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Botanical Name Plant's Common Name Plant Family   

   MMP-AC0099 : (+)-Gallocatechin

 
Compound Name  :
(+)-Gallocatechin		  
  Compound Class  : Flavonoid  
  Synonyms  : Gallocatechin; (+)-Gallocatechin; Gallocatechol; 970-73-0; (+)-gallocatechol;

  
  Compound Extracted from  : (+)-Gallocatechin is extracted / reported from 1 Plant(s) of Melghat Flora as below


 
 
Molecular Formula  :
C15H14O7		  
  Molecular Weight  : 306.27  
  InChi Key  :  
  IUPAC  :  
  InChi  :  
  Hydrogen Bond Donor count  : 6  
  Hydrogen Bond Acceptor count  : 7  
  Rotational Bond count  : 1  
  TPSA  : 131  
  LogP Value  :

 0

  
 
Lipinski Rule of Five  :
No		  
  Ghose Filter  : Yes  
  Veber Filter  : Yes  
  Muegge Filter  :

 No

  
 
PubChem CID  :
65084		  
  Drugbank ID  : -  
  Super Natural  : -  
  CTD  : -  
  HIT  : C0439  
  NCI-60 GI50 data  :

 970-73-0

  
 
Reference(s)  :
https://www.ncbi.nlm.nih.gov/pubmed/24973642

  

Compound_ID Cell Lines Cancer Type IC50 Value EC50 Value ED50 Value GI50 Value References
MMP-AC0099 MCF-7 Breast - 186.6±21.1 µM - - 17602653
MMP-AC0099 Caco-2 Colon - 291.2±1.0 µM - - 17602653
MMP-AC0099 Hep G2 Liver - 202.3±42.9 µM - - 17602653

Compound_ID Target Gene_Name Gene_ID Cancer Cell_lines IC50 Value EC50 Value ED50 Value GI50 Value Remarks References
MMP-AC0099 ALPP alkaline phosphatase, placental 250 Human Carcinoma CeHa - - - - Elevated levels of serum alkaline phosphatase (ALP) in the N- nitrosodiethylamine administered group were significantly reduced by Emblica officinalis (E. officinalis) polyphenol fraction (EOP) treatment. 12866570
MMP-AC0099 ALPP alkaline phosphatase, placental 250 Dalton'sLymphoma Ascites (DLA) - - - - - Elevated levels of serum alkaline phosphatase (ALP) in the N- nitrosodiethylamine administered group were significantly reduced by Emblica officinalis (E. officinalis) polyphenol fraction (EOP) treatment. 12866570
MMP-AC0099 CDC25C cell division cycle 25 homolog C (S. pombe) 995 Human Carcinoma CeHa 15 µg/mL. - - - Emblica officinalis (E. officinalis) polyphenol fraction (EOP) inhibited the activity of cdc25 tyrosine phosphatase, an important enzyme involved in cell cycle regulation. This enzyme is a critical regulator of M phase promoting factor (MPF), which removes inhibitory phosphates in the catalytic domain of p34cdc2 thereby directly controls the entry of cells into M phase. 12866570
MMP-AC0099 CDC25C cell division cycle 25 homolog C (S. pombe) 995 Dalton'sLymphoma Ascites (DLA) - 15 µg/ml - - - Emblica officinalis (E. officinalis) polyphenol fraction (EOP) inhibited the activity of cdc25 tyrosine phosphatase, an important enzyme involved in cell cycle regulation. This enzyme is a critical regulator of M phase promoting factor (MPF), which removes inhibitory phosphates in the catalytic domain of p34cdc2 thereby directly controls the entry of cells into M phase. 12866570
MMP-AC0099 GGT1 gamma-glutamyltransferase 1 2678 Human Carcinoma CeHa - - - - Gamma-glutamyl transpeptidase activity was raised to 88.4 ± 16.2 U/l in serum of N- nitrosodiethylamine treated group was reduced to 48.4 ± 14.8 U/l by Emblica officinalis (E. officinalis) polyphenol fraction (EOP) treatment. 12866570
MMP-AC0099 GGT1 gamma-glutamyltransferase 1 2678 Dalton'sLymphoma Ascites (DLA) - - - - - Gamma-glutamyl transpeptidase activity was raised to 88.4 ± 16.2 U/l in serum of N- nitrosodiethylamine treated group was reduced to 48.4 ± 14.8 U/l by Emblica officinalis (E. officinalis) polyphenol fraction (EOP) treatment. 12866570
MMP-AC0099 GPT glutamic-pyruvate transaminase (alanine aminotransferase) 2875 Human Carcinoma CeHa - - - - Elevated levels of serum glutamate pyruvate transaminase (GPT), in the N- nitrosodiethylamine administered group were significantly reduced by Emblica officinalis (E. officinalis) polyphenol fraction (EOP) treatment. 12866570
MMP-AC0099 GPT glutamic-pyruvate transaminase (alanine aminotransferase) 2875 Dalton'sLymphoma Ascites (DLA) - - - - - Elevated levels of serum glutamate pyruvate transaminase (GPT), in the NDEA administered group were significantly reduced by Emblica officinalis (E. officinalis) polyphenol fraction (EOP) treatment. 12866570
MMP-AC0099 STM1 glutathione S-transferase mu 1 2944 Dalton'sLymphoma Ascites (DLA) - - - - - Elevated levels of liver glutathione S- transferase (GST) level in the N- nitrosodiethylamine administered group were significantly reduced by Emblica officinalis (E. officinalis) polyphenol fraction (EOP) treatment. 12866570
MMP-AC0099 GSTM1 glutathione S-transferase mu 1 2944 Human Carcinoma CeHa - - - - Elevated levels of liver glutathione S- transferase (GST) level in the N- nitrosodiethylamine administered group were significantly reduced by Emblica officinalis (E. officinalis) polyphenol fraction (EOP) treatment. 12866570
MMP-AC0099 TOP2A topoisomerase (DNA) II alpha 170kDa 7153 Human Carcinoma CeHa - - - - Emblica officinalis (E. officinalis) polyphenol fraction (EOP) was found to inhibit the activity of topoisomerase II in Sacchromyces cerviacae mutant cell cultures. Cancer cells have higher topoisomerase II levels. Therefore, inhibition of this enzyme is a likely target for therapeutic intervention and may suppress cell proliferation. 12866570
MMP-AC0099 TOP2A topoisomerase (DNA) II alpha 170kDa 7153 Dalton'sLymphoma Ascites (DLA) - - - - - Emblica officinalis (E. officinalis) polyphenol fraction (EOP) was found to inhibit the activity of topoisomerase II in Sacchromyces cerviacae mutant cell cultures. Cancer cells have higher topoisomerase II levels. Therefore, inhibition of this enzyme is a likely target for therapeutic intervention and may suppress cell proliferation. 12866570