Compound_ID |
Target |
Gene_Name |
Gene_ID |
Cancer |
Cell_lines |
IC50 Value |
EC50 Value |
ED50 Value |
GI50 Value |
Remarks |
References |
MMP-AC0070 |
AKT1 |
v-akt murine thymoma viral oncogene homolog 1 |
207 |
Human promyelocytic leukemia |
HL-60 |
- |
- |
- |
- |
P-Akt protein level in HL-60 cells was reduced after 24-48 h treatment with deguelin at the concentrations of 20.14 nM. This indicates that deguelin promotes P-Akt protein degradation in HL-60 cells in a time-dependent manner. |
19455392 |
MMP-AC0070 |
BCL2 |
B-cell CLL/lymphoma 2 |
596 |
Human promyelocytic leukemia |
HL-60 |
- |
- |
- |
- |
After treated with 20.14 µM deguelin for 24, 48 h, the expression of Bcl-2 was down-regulated dramatically in a time-dependent manner. |
19455392 |
MMP-AC0070 |
birc5a |
baculoviral IAP repeat-containing 5a |
373110 |
Adult T-cell leukemia (ATL) |
KUT-1 |
- |
- |
- |
- |
Deguelin treatment for 24 h reduced the protein level of survivin. These results suggest that cell death of KUT-1 cells by deguelin is induced in part via the down-regulation of survivin expression. |
19781773 |
MMP-AC0070 |
CASP3 |
caspase 3, apoptosis-related cysteine peptidase |
836 |
Adult T-cell leukemia (ATL) |
KUT-1 |
- |
- |
- |
- |
Caspase-3 was cleaved after treatment of KUT-1 cells with deguelin for at least 24 h, suggesting that deguelin induces cell death of these cells, at least in part via the apoptosis pathway involving caspase-3. |
19781773 |
MMP-AC0070 |
HSPA4 |
heat shock 70kDa protein 4 |
3308 |
Adult T-cell leukemia (ATL) |
KUT-1 |
- |
- |
- |
- |
Deguelin upregulated Hsp70 expression as well as 17-DMAG(Hsp90 inhibitor). These results suggested that deguelin acts as Hsp90 inhibitor in KUT-1 cells. |
19781773 |
MMP-AC0070 |
PARP1 |
poly (ADP-ribose) polymerase 1 |
142 |
Adult T-cell leukemia (ATL) |
KUT-1 |
- |
- |
- |
- |
PARP was cleaved after treatment of KUT-1 cells with deguelin for at least 24 h, suggesting that deguelin induces cell death of these cells. |
19781773 |
MMP-AC0070 |
STAT3 |
signal transducer and activator of transcription 3 (acute-phase response factor) |
6774 |
Adult T-cell leukemia (ATL) |
KUT-1 |
- |
- |
- |
- |
STAT3 phosphorylationwas suppressed at 6-9 h, after treatment of KUT-1 andMT-2 cellswith deguelin. On the other hand, Erk1/2 phosphorylation was not inhibited by deguelin treatment in these cells , indicating the selectivity of deguelin for STAT proteins in KUT-1 and MT-2 cells. |
19781773 |
MMP-AC0070 |
STAT5B |
signal transducer and activator of transcription 5B |
6777 |
Adult T-cell leukemia (ATL) |
KUT-1 |
- |
- |
- |
- |
STAT5 phosphorylation was suppressed in KUT-1 but not MT-2 cells. On the other hand, Erk1/2 phosphorylation was not inhibited by deguelin treatment in these cells , indicating the selectivity of deguelin for STAT proteins in KUT-1 and MT-2 cells. |
19781773 |