Compound_ID |
Target |
Gene_Name |
Gene_ID |
Cancer |
Cell_lines |
IC50 Value |
EC50 Value |
ED50 Value |
GI50 Value |
Remarks |
References |
MMP-AC0041 |
COX-1 |
cytochrome c oxidase subunit I |
4512 |
Murine monocyte/macrophage line derived from ascitic tumour induced with Abelson leukaemai virus |
RAW264.7 |
5.2 µM |
- |
- |
- |
It potently inhibits cyclooxygenase 1 (Cox-1) activity and it is an anti-inflammatory mechanism. |
C. GerhäuserA.P. AltK. KlimoJ. KnauftN. FrankH. Becker, "Isolation and potential cancer chemopreventive activities of phenolic compounds of beer", Phytochemistry Reviews (2002), 1(3): 369–377 |
MMP-AC0041 |
COX-1 |
cytochrome c oxidase subunit I |
4512 |
- |
- |
1.4 µM |
- |
- |
- |
Testing of compound was performed in-vivo. Compound is shown have anticancer activity. |
11962253 |
MMP-AC0041 |
COX-2 |
cytochrome c oxidase subunit II |
4513 |
Murine monocyte/macrophage line derived from ascitic tumour induced with Abelson leukaemai virus |
RAW264.7 |
- |
- |
- |
- |
At a test concentration of 100 µM, xanthoumol inhibited Cox-2 activity 70%. |
C. GerhäuserA.P. AltK. KlimoJ. KnauftN. FrankH. Becker, "Isolation and potential cancer chemopreventive activities of phenolic compounds of beer", Phytochemistry Reviews (2002), 1(3): 369–377 |
MMP-AC0041 |
COX-2 |
cytochrome c oxidase subunit II |
4513 |
- |
- |
- |
- |
- |
- |
Testing of compound was performed in-vivo. Compound is shown have anticancer activity |
11962253 |
MMP-AC0041 |
NOS2 |
nitric oxide synthase 2, inducible |
4843 |
Murine monocyte/macrophage line derived from ascitic tumour induced with Abelson leukaemai virus |
RAW264.7 |
>50 µM |
- |
- |
- |
Nitric oxide (NO) synthase (iNOS) and consequently, enhance the generation of NO. Generally, NO is an important signaling molecule, long-term elevated levels of NO, however, have been linked to early steps in carcinogenesis.It cause inhibition of lipopolysaccharide (LPS)-mediated induction of inducible nitric oxide synthase , which is an anti-inflammatory mechanis. |
C. GerhäuserA.P. AltK. KlimoJ. KnauftN. FrankH. Becker, "Isolation and potential cancer chemopreventive activities of phenolic compounds of beer", Phytochemistry Reviews (2002), 1(3): 369–377 |
MMP-AC0041 |
NQO1 |
NAD(P)H dehydrogenase, quinone 1 |
1728 |
Murine monocyte/macrophage line derived from ascitic tumour induced with Abelson leukaemai virus |
RAW264.7 |
>50 µM |
- |
- |
- |
It induces the QR activity.Induction of phases 2 enzymes contributes to chemopreventive activity. QR is not catalyzing a conjugation reaction, but it is induced co-ordinately with other phase 2 enzymes and contributes to detoxification by reduction of reactive quinones to less reactive hydroquinones. |
C. GerhäuserA.P. AltK. KlimoJ. KnauftN. FrankH. Becker, "Isolation and potential cancer chemopreventive activities of phenolic compounds of beer", Phytochemistry Reviews (2002), 1(3): 369–377 |