Botanical Name Plant's Common Name Plant Family   

   MMP-AC0038 : Vincristine

 
Compound Name  :

Vincristine
 
  Compound Class  : Alkaloids  
  Synonyms  : cellcristin; Citomid; Farmistin; Leurocristine; Oncovin; Oncovine; Onkocristin; PFS, Vincasar; Sulfate, Vincristine; Vincasar; Vincasar PFS; Vincristin Bristol; Vincristin medac; Vincristine; Vincristine Sulfate; Vincrisul; Vintec;

 
  Compound Extracted from  : Vincristine is extracted / reported from 1 Plant(s) of Melghat Flora as below


 
 
Molecular Formula  :

C46H56N4O10
 
  Molecular Weight  : 824.972  
  InChi Key  :  
  IUPAC  :  
  InChi  :  
  Hydrogen Bond Donor count  : 3  
  Hydrogen Bond Acceptor count  : 12  
  Rotational Bond count  : 10  
  TPSA  : 171  
  LogP Value  :

2.8

 
 
Lipinski Rule of Five  :

No
 
  Ghose Filter  : No  
  Veber Filter  : No  
  Muegge Filter  :

No

 
 
PubChem CID  :

5978
 
  Drugbank ID  : DB00541  
  Super Natural  : 000057227  
  CTD  : D014750  
  HIT  : -  
  NCI-60 GI50 data  :

-

 
 
Reference(s)  :

https://www.ncbi.nlm.nih.gov/pubmed/26055805


 

Compound_ID Cell Lines Cancer Type IC50 Value EC50 Value ED50 Value GI50 Value References
MMP-AC0038 DBTRG Brain 2.1±1.0 nM - - - 16782069
MMP-AC0038 MCF-7 Breast 1.2±0.3 nM - - - 16782069
MMP-AC0038 HeLa Cervix 67.2±2.2 µg/ml - - - 11738426
MMP-AC0038 HT-29 Colon 1.1±0.5 nM - - - 16782069
MMP-AC0038 H1299 Haematopoietic and Lymphoid tissue 1.8±0.4 nM - - - 16782069
MMP-AC0038 K-562 Haematopoietic and Lymphoid tissue 3.9±0.07 µM - - - 16782069
MMP-AC0038 Hep G2 Liver 6.0±1.2 nM - - - 16782069
MMP-AC0038 SMMC-7721 Liver 30.35±2.23 µg/ml - - - 14695795
MMP-AC0038 SMMC-7721 Liver 63.2±1.8 µg/ml - - - 11738426
MMP-AC0038 A549 Liver 2.2±0.3 nM - - - 16782069
MMP-AC0038 A549-T12 Lung 2.4±0.5 nM - - - 16782069
MMP-AC0038 H520 Lung 2.7±0.2 nM - - - 16782069
MMP-AC0038 KB Nasopharyngeal 0.5±0.1 nM - - - 16782069
MMP-AC0038 KB-TAX50 Oral 2.3±0.4 nM - - - 16782069
MMP-AC0038 HO-8910 Ovary 20.74±1.91 µg/ml - - - 14695795
MMP-AC0038 OVCAR-3 Ovary 1.4±0.3 nM - - - 16782069
MMP-AC0038 B16 Skin 70.7±2.8 µg/ml - - - 11738426

Compound_ID Target Gene_Name Gene_ID Cancer Cell_lines IC50 Value EC50 Value ED50 Value GI50 Value Remarks References
MMP-AC0038 MAPK8 mitogen-activated protein kinase 8 5599 Breast adenocarcinoma MCF-7 - - - - Treatment of MCF-7 cells with podophyllotoxin, or vincristine also caused an increase of JNK1 activit. 9927194
MMP-AC0038 NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 4790 Prostate Cancer PC-3 - - - - vincristine, inhibited the NF-nB promoter activity after 18 h of treatment, and the inhibition was a function of drug concentration use. 17431117