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Botanical Name Plant's Common Name Plant Family   

   MMP-AC0095 : Acacetin

 
Compound Name  :
Acacetin		  
  Compound Class  : Flavonoid  
  Synonyms  : acacetin; 480-44-4; Linarigenin; 5,7-Dihydroxy-4'-methoxyflavone; 4'-Methoxyapigenin;

  
  Compound Extracted from  : Acacetin is extracted / reported from 2 Plant(s) of Melghat Flora as below


 
 
Molecular Formula  :
C16H12O5		  
  Molecular Weight  : 284.26  
  InChi Key  :  
  IUPAC  :  
  InChi  :  
  Hydrogen Bond Donor count  : 2  
  Hydrogen Bond Acceptor count  : 5  
  Rotational Bond count  : 2  
  TPSA  : 76  
  LogP Value  :

 2.1

  
 
Lipinski Rule of Five  :
Yes		  
  Ghose Filter  : Yes  
  Veber Filter  : Yes  
  Muegge Filter  :

 Yes

  
 
PubChem CID  :
5280442		  
  Drugbank ID  : -  
  Super Natural  : -  
  CTD  : C023717  
  HIT  : C0348  
  NCI-60 GI50 data  :

 -

  
 
Reference(s)  :
https://www.ncbi.nlm.nih.gov/pubmed/25455453

  

Compound_ID Cell Lines Cancer Type IC50 Value EC50 Value ED50 Value GI50 Value References
MMP-AC0095 CCRF-HSB-2 Haematopoietic and Lymphoid tissue >40 然 - - - 10380632
MMP-AC0095 A549 Lung 9.46 mM - - - 15246561
MMP-AC0095 A549 Lung >40 然 - - - 10380632
MMP-AC0095 B16 melanoma 4A5 Skin >40 然 - - - 10380632
MMP-AC0095 TGBC11TKB Stomach >40 然 - - - 10380632

Compound_ID Target Gene_Name Gene_ID Cancer Cell_lines IC50 Value EC50 Value ED50 Value GI50 Value Remarks References
MMP-AC0095 AKT1 v-akt murine thymoma viral oncogene homolog 1 207 Ovarian adenocarcinoma OVCAR-3 - - - - The potential mechanism of acacetin in inhibiting VEGF expression, they showed that acacetin inhibited AKT activation. 21893035
MMP-AC0095 AKT1 v-akt murine thymoma viral oncogene homolog 1 207 Ovarian Cancer A-2780 - - - - The potential mechanism of acacetin in inhibiting VEGF expression, they showed that acacetin inhibited AKT activation. 21893035
MMP-AC0095 CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1026 Lung adenocarcinoma A549 - - - - Increase in p21/WAF1 protein was apparent at 6 h and reached maximuminduction at 24 h in acacetin treated A549 cells. Moreover, the induction of p21/WAF1 was observed to be in a dose-dependent manner. Based on these data, we suggest that acacetin-mediated cell cycle arrest might operate through the induction of p21/WAF1 protein on a p53-dependent event in A549 cells. 15246561
MMP-AC0095 HIF1A hypoxia inducible factor 1 3091 Ovarian adenocarcinoma OVCAR-3 - - - - Acacetin inhibited HIF-1alpha expression by increased HIF-1alpha protein degradation.The half-life of HIF-1alpha was 4.2 min and 5.2 min in OVCAR-3 and A2780 cells, respectively, in the presence of CHX alone, and was decreased to 2 min and 1.4 min, respectively with the treatment of acacetin. 21893035
MMP-AC0095 HIF1A hypoxia inducible factor 1 3091 Ovarian Cancer A-2780 - - - - Acacetin inhibited HIF-1alphalpha expression by increased HIF-1alpha protein degradation.The half-life of HIF-1alphalpha was 4.2 min and 5.2 min in OVCAR-3 and A2780 cells, respectively, in the presence of CHX alone, and was decreased to 2 min and 1.4 min, respectively with the treatment of acacetin. 21893035
MMP-AC0095 HIF1A hypoxia inducible factor 1 3091 Ovarian carcinoma OVCAR-3 - - - - The micro-vessel density was decreased by acacetin treatment to 50% of the control,showing that acacetin inhibited ovarian cancer cells-induced angiogenesis in vivo. Acacetin inhibited the levels of HIF-1alpha in tumor tissue samples 21893035
MMP-AC0095 TP53 tumor protein p53 7157 Lung adenocarcinoma A549 - - - - The results showed a marked induction of p53 protein in the acacetin treated cells and a trend of dose-dependent manner. The upregulation of p53 by acacetin started to increase 6 h after being treated with acacetin, and maximum expression was observed at 12 h. 15246561
MMP-AC0095 VEGFA vascular endothelial growth factor A 7422 Ovarian adenocarcinoma OVCAR-3 - - - - Acacetin decreased VEGF transcriptional activation to 40% in OVCAR-3 cells, suggesting that this compound has a general effect to inhibit VEGF transcriptional activation in ovarian cancer cells. Acacetin at 10 然 and 20 然 greatly inhibited VEGF expression in OVCAR-3 cells. 21893035
MMP-AC0095 VEGFA vascular endothelial growth factor A 7422 Ovarian Cancer A-2780 - - - - Acacetin decreased VEGF transcriptional activation to 50% in A2780 cells, suggesting that this compound has a general effect to inhibit VEGF transcriptional activation in ovarian cancer cells. 21893035
MMP-AC0095 VEGFA vascular endothelial growth factor A 7422 Ovarian carcinoma OVCAR-3 - - - - Acacetin treatment inhibited tumor growth with 50% decrease of tumor weight when compared to that from the control group, indicating that acacetin suppresses tumor growth through impeding the angiogenesis. Acacetin inhibited the levels of VEGF expression in tumor tissue samples 21893035