Compound_ID |
Target |
Gene_Name |
Gene_ID |
Cancer |
Cell_lines |
IC50 Value |
EC50 Value |
ED50 Value |
GI50 Value |
Remarks |
References |
MMP-AC0100 |
APAF1 |
apoptotic peptidase activating factor 1 |
317 |
preneoplastic epidermal keratinocytes |
JB6 C141 |
- |
- |
- |
- |
Silymarin-induced apoptosis in JB6 C141 cells primarily mediated through a p53-dependent pathway, and p53-independent pathway seems to have a minor role. p53-dependent pathway involves the protein Apaf-1. |
15713892 |
MMP-AC0100 |
BAX |
BCL2-associated X protein |
581 |
preneoplastic epidermal keratinocytes |
JB6 C141 |
- |
- |
- |
- |
Silymarin-induced apoptosis in JB6 C141 cells primarily mediated through a p53-dependent pathway, and p53-independent pathway seems to have a minor role. p53-dependent pathway involves the proteins of Bcl-2 family. |
15713892 |
MMP-AC0100 |
BCL2 |
B-cell CLL/lymphoma 2 |
596 |
preneoplastic epidermal keratinocytes |
JB6 C141 |
- |
- |
- |
- |
Silymarin-induced apoptosis in JB6 C141 cells primarily mediated through a p53-dependent pathway, and p53-independent pathway seems to have a minor role. p53-dependent pathway involves the proteins of Bcl-2 family. |
15713892 |
MMP-AC0100 |
BCL2L1 |
BCL2-like 1 |
598 |
preneoplastic epidermal keratinocytes |
JB6 C141 |
- |
- |
- |
- |
Silymarin-induced apoptosis in JB6 C141 cells primarily mediated through a p53-dependent pathway, and p53-independent pathway seems to have a minor role. p53-dependent pathway involves the proteins of Bcl-2 family. |
15713892 |
MMP-AC0100 |
CASP3 |
caspase 3, apoptosis-related cysteine peptidase |
836 |
preneoplastic epidermal keratinocytes |
JB6 C141 |
- |
- |
- |
- |
Silymarin-induced apoptosis in JB6 C141 cells primarily mediated through a p53-dependent pathway, and p53-independent pathway seems to have a minor role. p53-dependent pathway involves the activation of caspase-3. |
15713892 |
MMP-AC0100 |
CYCS |
cytochrome c |
54205 |
preneoplastic epidermal keratinocytes |
JB6 C141 |
- |
- |
- |
- |
Silymarin-induced apoptosis in JB6 C141 cells primarily mediated through a p53-dependent pathway, and p53-independent pathway seems to have a minor role. p53-dependent pathway involves the protein cytochrome c. |
15713892 |
MMP-AC0100 |
PARP1 |
poly (ADP-ribose) polymerase 1 |
142 |
preneoplastic epidermal keratinocytes |
JB6 C141 |
- |
- |
- |
- |
Silymarin-induced apoptosis in JB6 C141 cells primarily mediated through a p53-dependent pathway, and p53-independent pathway seems to have a minor role. p53-dependent pathway involves the activation of PARP. |
15713892 |
MMP-AC0100 |
TP53 |
tumor protein p53 |
7157 |
preneoplastic epidermal keratinocytes |
JB6 C141 |
- |
- |
- |
- |
Silymarin-induced apoptosis in JB6 C141 cells primarily mediated through a p53-dependent pathway, and p53-independent pathway seems to have a minor role. |
15713892 |