HOME
BROWSE
FLORA
CONTACT
Botanical Name Plant's Common Name Plant Family   

   MMP-AC0096 : Baicalein

 
Compound Name  :
Baicalein		  
  Compound Class  : Flavonoid  
  Synonyms  : baicalein; 491-67-8; 5,6,7-Trihydroxyflavone; 5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one; Biacalein;

  
  Compound Extracted from  : Baicalein is extracted / reported from 3 Plant(s) of Melghat Flora as below


 
 
Molecular Formula  :
C15H10O5		  
  Molecular Weight  : 270.24  
  InChi Key  :  
  IUPAC  :  
  InChi  :  
  Hydrogen Bond Donor count  : 3  
  Hydrogen Bond Acceptor count  : 5  
  Rotational Bond count  : 1  
  TPSA  : 87  
  LogP Value  :

 1.7

  
 
Lipinski Rule of Five  :
Yes		  
  Ghose Filter  : Yes  
  Veber Filter  : Yes  
  Muegge Filter  :

 Yes

  
 
PubChem CID  :
5281605		  
  Drugbank ID  : -  
  Super Natural  : -  
  CTD  : C006680  
  HIT  : C0392  
  NCI-60 GI50 data  :

 491-67-8

  
 
Reference(s)  :
https://www.ncbi.nlm.nih.gov/pubmed/27780710

  

Compound_ID Cell Lines Cancer Type IC50 Value EC50 Value ED50 Value GI50 Value References
MMP-AC0096 26-L5 Colon 38.5 痢/ml - - - 11411569
MMP-AC0096 26-L5 Colon 2.57 痢/ml - - - 11411569
MMP-AC0096 HL-60 Haematopoietic and Lymphoid tissue 260 ng/ml - - - 8084211
MMP-AC0096 Molt-4 Haematopoietic and Lymphoid tissue 2,320 ng/ml - - - 8084211

Compound_ID Target Gene_Name Gene_ID Cancer Cell_lines IC50 Value EC50 Value ED50 Value GI50 Value Remarks References
MMP-AC0096 ALOX12 arachidonate 12-lipoxygenase 239 Lung Cancer H-460 - - - - Baicalein suppressed the 12-Lipoxygenase protein expression after treatment with baicalein for 8 h.12-Lipoxygenase converts arachidonic acid to 12(S)-hydroxyeicosatetraenoic acid (HETE), a bioactive lipid implicated in tumor angiogenesis, growth and metastasis. Therefore, 12-LOX may play a role in the progression of cancer in human tissue, and its inhibitors may become anticancer agents in human cancer. 17050058
MMP-AC0096 BAX BCL2-associated X protein 581 Lung Cancer H-460 - - - - After treating the H460 cells with 50 然 baicalein for 4 h, the results showed a marked upregulation of the Bax protein. 17050058
MMP-AC0096 BCL2 B-cell CLL/lymphoma 2 596 Lung Cancer H-460 - - - - After treating the H460 cells with 50 然 baicalein for 4 h, the results showed a marked downregulation of expression of the Bcl-2 protein. 17050058
MMP-AC0096 BCL2 B-cell CLL/lymphoma 2 596 Lung squamous Carcinoma CH27 - - - - The expression of Bcl-2 proform were significantly decreased after treatment with baicalein for 8 h. 15868934
MMP-AC0096 CASP3 caspase 3, apoptosis-related cysteine peptidase 836 Human promyelocytic leukemia HL-60 - - - - Baicalein induced HL-60 apoptosis via promoted caspase-3 pathway.The results indicate that activation of caspase 3 contributes to baicalein-induced apoptosis. 14630128
MMP-AC0096 CASP3 caspase 3, apoptosis-related cysteine peptidase 836 Lung Cancer H-460 - - - - Proform of caspase-3 was significantly decreased after treatment with 50 lM baicalein for 4. 17050058
MMP-AC0096 CASP3 caspase 3, apoptosis-related cysteine peptidase 836 Lung squamous Carcinoma CH27 - - - - The expression of Caspase-3 proform were significantly decreased after treatment with baicalein for 8 h. 15868934
MMP-AC0096 CCNB1 cyclin B1 891 Lung Cancer H-460 - - - - Levels of Cyclin B1 protein was decreased during 50 然 baicalein treatment 24 . 17050058
MMP-AC0096 CCNB1 cyclin B1 891 Lung squamous Carcinoma CH27 - - - - The level of cyclin B1 protein was decreased during 50 然 baicalein treatment for 24 h. Their data indicated that G2/M-phase-regulating cyclin B1 are expressed at low levels in baicalein-induced apoptosis. The modifications of these cell cycle-associated proteins induced by baicalein appear to perturb the cell progression through the S-phase. 15868934
MMP-AC0096 CCND1 cyclin D1 595 Lung squamous Carcinoma CH27 - - - - The level of cyclin D1 protein was decreased during 50然 baicalein treatment for 24 h .Their data indicated that G0/G1-phase-regulating proteins cyclin D1 and cdk 4 expressed at low levels in baicalein-induced apoptosis. The modifications of these cell cycle-associated proteins induced by baicalein appear to perturb the cell progression through the S-phase. 15868934
MMP-AC0096 CDK1 cyclin-dependent kinase 1 983 Lung Cancer H-460 - - - - Levels of CDK1 protein was decreased during 50 然 baicalein treatment 24 . 17050058
MMP-AC0096 CDK4 cyclin-dependent kinase 4 1019 Lung squamous Carcinoma CH27 - - - - The level of cdk4 protein was decreased during 50然 baicalein treatment for 24 h .Their data indicated that G0/G1-phase-regulating proteins cyclin D1 and cdk 4 expressed at low levels in baicalein-induced apoptosis. The modifications of these cell cycle-associated proteins induced by baicalein appear to perturb the cell progression through the S-phase. 15868934
MMP-AC0096 PARP1 poly (ADP-ribose) polymerase 1 142 Human promyelocytic leukemia HL-60 - - - - Baicalein promoted caspase-3 activity then leading to cleavage of poly-ADP-ribose polymerase finally leading to DNA fragmentation occurrence. 14630128
MMP-AC0096 TP53 tumor protein p53 7157 Lung Cancer H-460 - - - - Baicalein increased p53 protein in H460 cells up to 24 h in an incubation time-dependent manner. 17050058