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Botanical Name Plant's Common Name Plant Family   

   MMP-AC0101 : Stigmasterol

 
Compound Name  :
Stigmasterol		  
  Compound Class  : Steroids  
  Synonyms  : STIGMASTEROL; Stigmasterin; 83-48-7; beta-Stigmasterol; Stigmasta-5,22-dien-3beta-ol;

  
  Compound Extracted from  : Stigmasterol is extracted / reported from 63 Plant(s) of Melghat Flora as below

MC008: Butea superba Roxb.;
MC052: Dioscorea belophylla (Prain) Voigt ex Haines;
MC053: Dioscorea bulbifera L.;
MG022: Dichanthium annulatum (Forssk.) Stapf;
MH013: Polycarpaea corymbosa (L.) Lam.;
MH024: Corchorus olitorius L.;
MH028: Tribulus terrestris L.;
MH061: Psoralea corylifolia L.;
MH062: Rhynchosia minima (L.) DC.;
MH085: Glinus oppositifolius (L.) Aug.DC.;
MH087: Trianthema portulacastrum L.;
MH109: Centratherum anthelminticum (L.) O. Ketz.;
MH133: Sphaeranthus indicus L.;
MH134: Spilanthes calva DC.;
MH138: Vernonia cinerea (L.) Less;
MH159: Convolvulus arvensis L;
MH173: Physalis minima L.;
MH203: Hygrophila auriculata (Schumach.) Heine;
MH212: Lepidagathis trinervis Nees;
MH216: Phyla nodiflora (L.) Greene;
MH223: Leucas cephalotes (Roth) Spreng.;
MH231: Plectranthus mollis (Aiton) Spreng. ;
MH239: Amaranthus spinosus L.;
MH241: Alternanthera sessilis (L.) R.Br. ex DC.;
MH258: Euphorbia hirta L.;
MH262: Euphorbia thymifolia L. ;
MH293: Commelina benghalensis L.;
MH299: Murdannia nudiflora (L.) Brenan;
MH329: Sphaeranthus africanus L.;
MH333: Tricholepis glaberrima DC.;
MH337: Anagallis arvensis L.;
MH345: Sida rhombifolia Linn;
MH353: Chlorophytum arundinaceum Baker;
MH439: Arisaema leschenaultii Blume;
MH455: Baccharoides anthelmintica (L.) Moench;
MS011: Sida acuta Burm. f.;
MS012: Sida glutinosa Roxb.;
MS029: Abrus precatorius L.;
MS030: Aeschynomene indica L.;
MS034: Crotalaria spectabilis Roth.;
MS048: Caesalpinia decapetala (Roth) Alston;
MS055: Hamiltonia suaveolens (Roxb.) Roxb.;
MS067: Leptadenia reticulata (Retz.) Wight;
MS074: Solanum violaceum Ortega;
MS081: Clerodendrum serratum (L.) Moon;
MS086: Anisomeles indica (L.) Kuntze;
MS090: Pupalia lappacea (L.) Juss.;
MS091: Dendrophthoe falcata (L.f.) Ettingsh.;
MS095: Jatropha curcas L.;
MS101: Solanum torvum Sw.;
MS132: Acacia jacquemontii Benth;
MT020: Ziziphus mauritiana Lam.;
MT032: Erythrina suberosa Roxb.;
MT034: Pongamia pinnata (L.)Pierre;
MT035: Pterocarpus marsupium Roxb.;
MT043: Albizia lebbeck (L.) Benth.;
MT066: Wrightia tinctoria Roem.;
MT069: Cordia macleodii Hook. fil. & Thoms.;
MT081: Holoptelea integrifolia Planch.;
MT088: Ficus racemosa L.;
MT089: Ficus religiosa L.;
MT095: Magnolia champaca (L.) Baill. ex Pierre.;
MT102: Adansonia digitata L. ;

  
 
Molecular Formula  :
C29H48O		  
  Molecular Weight  : 412.7  
  InChi Key  :  
  IUPAC  :  
  InChi  :  
  Hydrogen Bond Donor count  : 1  
  Hydrogen Bond Acceptor count  : 1  
  Rotational Bond count  : 5  
  TPSA  : 20.2  
  LogP Value  :

 8.6

  
 
Lipinski Rule of Five  :
No		  
  Ghose Filter  : No  
  Veber Filter  : Yes  
  Muegge Filter  :

 No

  
 
PubChem CID  :
5280794		  
  Drugbank ID  : -  
  Super Natural  : 000083487  
  CTD  : D013265  
  HIT  : -  
  NCI-60 GI50 data  :

 -

  
 
Reference(s)  :
https://www.ncbi.nlm.nih.gov/pubmed/22850319

  

Compound_ID Cell Lines Cancer Type IC50 Value EC50 Value ED50 Value GI50 Value References
MMP-AC0101 RAW264 Haematopoietic and Lymphoid tissue 2.1±0.4 µM - - - 21372424
MMP-AC0101 HL-60 Haematopoietic and Lymphoid tissue 52.50 µg/ml - - - 21953905

Compound_ID Target Gene_Name Gene_ID Cancer Cell_lines IC50 Value EC50 Value ED50 Value GI50 Value Remarks References
MMP-AC0101 NOS2 nitric oxide synthase 2, inducible 4843 Murine monocyte/macrophage line derived from ascitic tumour induced with Abelson leukaemai virus Raw264 1.2±0.4 µM - - - TNF-a suppressive alkaloids also inhibited NO production in RAW264 cell. 21372424
MMP-AC0101 TNF tumor necrosis factor 7124 Murine monocyte/macrophage line derived from ascitic tumour induced with Abelson leukaemai virus Raw264 2.1±0.4 µM - - - Lycorine suppressed the TNF-a production in LPS-stimulated RAW264 cells 21372424