Oleanolic Acid | MMP-AC0056

	Compound Name :	Oleanolic Acid
	Compound Class :	Terpenoids
	Synonyms :	OLEANOLIC ACID; Oleanic acid; 508-02-1; Caryophyllin; Astrantiagenin C;
	Compound Extracted from :	Oleanolic Acid is extracted / reported from 38 Plant(s) of Melghat Flora as below MC015: Combretum ovalifolium Roxb.; MH023: Corchorus fascicularis Lam.; MH024: Corchorus olitorius L.; MH071: Cassia mimosoides DC.; MH084: Glinus lotoides L.; MH085: Glinus oppositifolius (L.) Aug.DC.; MH086: Mollugo pentaphylla L.; MH097: Oldenlandia corymbosa L.; MH137: Tridax procumbens (L.) L.; MH221: Leucas aspera (Willd.) Link; MH223: Leucas cephalotes (Roth) Spreng.; MH235: Achyranthes aspera L.; MH239: Amaranthus spinosus L.; MH248: Polygonum plebeium R. Br. ; MH285: Rubia cordifolia L. ; MH286: Salvia plebeia R.Br.; MH422: Chenopodium album L.; MS053: Woodfordia fruticosa (L.) Kurz; MS054: Ludwigia octovalvis (Jacq.) P.H. Raven; MS081: Clerodendrum serratum (L.) Moon; MS091: Dendrophthoe falcata (L.f.) Ettingsh.; MS092: Viscum articulatum Burm. f.; MS100: Ichnocarpus ovatifolius A. DC.; MT020: Ziziphus mauritiana Lam.; MT021: Ziziphus xylopyrus (Retz.) Willd.; MT022: Ziziphus rugosa Lam.; MT028: Spondias pinnata (L. f.) Kurz; MT030: Dalbergia latifolia Roxb.; MT045: Albizia procera (Roxb.) Benth.; MT051: Syzygium cumini (L.) Skeels; MT057: Gardenia latifolia Aiton; MT058: Gardenia turgida Roxb.; MT061: Xeromphis uliginosa (Retz.) Maheshw; MT063: Diospyros melanoxylon Roxb. ; MT072: Radermachera xylocarpa (Roxb.) Roxb. ex K.Schum.; MT078: Emblica officinalis Gaertn.; MT087: Ficus hispida L. f.; MT099: Sapindus laurifolius Vahl;

	Molecular Formula :	C30H48O3
	Molecular Weight :	456.7
	InChi Key :	MIJYXULNPSFWEK-GTOFXWBISA-N
	IUPAC :	(4aS,6aR,6aS,6bR,8aR,10S,12aR,14bS)-10-hydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid
	InChi :	InChI=1S/C30H48O3/c1-25(2)14-16-30(24(32)33)17-15-28(6)19(20(30)18-25)8-9-22-27(5)12-11-23(31)26(3,4)21(27)10-13-29(22,28)7/h8,20-23,31H,9-18H2,1-7H3,(H,32,33)/t20-,21-,22+,23-,27-,28+,29+,30-/m0/s1
	Hydrogen Bond Donor count :	2
	Hydrogen Bond Acceptor count :	3
	Rotational Bond count :	1
	TPSA :	57.5
	LogP Value :	7.5

	Lipinski Rule of Five :	No
	Ghose Filter :	No
	Veber Filter :	Yes
	Muegge Filter :	No

	PubChem CID :	10494
	Drugbank ID :	-
	Super Natural :	000508021
	CTD :	D009828
	HIT :	C0577
	NCI-60 GI50 data :	-

	Reference(s) :	https://www.ncbi.nlm.nih.gov/pubmed/25111957

Compound_ID	Cell Lines	Cancer Type	IC50 Value	EC50 Value	ED50 Value	GI50 Value	References
MMP-AC0056	MCF-7	Breast	-	-	-	263±25 µM	16448187
MMP-AC0056	LOX-IMVI	Colon	-	-	>20 µM	-	14735446
MMP-AC0056	K-562	Haematopoietic and Lymphoid tissue	-	-	>20 µM	-	14735446
MMP-AC0056	A549	Lung	-	-	>20 µM	-	14735446
MMP-AC0056	PC-3	Prostate	-	-	1.5±2.1 µM	-	14735446
MMP-AC0056	B16(F10)	Skin	-	-	>20 µM	-	14735446

Compound_ID	Target	Gene_Name	Gene_ID	Cancer	Cell_lines	IC50 Value	EC50 Value	ED50 Value	GI50 Value	Remarks	References
MMP-AC0056	CASP3	caspase 3, apoptosis-related cysteine peptidase	836	Hepatocellular carcinoma	HA22T	-	-	-	-	Oleanolic acid treatments concentration-dependently elevated caspase-3 activities.	20005942
MMP-AC0056	CASP3	caspase 3, apoptosis-related cysteine peptidase	836	Hepatoma	Hep-3B	-	-	-	-	Oleanolic acid treatments concentration-dependently elevated caspase-3 activities.	20005942
MMP-AC0056	CASP8	caspase 8, apoptosis-related cysteine peptidase	841	Hepatocellular carcinoma	HA22T	-	-	-	-	Oleanolic acid treatments concentration-dependently elevated caspase-8 activities.	20005942
MMP-AC0056	CASP8	caspase 8, apoptosis-related cysteine peptidase	841	Hepatoma	Hep-3B	-	-	-	-	Oleanolic acid treatments concentration-dependently elevated caspase-8 activities.	20005942
MMP-AC0056	ICAM1	intercellular adhesion molecule 1	3383	Hepatocellular carcinoma	HA22T	-	-	-	-	Compound concentration-dependently inhibited cell adhesion and decreased ICAM-1 level.	20005942
MMP-AC0056	ICAM1	intercellular adhesion molecule 1	3383	Hepatoma	Hep-3B	-	-	-	-	Compound concentration-dependently inhibited cell adhesion and decreased ICAM-1 level.	20005942

MMP-AC0056 : Oleanolic Acid