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Botanical Name Plant's Common Name Plant Family   

   MMP-AC0003 : Lupeol

 
Compound Name  :
Lupeol		  
  Compound Class  : Terpenoids  
  Synonyms  : Lupeol; Fagarasterol; Clerodol; Monogynol B; 545-47-1; farganasterol; beta-Viscol; Triterpene lupeol; Fagarsterol; Lupenol; UNII-O268W13H3O; Lup-20(29)-en-3b-ol; CHEBI:6570; .beta.-Viscol; O268W13H3O; NSC90487; MFCD00017351; AK105935; 20(29)-Lupen-3beta-ol; 20[29]-Lupen-3beta-ol; Lup-20(29)-en-3.beta.-ol; EINECS 208-889-9; NSC 90487; (3-beta)-Lup-20(29)-en-3-ol; Lup-20(29)-en-3-ol, (3beta)-; Lup-20(29)-en-3-ol, (3.beta.)-; Monogynol B (6CI); HSDB 7687; Lup-20(29)-en-3-ol, (3-beta)-; Lupeol, >=94%; Lupeol, analytical standard; AC1L61YJ; Ambap545-47-1; SCHEMBL148518; CHEMBL289191; MolPort-006-111-741; MQYXUWHLBZFQQO-QGTGJCAVSA-N; ZINC4081455; (3beta)-lup-20(29)-en-3-ol; BDBM50377927; DNC008522; NSC-90487; AKOS016008524; LMPR0106130001; Lup-20(29)-en-3beta-ol (8CI); Lup-20(29)-en-3-beta-ol (8CI); AJ-47897; BT000742; CC-30086; NCI60_042005; PL059143; AX8034045; FT-0603463; N1291; ST24047509; V0212; (3|A,13|I)-Lup-20(29)-en-3-ol; C08628; C-22186; Q-100615;

  
  Compound Extracted from  : Lupeol is extracted / reported from 58 Plant(s) of Melghat Flora as below

MC002: Ventilago denticulata Willd.;
MC014: Acacia torta (Roxb.) Craib;
MC016: Coccinia grandis (L.) Voigt;
MC022: Pergularia daemia (Forssk.) Chiov.;
MC030: Merremia turpethum (L.) Rendle;
MC058: Acacia concinna (Willd.) DC.;
MH022: Corchorus aestuans L.;
MH023: Corchorus fascicularis Lam.;
MH062: Rhynchosia minima (L.) DC.;
MH076: Ammannia baccifera L. ;
MH104: Blumea laciniata (Wall. ex Roxb.) DC. ;
MH137: Tridax procumbens (L.) L.;
MH138: Vernonia cinerea (L.) Less;
MH139: Vicoa indica (L.) DC.;
MH203: Hygrophila auriculata (Schumach.) Heine;
MH236: Aerva lanata (L.) Juss. ex Schult.;
MH241: Alternanthera sessilis (L.) R.Br. ex DC.;
MH272: Blumea lacera (Burm.f.) DC.;
MH276: Costus speciosus (J. Koenig.) Sm.;
MH349: Biophytum reinwardtii (Zucc.) Klotzsch;
MO011: Eulophia ochreata Lindl.;
MS048: Caesalpinia decapetala (Roth) Alston;
MS053: Woodfordia fruticosa (L.) Kurz;
MS066: Holostemma annulare (Roxb.) K. Schumann;
MS068: Hemidesmus indicus (L.) R. Br.;
MS079: Carvia callosa (Wall. ex Nees) Bremek.;
MS082: Clerodendrum viscosum Vent.;
MS100: Ichnocarpus ovatifolius A. DC.;
MS115: Caesalpinia pulcherrima (L.)Sw.;
MT008: Thespesia populnea (L.) Sol. ex Corrêa;
MT009: Bombax ceiba L.;
MT012: Grewia tiliifolia Vahl.;
MT013: Aegle marmelos L.;
MT018: Soymida febrifuga (Roxb.) Juss.;
MT021: Ziziphus xylopyrus (Retz.) Willd.;
MT023: Schleichera oleosa (Lour.) Oken;
MT030: Dalbergia latifolia Roxb.;
MT033: Ougeinia oojeinensis (Roxb.)Hochr.;
MT035: Pterocarpus marsupium Roxb.;
MT038: Bauhinia racemosa Lam.;
MT039: Bauhinia variegata L.;
MT040: Cassia fistula L.;
MT041: Tamarindus indica L.;
MT043: Albizia lebbeck (L.) Benth.;
MT047: Terminalia alata Heyne ex Roth;
MT063: Diospyros melanoxylon Roxb. ;
MT066: Wrightia tinctoria Roem.;
MT068: Cordia dichotoma Forster. f., Prodr.;
MT071: Oroxylum indicum (L.) Kurz;
MT078: Emblica officinalis Gaertn.;
MT080: Mallotus philippensis (Lam.) Müll. Arg.;
MT082: Trema orientalis (L.) Blume;
MT085: Ficus benghalensis L.;
MT087: Ficus hispida L. f.;
MT088: Ficus racemosa L.;
MT104: Alstonia scholaris (L.) R. Br.;
MT117: Acrocarpus fraxinifolius ;
MT137: Streblus asper Lour.;

