Compound_ID |
Target |
Gene_Name |
Gene_ID |
Cancer |
Cell_lines |
IC50 Value |
EC50 Value |
ED50 Value |
GI50 Value |
Remarks |
References |
MMP-AC0218 |
AKT1 |
v-akt murine thymoma viral oncogene homolog 1 |
207 |
Breast adenocarcinoma |
MCF-7 |
- |
- |
- |
- |
Akt was activated (by phosphorylation) in MCF-7 cells within 1-h MøCM treatment, and Akt activities were potently inhibited by sesamin.20617373 |
20617373 |
MMP-AC0218 |
CCND1 |
cyclin D1 |
595 |
Breast adenocarcinoma |
MCF-7 |
- |
- |
- |
- |
Treatment with various concentrations of sesamin altered the expression of cyclin D1 protein. |
17640297 |
MMP-AC0218 |
CCND1 |
cyclin D1 |
595 |
Breast Carcinoma |
T-47D |
- |
- |
- |
- |
Treatment with various concentrations of sesamin altered the expression of cyclin D1 protein. |
17640297 |
MMP-AC0218 |
CCND1 |
cyclin D1 |
595 |
Lung adenocarcinom |
A549 |
- |
- |
- |
- |
Treatment with various concentrations of sesamin altered the expression of cyclin D1 protein. |
17640297 |
MMP-AC0218 |
CCND1 |
cyclin D1 |
595 |
Melanoma |
UACC-62 |
- |
- |
- |
- |
Treatment with various concentrations of sesamin altered the expression of cyclin D1 protein. |
17640297 |
MMP-AC0218 |
CCND1 |
cyclin D1 |
595 |
Osteosarcoma |
MG63 |
- |
- |
- |
- |
Treatment with various concentrations of sesamin altered the expression of cyclin D1 protein. |
17640297 |
MMP-AC0218 |
HIF1A |
hypoxia inducible factor 1 |
3091 |
Breast adenocarcinoma |
MCF-7 |
- |
- |
- |
- |
HIF-1alpha was induced in the nuclear extract of MCF-7 cells after MøCM treatment, and the induction was attenuated by sesamin. |
20617373 |
MMP-AC0218 |
IL6 |
interleukin 6 |
3569 |
Breast adenocarcinoma |
MCF-7 |
- |
- |
- |
- |
The levels of IL-6,was induced in MCF-7 cells when incubated with MfCM; additionally, sesamin was able to inhibit MfCM-induced IL-6 mRNA expression in a concentration-dependent manner. |
20617373 |
MMP-AC0218 |
IL8 |
interleukin 8 |
3576 |
Breast adenocarcinoma |
MCF-7 |
- |
- |
- |
- |
The levels of IL-8 mRNA were all induced in MCF-7 cells when incubated with MfCM; additionally, sesamin was able to inhibit MfCM-induced IL-8, expression in a concentration-dependent manner. |
20617373 |
MMP-AC0218 |
MAPK1 |
mitogen-activated protein kinase 1 |
5594 |
Breast adenocarcinoma |
MCF-7 |
- |
- |
- |
- |
p38MAPK was activated (by phosphorylation) in MCF-7 cells within 1-h MøCM treatment, and p38MAPK activities were potently inhibited by sesamin. |
20617373 |
MMP-AC0218 |
MMP9 |
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) |
4318 |
Breast Carcinoma |
MDA-MB-231 |
- |
- |
- |
- |
inhibitory effect of sesamin on macrophage-induced MMP-9 expression was also observed with MDA-MB-231 cell. |
20617373 |
MMP-AC0218 |
MMP9 |
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) |
4318 |
Breast adenocarcinoma |
MCF-7 |
- |
- |
- |
- |
MMP-9 mRNA expression was also induced in the MCF-7 cells after incubated with MfCM for 4 or 8 h, and sesamin was able to inhibit this MMP-9 mRNA induction. |
20617373 |
MMP-AC0218 |
NFKB1 |
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
4790 |
Breast adenocarcinoma |
MCF-7 |
- |
- |
- |
- |
NF-kappaB was induced in the nuclear extract of MCF-7 cells after MøCM treatment, and the induction was attenuated by sesamin. |
20617373 |
MMP-AC0218 |
PLCG1 |
phospholipase C, gamma 1 |
5335 |
Breast adenocarcinoma |
MCF-7 |
- |
- |
- |
- |
It is suggested that inhibition of PLC gamma 1 by this compound may be an important mechanism for an antiproliferative effect on the human cancer cells. |
15554262 |
MMP-AC0218 |
PLCG1 |
phospholipase C, gamma 1 |
5335 |
Colon Cancer |
HCT-15 |
- |
- |
- |
- |
It is suggested that inhibition of PLC gamma 1 by this compound may be an important mechanism for an antiproliferative effect on the human cancer cells. |
15554262 |
MMP-AC0218 |
PLCG1 |
phospholipase C, gamma 1 |
5335 |
Lung adenocarcinoma |
A549 |
- |
- |
- |
- |
It is suggested that inhibition of PLC gamma 1 by this compound may be an important mechanism for an antiproliferative effect on the human cancer cells. |
15554262 |
MMP-AC0218 |
RB1 |
retinoblastoma 1 |
5925 |
Breast adenocarcinoma |
MCF-7 |
- |
- |
- |
- |
A hyperphosphorylated form of RB protein began to be converted into a hypophosphorylated form 3 h after treatment with sesamin. |
17640297 |
MMP-AC0218 |
TNF |
tumor necrosis factor |
7124 |
Breast adenocarcinoma |
MCF-7 |
- |
- |
- |
- |
The levels of TNF-alpha mRNA were all induced in MCF-7 cells when incubated with MfCM; additionally, sesamin was able to inhibit MfCM-induced TNF-alpha mRNA expression in a concentration-dependent manner. |
20617373 |
MMP-AC0218 |
VEGFA |
vascular endothelial growth factor A |
7422 |
Breast Carcinoma |
MDA-MB-231 |
- |
- |
- |
- |
inhibitory effect of sesamin on macrophage-induced VEGF expression was also observed with MDA-MB-231 cell. |
20617373 |
MMP-AC0218 |
VEGFA |
vascular endothelial growth factor A |
7422 |
Breast adenocarcinoma |
MCF-7 |
- |
- |
- |
- |
production of VEGF was significantly enhanced when MCF-7 cells were treated 24 h with MfCM compared with control treatment (454.5±81.2 vs. 207.9±50.6 pg/ml, P<0.05). |
20617373 |