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Botanical Name Plant's Common Name Plant Family   

   MMP-AC0105 : Farnesol

 
Compound Name  :
Farnesol		  
  Compound Class  : Terpenoids  
  Synonyms  : farnesol; trans,trans-Farnesol; (E,E)-Farnesol; 106-28-5; trans-Farnesol;

  
  Compound Extracted from  : Farnesol is extracted / reported from 2 Plant(s) of Melghat Flora as below


 
 
Molecular Formula  :
C15H26O		  
  Molecular Weight  : 222.37  
  InChi Key  :  
  IUPAC  :  
  InChi  :  
  Hydrogen Bond Donor count  : 1  
  Hydrogen Bond Acceptor count  : 1  
  Rotational Bond count  : 7  
  TPSA  : 20.2  
  LogP Value  :

 4.8

  
 
Lipinski Rule of Five  :
Yes		  
  Ghose Filter  : Yes  
  Veber Filter  : Yes  
  Muegge Filter  :

 Yes

  
 
PubChem CID  :
445070		  
  Drugbank ID  : DB02509  
  Super Natural  : 004602840  
  CTD  : D005204  
  HIT  : C0241  
  NCI-60 GI50 data  :

 4602-84-0

  
 
Reference(s)  :
https://www.ncbi.nlm.nih.gov/pubmed/22580194

  

Compound_ID Cell Lines Cancer Type IC50 Value EC50 Value ED50 Value GI50 Value References
MMP-AC0105 B16(F10) Skin 50 µMol/L - - - 9164984

Compound_ID Target Gene_Name Gene_ID Cancer Cell_lines IC50 Value EC50 Value ED50 Value GI50 Value Remarks References
MMP-AC0105 ATF3 activating transcription factor 3 467 Lung Cancer H-460 - - - - The analysis showed that FOH induced the expression of a great number of genes typically associated with ER stress response signaling, including ATF3. 17699800
MMP-AC0105 CASP3 caspase 3, apoptosis-related cysteine peptidase 836 Lung Cancer H-460 - - - - Examination of caspase activation in FOH-treated H460 cells showed that caspase-3 was significantly activated at 4 h, similar to the time course of poly(ADP-ribose) polymerase (PARP) cleavage. 17699800
MMP-AC0105 CASP9 caspase 9, apoptosis-related cysteine peptidase 842 Lung Cancer H-460 - - - - Examination of caspase activation in FOH-treated H460 cells showed that caspase-9 were significantly activated at 4 h, similar to the time course of poly(ADP-ribose) polymerase (PARP) cleavage. 17699800
MMP-AC0105 EGR1 early growth response 1 1958 Lung Cancer H-460 - - - - FOH also induces the expression of several members of the Egr family, transcription factors that are important regulators of apoptosis and cell proliferation including Egr1. 17699800
MMP-AC0105 FOS FBJ murine osteosarcoma viral oncogene homolog 2353 Lung Cancer H-460 - - - - The expression of several members of the Fos were also greatly upregulated witht the FOH treatment. 17699800
MMP-AC0105 JUN jun proto-oncogene 3725 Lung Cancer H-460 - - - - The expression of several members of the Jun were also greatly upregulated with the FOH treatment. 17699800
MMP-AC0105 MAPK1 mitogen-activated protein kinase 1 5594 Lung Cancer H-460 - - - - Treatment of H460 cells with FOH induced the level of phosphorylated ERK, p38, and JNK. 17699800
MMP-AC0105 MAPK8 mitogen-activated protein kinase 8 5599 Lung Cancer H-460 - - - - Treatment of H460 cells with FOH induced the level of phosphorylated ERK, p38, and JNK. 17699800