Botanical Name Plant's Common Name Plant Family   

   MMP-AC0112 : Alpha-curcumene

 
Compound Name  :

Alpha-curcumene
 
  Compound Class  : Terpenoids  
  Synonyms  : alpha-Curcumene; Curcumene; Ar-Curcumene; 2-Methyl-6-p-tolyl-2-heptene; aryl-curcumene;

 
  Compound Extracted from  : Alpha-curcumene is extracted / reported from 1 Plant(s) of Melghat Flora as below


 
 
Molecular Formula  :

C15H22
 
  Molecular Weight  : 202.33  
  InChi Key  :  
  IUPAC  :  
  InChi  :  
  Hydrogen Bond Donor count  : 0  
  Hydrogen Bond Acceptor count  : 0  
  Rotational Bond count  : 4  
  TPSA  : 0  
  LogP Value  :

5.4

 
 
Lipinski Rule of Five  :

No
 
  Ghose Filter  : Yes  
  Veber Filter  : Yes  
  Muegge Filter  :

No

 
 
PubChem CID  :

92139
 
  Drugbank ID  : -  
  Super Natural  : -  
  CTD  : C086829  
  HIT  : -  
  NCI-60 GI50 data  :

-

 
 
Reference(s)  :

https://www.ncbi.nlm.nih.gov/pubmed/19118501


 

Compound_ID Cell Lines Cancer Type IC50 Value EC50 Value ED50 Value GI50 Value References
MMP-AC0112 K-562 Haematopoietic and Lymphoid tissue 256.5 µM - - - 18776670
MMP-AC0112 LNCaP Prostate 277.5 µM - - - 18776670

Compound_ID Target Gene_Name Gene_ID Cancer Cell_lines IC50 Value EC50 Value ED50 Value GI50 Value Remarks References
MMP-AC0112 CASP3 caspase 3, apoptosis-related cysteine peptidase 836 Human promyelocytic leukemia HL-60 - - - - Alpha-Curcumene activated caspases 3 after 3 h 22575162
MMP-AC0112 CASP7 caspase 7, apoptosis-related cysteine peptidase 840 Human promyelocytic leukemia HL-60 - - - - Alpha-Curcumene activated caspases 7 after 3 h 22575162
MMP-AC0112 CASP8 caspase 8, apoptosis-related cysteine peptidase 841 Human promyelocytic leukemia HL-60 - - - - Alpha-Curcumene activated caspases 8 after 1 h 22575162
MMP-AC0112 CASP9 caspase 9, apoptosis-related cysteine peptidase 842 Human promyelocytic leukemia HL-60 - - - - Alpha-Curcumene activated caspases caspases 9 after 12 h 22575162