.ncbi.nlm.nih.gov/compound/68071

  

Compound_ID Cell Lines Cancer Type IC50 Value EC50 Value ED50 Value GI50 Value References
MMP-AC0211 NCI-H187 Lung 28.58 µg/ml - - - 19524648
MMP-AC0211 KB Nasopharyngeal 39.43 µg/ml - - - 19524648

Compound_ID Target Gene_Name Gene_ID Cancer Cell_lines IC50 Value EC50 Value ED50 Value GI50 Value Remarks References
MMP-AC0211 BAX BCL2-associated X protein 581 Colon cancer HCT-116 - - - - Pinocembrin (100 mµM) induced Bax translocation to mitochondria. Overexpression of Bax sensitized cells to pinocembrin-induced apoptosis as evidenced from MTT and chromatin condensation. 17186548
MMP-AC0211 BAX BCL2-associated X protein 581 Neuroblastoma SH-SY5Y - - - - Pinocembrin treatment reduced the expression of Bax and had no effect on Bcl-2, thus decreased the Bax-Bcl-2 ratio. 18625218
MMP-AC0211 BCL2L1 BCL2-like 1 598 Colon cancer HCT-116 - - - - Here,it is indicated that cytochrome c release induced by pinocembrin is not blocked by Bcl-XL. And overexpression of Bcl-XL only partially prevented chromatin condensation and cytochrome c release induced by pinocembrin compared to vector-transfected cells. 17186548
MMP-AC0211 CASP3 caspase 3, apoptosis-related cysteine peptidase 836 Colon cancer HCT-116 - - - - The processing of caspase-3 was evident from 24 h of pinocembrin treatment and by 48 hmore intense cleavage fragment was evident. Caspase-3 inhibitor reduced the chromatin condensation to 15%, compared to 30% in DMSO control. 17186548
MMP-AC0211 CASP9 caspase 9, apoptosis-related cysteine peptidase 842 Colon cancer HCT-116 - - - - Caspase-9 was cleaved to its cleavage fragment (37 kDa) after 48 h of pinocembrin treatment.Pinocembrin-induced caspase-9 processing is subsequent to loss of mitochondrial membrane permeabilization and release of cytochrome c into cytosol, indicating a possible role for classical mitochondrial apoptotic signaling. Caspase-9 inhibitor reduced the chromatin condensation to 18%, compared to 30% in DMSO control. 17186548
MMP-AC0211 CYCS cytochrome c 54205 Neuroblastoma SH-SY5Y - - - - Pinocembrin inhibit the release of cytochrome c from mitochondria to cytosol. 18625218
MMP-AC0211 CYCS cytochrome c 54205 Colon cancer HCT-116 - - - - The release of cytochrome c is essential for the processing of initiator caspase-9 in mitochondria-mediated apoptotic signaling. The release of cytochrome c in to cytosol began after 24 h of pinocembrin and gradually increased to 72 h. 17186548
MMP-AC0211 PARP1 poly (ADP-ribose) polymerase 1 142 Colon cancer HCT-116 - - - - PARP is an important enzyme responsible for the DNA repair and is a preferred substrate for processed caspase-7 and -3.Western blot analysis of treated samples shows that cleavage of PARP is evident only around 48 h of drug exposure. 17186548
MMP-AC0211 TP53 tumor protein p53 7157 Neuroblastoma SH-SY5Y - - - - Pinocembrin could also down-regulate the expression of p53 protein, and inhibit the release of cytochrome c from mitochondria to cytosol. 18625218