Podophyllotoxin | MMP-AC0213

	Compound Name :	Podophyllotoxin
	Compound Class :	Lignans
	Synonyms :	Condyline; Condylox; CPH86; Epipodophyllotoxin; Podocon-25; Podofilm; Podofilox;
	Compound Extracted from :	Podophyllotoxin is extracted / reported from 1 Plant(s) of Melghat Flora as below MH102: Blumea eriantha DC.;

	Molecular Formula :	C22H22O8
	Molecular Weight :	414.4
	InChi Key :	YJGVMLPVUAXIQN-XVVDYKMHSA-N
	IUPAC :	(5R,5aR,8aR,9R)-5-hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one
	InChi :	InChI=1S/C22H22O8/c1-25-16-4-10(5-17(26-2)21(16)27-3)18-11-6-14-15(30-9-29-14)7-12(11)20(23)13-8-28-22(24)19(13)18/h4-7,13,18-20,23H,8-9H2,1-3H3/t13-,18+,19-,20-/m0/s1
	Hydrogen Bond Donor count :	1
	Hydrogen Bond Acceptor count :	8
	Rotational Bond count :	4
	TPSA :	92.7
	LogP Value :	2

	Lipinski Rule of Five :	Yes
	Ghose Filter :	Yes
	Veber Filter :	Yes
	Muegge Filter :	Yes

	PubChem CID :	10607
	Drugbank ID :	DB01179
	Super Natural :	000518285
	CTD :	D011034
	HIT :	C0083
	NCI-60 GI50 data :	518-28-5

	Reference(s) :	https://pubchem.ncbi.nlm.nih.gov/compound/10607

Compound_ID	Cell Lines	Cancer Type	IC50 Value	EC50 Value	ED50 Value	GI50 Value	References
MMP-AC0213	P-388	Haematopoietic and Lymphoid tissue	4 nM	-	-	-	10477801
MMP-AC0213	RAW264.7	Haematopoietic and Lymphoid tissue	-	0.024±0.004 µM	-	-	12727276

Compound_ID	Target	Gene_Name	Gene_ID	Cancer	Cell_lines	IC50 Value	EC50 Value	ED50 Value	GI50 Value	Remarks	References
MMP-AC0213	MAPK8	mitogen-activated protein kinase 8	5599	Breast adenocarcinoma	MCF-7	-	-	-	-	Treatment of MCF-7 cells with podophyllotoxin, or vincristine also caused an increase of JNK1 activit.	9927194

MMP-AC0213 : Podophyllotoxin