Compound_ID |
Target |
Gene_Name |
Gene_ID |
Cancer |
Cell_lines |
IC50 Value |
EC50 Value |
ED50 Value |
GI50 Value |
Remarks |
References |
MMP-AC0012 |
BAX |
BCL2-associated X protein |
581 |
Gastric Cancer |
AGS |
- |
- |
- |
- |
Western blot results showed that expression level of Bax was increased in a dose-dependent manner. |
22194772 |
MMP-AC0012 |
BCL2L1 |
BCL2-like 1 |
598 |
Gastric Cancer |
AGS |
- |
- |
- |
- |
Western blot results showed that expression level of Bcl-xL was decreased in a dose-dependent manner. |
22194772 |
MMP-AC0012 |
CASP3 |
caspase 3, apoptosis-related cysteine peptidase |
836 |
Gastric Cancer |
AGS |
- |
- |
- |
- |
Flavonoids caused downregulation of procaspase-3 which consequently increased the activity of caspase-3. |
22194772 |
MMP-AC0012 |
CCNB1 |
cyclin B1 |
891 |
Gastric Cancer |
AGS |
- |
- |
- |
|
It reduces the protein level of cyclin B1 in a dose-dependent manner.Decrease of cyclin B1 expression might be a molecular mechanism through which flavonoids induce G2/M arrest. |
22194772 |
MMP-AC0012 |
CDC25C |
cell division cycle 25 homolog C (S. pombe) |
995 |
Gastric Cancer |
AGS |
- |
- |
- |
- |
It reduces the protein level of cdc 25c in a dose-dependent manner.Decrease of cdc 25c expression might be a molecular mechanism through which flavonoids induce G2/M arrest. |
22194772 |
MMP-AC0012 |
CDK1 |
cyclin-dependent kinase 1 |
983 |
Gastric Cancer |
AGS |
- |
- |
- |
- |
It reduces the protein level of cdc 2 in a dose-dependent manner.Decrease of cdc 2 expression might be a molecular mechanism through which flavonoids induce G2/M arrest |
22194772 |
MMP-AC0012 |
CDK1 |
cyclin-dependent kinase 1 |
983 |
Human Melanoma |
OCM-1 |
- |
- |
- |
- |
Kaempferol,inhibited CDK-1 by 50-70%. |
11322924 |
MMP-AC0012 |
CDKN1B |
cyclin-dependent kinase inhibitor 1B (p27, Kip1) |
1027 |
Human Melanoma |
OCM-1 |
- |
- |
- |
- |
The flavone apigenin which arrest cells in G2/M but were without effect on CDK2 activity, affected only marginally the level of p27KIP1 and did not induce p21CIP. |
11322924 |
MMP-AC0012 |
PARP1 |
poly (ADP-ribose) polymerase 1 |
142 |
Gastric Cancer |
AGS |
- |
- |
- |
- |
During apoptosis, caspases induce PARP cleavage and inactivation and cleavage of PARP helps cellular disassembly and is a marker of cells undergoing apoptosis. |
22194772 |
MMP-AC0012 |
RPS6KA3 |
ribosomal protein S6 kinase, 90kDa, polypeptide 3 |
6197 |
Colon cancer |
HCT-116 |
- |
- |
- |
- |
NTD RSK2 is a critical kinase domain for substrate phosphorylation, which requires ERK-mediated activation. Kaempferol binds and suppresses theactivation of NTD RSK and that Val82 and Lys100 are critical amino acids for NTD RSK2 activity and inhibition by kaempferol resulted in decreased cell proliferation. targeting RSK2 with natural compounds, such as kaempferol, might be a good strategy for chemopreventive or chemotherapeutic application |
19435896 |
MMP-AC0012 |
RPS6KA3 |
ribosomal protein S6 kinase, 90kDa, polypeptide 3 |
6197 |
Epidermoid carcinoma |
A-431 |
- |
- |
- |
- |
NTD RSK2 is a critical kinase domain for substrate phosphorylation, which requires ERK-mediated activation. Kaempferol binds and suppresses theactivation of NTD RSK and that Val82 and Lys100 are critical amino acids for NTD RSK2 activity and inhibition by kaempferol resulted in decreased cell proliferation. targeting RSK2 with natural compounds, such as kaempferol, might be a good strategy for chemopreventive or chemotherapeutic application. |
19435896 |
MMP-AC0012 |
RPS6KA3 |
ribosomal protein S6 kinase, 90kDa, polypeptide 3 |
6197 |
Melanoma |
SK-MEL-28 |
- |
- |
- |
- |
NTD RSK2 is a critical kinase domain for substrate phosphorylation, which requires ERK-mediated activation. Kaempferol binds and suppresses theactivation of NTD RSK and that Val82 and Lys100 are critical amino acids for NTD RSK2 activity and inhibition by kaempferol resulted in decreased cell proliferation. targeting RSK2 with natural compounds, such as kaempferol, might be a good strategy for chemopreventive or chemotherapeutic application. |
19435896 |
MMP-AC0012 |
RPS6KA3 |
ribosomal protein S6 kinase, 90kDa, polypeptide 3 |
6197 |
Melanoma |
SK-MEL-5 |
- |
- |
- |
- |
NTD RSK2 is a critical kinase domain for substrate phosphorylation, which requires ERK-mediated activation. Kaempferol binds and suppresses theactivation of NTD RSK and that Val82 and Lys100 are critical amino acids for NTD RSK2 activity and inhibition by kaempferol resulted in decreased cell proliferation. targeting RSK2 with natural compounds, such as kaempferol, might be a good strategy for chemopreventive or chemotherapeutic application. |
19435896 |
MMP-AC0012 |
TNF |
tumor necrosis factor |
7124 |
TNF sensitive murine fibroblast cells |
L929 |
- |
- |
20±6 µM |
- |
The effects of flavonoid on tumor necrosis factor-R(TNF)-induced cytotoxicity in murine fibroblast L-929 cells was studied. The magnitude of protection and potentiation by this flavonoid was concentration-dependent and these effects were not altered when the flavonoid was added as much as 2 h after TNF treatment. |
9287415 |
MMP-AC0012 |
TNF |
tumor necrosis factor |
7124 |
TNF sensitive murine fibroblast cells |
L929 |
- |
- |
25±7 µM |
- |
The effects of flavonoid on tumor necrosis factor-R(TNF)-induced cytotoxicity in murine fibroblast L-929 cells was studied. The magnitude of protection and potentiation by this flavonoid was concentration-dependent and these effects were not altered when the flavonoid was added as much as 2 h after TNF treatment. |
9287415 |