  
 
Molecular Formula  :
C30H50O		  
  Molecular Weight  : 426.729  
  InChi Key  :  
  IUPAC  :  
  InChi  :  
  Hydrogen Bond Donor count  : 1  
  Hydrogen Bond Acceptor count  : 1  
  Rotational Bond count  : 1  
  TPSA  : 20.23  
  LogP Value  :

 5.97

  
 
Lipinski Rule of Five  :
No		  
  Ghose Filter  : No  
  Veber Filter  : Yes  
  Muegge Filter  :

 No

  
 
PubChem CID  :
259846		  
  Drugbank ID  : DB12622  
  Super Natural  : -  
  CTD  : C010480  
  HIT  : C0336  
  NCI-60 GI50 data  :

 545-47-1

  
 
Reference(s)  :


 

Compound_ID Cell Lines Cancer Type IC50 Value EC50 Value ED50 Value GI50 Value References
MMP-AC0003 MCF-7 Breast 50 µM - - - 19464787
MMP-AC0003 MDA-MB-231 Breast 28.5 µg/ml - - - 16883274
MMP-AC0003 HeLa Cervix 37 µM - - - 19464787
MMP-AC0003 HeLa Cervix 8.6 µg/ml - - - 16883274
MMP-AC0003 DLD-1 Colon 125±6 µM - - - 16787747
MMP-AC0003 CEM Haematopoietic and Lymphoid tissue 50 µM - - - 19464787
MMP-AC0003 CEM-SS Haematopoietic and Lymphoid tissue 13.8 µg/ml - - - 16883274
MMP-AC0003 RPMI-8226 Haematopoietic and Lymphoid tissue 50 µM - - - 19464787
MMP-AC0003 A549 Lung 50 µM - - - 19464787
MMP-AC0003 A549 Lung 165±8 µM - - - 16787747
MMP-AC0003 CaOV3 Ovary 28.2 µg/ml - - - 16883274
MMP-AC0003 B16-F1 Skin 104±6 µM - - - 16787747
MMP-AC0003 G361 Skin 50 µM - - - 19464787

Compound_ID Target Gene_Name Gene_ID Cancer Cell_lines IC50 Value EC50 Value ED50 Value GI50 Value Remarks References
MMP-AC0003 PROM1 prominin 1 8842 Liver Cancer HUH7 - - - - CD133 expression decreased in a time-dependent manner in Huh-7 cells upon administration of 10 lM lupeol. 20979057
MMP-AC0003 PROM1 prominin 1 8842 Liver Cancer PLC-8024 - - - - CD133 expression decreased in a time-dependent manner in PLC-8024 cells upon administration of 10 lM lupeol. 20979057