Botanical Name Plant's Common Name Plant Family   

   MMP-AC0088 : Curcumin

 
Compound Name  :

Curcumin
 
  Compound Class  : Flavonoid  
  Synonyms  : curcumin; 458-37-7; Diferuloylmethane; Natural yellow 3; Turmeric yellow;

 
  Compound Extracted from  : Curcumin is extracted / reported from 1 Plant(s) of Melghat Flora as below


 
 
Molecular Formula  :

C21H20O6
 
  Molecular Weight  : 368.4  
  InChi Key  :  
  IUPAC  :  
  InChi  :  
  Hydrogen Bond Donor count  : 2  
  Hydrogen Bond Acceptor count  : 6  
  Rotational Bond count  : 8  
  TPSA  : 93.1  
  LogP Value  :

3.2

 
 
Lipinski Rule of Five  :

Yes
 
  Ghose Filter  : Yes  
  Veber Filter  : Yes  
  Muegge Filter  :

Yes

 
 
PubChem CID  :

969516
 
  Drugbank ID  : DB11672  
  Super Natural  : 000458377  
  CTD  : D003474  
  HIT  : C0431  
  NCI-60 GI50 data  :

458-37-7

 
 
Reference(s)  :

https://www.ncbi.nlm.nih.gov/pubmed/29723631


 

Compound_ID Cell Lines Cancer Type IC50 Value EC50 Value ED50 Value GI50 Value References
MMP-AC0088 Colon 26-L5 Colon - - 23.2 然 - 11379774
MMP-AC0088 HT-1080 Connective tissue - - 23.4 然 - 11379774
MMP-AC0088 HL-60 Haematopoietic and Lymphoid tissue 12.5 然 - - - 12628514
MMP-AC0088 Hepa 1c1c7 Liver 9.7 然 - - - 12628514
MMP-AC0088 Hep G2 Liver 85.98 然ol/L - - - 18395899

Compound_ID Target Gene_Name Gene_ID Cancer Cell_lines IC50 Value EC50 Value ED50 Value GI50 Value Remarks References
MMP-AC0088 AR androgen receptor 367 Prostate Cancer LNCaP - - - - Result shows the significant reduction of AR expression in LNCaP cells treated with curcumin. 12239622
MMP-AC0088 BCL2 B-cell CLL/lymphoma 2 596 Prostate Cancer DU-145 - - - - After treating the DU-145 cells with 50 mM curcumin, results indicate that curcumin downregulated the expression of Bcl-2. 11753638
MMP-AC0088 BCL2 B-cell CLL/lymphoma 2 596 Prostate Cancer LNCaP - - - - After treating the LNCaP cells with 50 mM curcumin, results indicate that curcumin downregulated the expression of Bcl-2. 11753638
MMP-AC0088 BCL2L1 BCL2-like 1 598 Prostate Cancer DU-145 - - - - After treating the DU-145 cells with 50 mM curcumin, results indicate that curcumin downregulated the expression of Bcl-xL. 11753638
MMP-AC0088 BCL2L1 BCL2-like 1 598 Prostate Cancer LNCaP - - - - After treating the LNCaP cells with 50 mM curcumin, results indicate that curcumin downregulated the expression of Bcl-xL. 11753638
MMP-AC0088 CASP3 caspase 3, apoptosis-related cysteine peptidase 836 Prostate Cancer DU-145 - - - - 100 uM curcumin activated the procaspase-3 in DU145 cells. 11753638
MMP-AC0088 CASP3 caspase 3, apoptosis-related cysteine peptidase 836 Prostate Cancer LNCaP - - - - 100 uM curcumin activated the procaspase-3 in LNCaP cells. 11753638
MMP-AC0088 CASP3 caspase 3, apoptosis-related cysteine peptidase 836 Prostate Cancer DU-145 - - - - Curcumin (50 uM) was found to activate caspase-3 in DU145 cells. 11753638
MMP-AC0088 CASP8 caspase 8, apoptosis-related cysteine peptidase 841 Prostate Cancer DU-145 - - - - 100 uM curcumin activated the procaspase-8 in DU145 cells. 11753638
MMP-AC0088 COX-2 cytochrome c oxidase subunit II 4513 Colon Cancer HT-29 - - - - Curcumin markedly inhibited COX-2 mRNA expression even at the 5 mM concentration after 6 h of treatment. Inhibition in COX-2 mRNA expression was also observed at higher concentrations (10-75 mM) of curcumin after 6 h of treatment. Maximum inhibition in COX-2 mRNA was observed at 75 mM curcumin. 11566484
MMP-AC0088 DUSP10 dual specificity phosphatase 10 11221 Prostrate Carcinoma LAPC-4 - - - - Prostrate cancer cell line LAPC-4 retain the ability to up-regulate MKP5 in response to curcumin. 17151092
MMP-AC0088 JUN jun proto-oncogene 3725 Prostate Cancer DU-145 - - - - Curcumin completely suppressed AP-1 in DU145 cells at around 50 然. 11753638
MMP-AC0088 MMP14 matrix metallopeptidase 14 (membrane-inserted) 4323 Murine melanoma B16(F10) - - - - On treatment of B16F10 cells with curcumin (15 mM for 15 days), MT1-MMP expression was reduced virtually to background levels when compared with control B16F10 cells. MT1-MMP expression remained at background levels even after 28 days of drug withdrawa. 15219947
MMP-AC0088 MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 4313 Murine melanoma B16(F10) - - - - Gelatin zymography of serum free culture medium of control (untreated) B16F10 showed presence of pro (72 kDa) and active (68 kDa)MMP-2.On treatment with curcumin(15mM),MMP-2 activity (both pro and active) was reduced after 3 - 6 days. Reduction of MMP-2 activity could be important reasons for anti-metastatic property of curcumin. 15219947
MMP-AC0088 NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 4790 Prostate Cancer LNCaP - - - - Curcumin completely suppressed TNF induced NF-kB activation in a dose-dependent manner, with maximum suppression occurring at around 25 然. 11753638
MMP-AC0088 NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 4792 Prostate Cancer LNCaP - - - - Phosphorylation of I-kappa-B-alpha was partially to completely inhibited by curcumin at 12.5 Amol/L after 4- and 20-hour treatment. 15252141
MMP-AC0088 PARP1 poly (ADP-ribose) polymerase 1 142 Prostate Cancer DU-145 - - - - Curcumin also induced caspase-dependent cleavage of PARP in a time-dependent manner. 11753638
MMP-AC0088 PTK2 PTK2 protein tyrosine kinase 2 5747 Murine melanoma B16(F10) - - - - On treatment of B16F10 cells with curcumin (15 mM for 15 days), FAK expression was reduced virtually to background levels when compared with control B16F10 cells. FAK expression remained at background levels even after 28 days of drug withdrawal. 15219947