Botanical Name Plant's Common Name Plant Family   

   MMP-AC0018 : Flavone

 
Compound Name  :

Flavone
 
  Compound Class  : Flavonoid  
  Synonyms  : FLAVONE; 525-82-6; 2-Phenylchromone; 2-Phenyl-4H-chromen-4-one; 2-Phenyl-4-chromone; 2-Phenyl-4-benzopyron; 2-Phenyl-4H-1-benzopyran-4-one; 4H-1-Benzopyran-4-one, 2-phenyl- Asmacoril; Chromocor; Cromaril; 2-Phenyl-chromen-4-one; 2-phenylchromen-4-one; Phenylchromone; 2-Phenyl-gamma-benzopyrone; 2-Phenylbenzopyran-4-one; Cromarile; 2-Phenyl-4H-benzopyran-4-one; Flavon; 2-Phenylchrome; UNII-S2V45N7G3B; NSC 19028; 2-Phenyl-4H-chromen-4-on; CCRIS 4288; NSC19028;

 
  Compound Extracted from  : Flavone is extracted / reported from 26 Plant(s) of Melghat Flora as below


 
 
Molecular Formula  :

C15H10O2
 
  Molecular Weight  : 222.243  
  InChi Key  :  
  IUPAC  :  
  InChi  :  
  Hydrogen Bond Donor count  : 0  
  Hydrogen Bond Acceptor count  : 2  
  Rotational Bond count  : 1  
  TPSA  : 26.3  
  LogP Value  :

3.6

 
 
Lipinski Rule of Five  :

Yes
 
  Ghose Filter  : Yes  
  Veber Filter  : Yes  
  Muegge Filter  :

Yes

 
 
PubChem CID  :

10680
 
  Drugbank ID  : DB07776  
  Super Natural  : -  
  CTD  : C043562  
  HIT  : C0037  
  NCI-60 GI50 data  :

-

 
 
Reference(s)  :

https://www.ncbi.nlm.nih.gov/pubmed/22292766


 

Compound_ID Cell Lines Cancer Type IC50 Value EC50 Value ED50 Value GI50 Value References
MMP-AC0018 HL-60 Haematopoietic and Lymphoid tissue >10,000 ng/ml - - - 8084211
MMP-AC0018 Molt-4 Haematopoietic and Lymphoid tissue >10,000 ng/ml - - - 8084211

Compound_ID Target Gene_Name Gene_ID Cancer Cell_lines IC50 Value EC50 Value ED50 Value GI50 Value Remarks References
MMP-AC0018 CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1026 Lung adenocarcinoma A549 - - - - Flavone induces a cyclin-dependent kinase inhibitor, p21/WAF1, without increasing the p53 protein level which results in dephosphorylation of the RB protein which is involved in the G1 phase arrest.Treatment with 100 WM ?avone induced p21/WAF1 protein 12 h after exposure, and a strong induction of p21/WAF1 protein was observed from 24 h to 48 h after exposure. 9804172
MMP-AC0018 PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9 5715 Lung adenocarcinoma A549 - - - - It was investigated the induction in A549 cells of another CDK inhibitor, p27, but only slight induction was observed upon treatment with flavone. 9804172
MMP-AC0018 RB1 retinoblastoma 1 5925 Lung adenocarcinoma A549 - - - - When A549 cells were exposed to 100 µM flavone for 12-48 h, the majority of the RB protein molecules was converted to the hypophosphorylated form. These results suggest that the G1 phase arrest caused by flavone is due to dephosphorylation of the RB protein. 9804172