Botanical Name Plant's Common Name Plant Family   

   MMP-AC0053 : Lantadene A

 
Compound Name  :

Lantadene A
 
  Compound Class  : Terpenoids  
  Synonyms  : Rehmannic acid; LANTADENE A; UNII-9SK62WCU1W; HSDB 3503; 22-beta-Angeloyloxyoleanolic acid;

 
  Compound Extracted from  : Lantadene A is extracted / reported from 1 Plant(s) of Melghat Flora as below


 
 
Molecular Formula  :

C35H52O5
 
  Molecular Weight  : 552.8  
  InChi Key  :  
  IUPAC  :  
  InChi  :  
  Hydrogen Bond Donor count  : 1  
  Hydrogen Bond Acceptor count  : 5  
  Rotational Bond count  : 4  
  TPSA  : 80.7  
  LogP Value  :

7.8

 
 
Lipinski Rule of Five  :

No
 
  Ghose Filter  : No  
  Veber Filter  : Yes  
  Muegge Filter  :

No

 
 
PubChem CID  :

6436598
 
  Drugbank ID  : -  
  Super Natural  : -  
  CTD  : C019074  
  HIT  : -  
  NCI-60 GI50 data  :

-

 
 
Reference(s)  :

https://www.ncbi.nlm.nih.gov/pubmed/18863442


 

Compound_ID Cell Lines Cancer Type IC50 Value EC50 Value ED50 Value GI50 Value References
MMP-AC0053 HL-60 Haematopoietic and Lymphoid tissue 19.8±0.10 µg/ml - - - Indian J Pharmacol.,39(3):140-144.,2007

Compound_ID Target Gene_Name Gene_ID Cancer Cell_lines IC50 Value EC50 Value ED50 Value GI50 Value Remarks References
MMP-AC0053 BAX BCL2-associated X protein 581 Human promyelocytic leukemia HL-60 - - - - Lantadene A significantly inhibited cell proliferation of HL-60 cells and induced cell apoptosis by upregulating Bax expression. Indian J Pharmacol.,39(3):140-144.,2007
MMP-AC0053 BCL2 B-cell CLL/lymphoma 2 596 Human promyelocytic leukemia HL-60 - - - - Lantadene A significantly inhibited cell proliferation of HL-60 cells and induced cell apoptosis by downregulating Bcl-2 Indian J Pharmacol.,39(3):140-144.,2007