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Botanical Name Plant's Common Name Plant Family   

   MMP-AC0118 : Menthol

 
Compound Name  :
Menthol		  
  Compound Class  : Terpenoids  
  Synonyms  : MENTHOL; dl-Menthol; 1490-04-6; 2-Isopropyl-5-methylcyclohexanol; Menthyl alcohol;

  
  Compound Extracted from  : Menthol is extracted / reported from 2 Plant(s) of Melghat Flora as below


 
 
Molecular Formula  :
C10H20O		  
  Molecular Weight  : 156.26  
  InChi Key  :  
  IUPAC  :  
  InChi  :  
  Hydrogen Bond Donor count  : 3  
  Hydrogen Bond Acceptor count  : 1  
  Rotational Bond count  : 1  
  TPSA  : 20.2  
  LogP Value  :

 3

  
 
Lipinski Rule of Five  :
Yes		  
  Ghose Filter  : No  
  Veber Filter  : Yes  
  Muegge Filter  :

 No

  
 
PubChem CID  :
1254		  
  Drugbank ID  : DB00825  
  Super Natural  : 000089781  
  CTD  : D008610  
  HIT  : C0347  
  NCI-60 GI50 data  :

 -

  
 
Reference(s)  :
https://www.ncbi.nlm.nih.gov/pubmed/24594507

  

Compound_ID Cell Lines Cancer Type IC50 Value EC50 Value ED50 Value GI50 Value References
MMP-AC0118 B16 Skin 250 µMol/L - - - 11741740

Compound_ID Target Gene_Name Gene_ID Cancer Cell_lines IC50 Value EC50 Value ED50 Value GI50 Value Remarks References
MMP-AC0118 NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 4790 Gastric Carcinoma SNU-5 - - - - Western blot D427 analysis revealed that (-)-Menthol treatment decreased topoisomeraseI, IIalpha;IIbeta and NF-? B protein levels. Menthol treatment decreased topoisomerase I, IIalphaIIIalpha;IIIbeta?and NF-? B levels of gene expression. The effects of (-)-Menthol on the gene expression of topoisomerase I, IIalpha;IIbeta;IIIalpha;IIIbeta?and NF-? B from SNU-5 cells were also confirmed by cDNA microarray. 16158947
MMP-AC0118 RAP1A RAP1A, member of RAS oncogene family 5906 Leukemia K-562 - - - - Menthol was found to decrease the up-regulation of Rap1a. 12671036
MMP-AC0118 RHOB ras homolog family member B 388 Leukemia K-562 - - - - Menthol was found to decrease the up-regulation of RhoB induced by Lov. 12671036
MMP-AC0118 TOP1MT topoisomerase (DNA) I 116447 Gastric Carcinoma SNU-5 - - - - Western blot D427 analysis revealed that (-)-Menthol treatment decreased topoisomeraseI, IIalpha;IIbeta and NF-? B protein levels. Menthol treatment decreased topoisomerase I, IIalphaIIIalpha;IIIbeta?and NF-? B levels of gene expression. The effects of (-)-Menthol on the gene expression of topoisomerase I, IIalpha;IIbeta;IIIalpha;IIIbeta?and NF-? B from SNU-5 cells were also confirmed by cDNA microarray. 16158947
MMP-AC0118 TOP2A topoisomerase (DNA) II alpha 170kDa 7153 Gastric Carcinoma SNU-5 - - - - Western blot D427 analysis revealed that (-)-Menthol treatment decreased topoisomeraseI, IIalpha;IIbeta and NF-? B protein levels. Menthol treatment decreased topoisomerase I, IIalphaIIIalpha;IIIbeta?and NF-? B levels of gene expression. The effects of (-)-Menthol on the gene expression of topoisomerase I, IIalpha;IIbeta;IIIalpha;IIIbeta?and NF-? B from SNU-5 cells were also confirmed by cDNA microarray. 16158947
MMP-AC0118 TOP2B topoisomerase (DNA) II beta 180kDa 7155 Gastric Carcinoma SNU-5 - - - - Western blot D427 analysis revealed that (-)-Menthol treatment decreased topoisomeraseI, IIalpha;IIbeta and NF-? B protein levels. Menthol treatment decreased topoisomerase I, IIalphaIIIalpha;IIIbeta?and NF-? B levels of gene expression. The effects of (-)-Menthol on the gene expression of topoisomerase I, IIalpha;IIbeta;IIIalpha;IIIbeta?and NF-? B from SNU-5 cells were also confirmed by cDNA microarray. 16158947