Compound_ID |
Target |
Gene_Name |
Gene_ID |
Cancer |
Cell_lines |
IC50 Value |
EC50 Value |
ED50 Value |
GI50 Value |
Remarks |
References |
MMP-AC0147 |
BAX |
BCL2-associated X protein |
581 |
Prostate Cancer |
PC-3 |
- |
- |
- |
- |
The expressions of two CDK inhibitory proteins (p21 and p27) and two pro-apoptotic Bcl-2 family members (Bax and BNIP3) were markedly elevated. |
21371438 |
MMP-AC0147 |
BCL2 |
B-cell CLL/lymphoma 2 |
596 |
Prostate Cancer |
PC-3 |
- |
- |
- |
- |
geraniol induces apoptosis and cell cycle arrest in vivo |
21371438 |
MMP-AC0147 |
BCL2 |
B-cell CLL/lymphoma 2 |
596 |
Prostate Cancer |
PC-3 |
- |
- |
- |
- |
The expressions Bcl-2 was reduced in the cells treated with geraniol. |
21371438 |
MMP-AC0147 |
BCL2L2 |
BCL2-like 2 |
599 |
Prostate Cancer |
PC-3 |
- |
- |
- |
- |
The expressions Bcl-w was reduced in the cells treated with geraniol. |
21371438 |
MMP-AC0147 |
BNIP3 |
BCL2/adenovirus E1B 19kDa interacting protein 3 |
664 |
Prostate Cancer |
PC-3 |
- |
- |
- |
- |
The expressions of two CDK inhibitory proteins (p21 and p27) and two pro-apoptotic Bcl-2 family members (Bax and BNIP3) were markedly elevated. |
21371438 |
MMP-AC0147 |
CASP3 |
caspase 3, apoptosis-related cysteine peptidase |
836 |
Prostate Cancer |
PC-3 |
- |
- |
- |
- |
Caspase-3 activity was increased in relation to concentrations of geraniol in PC-3 cells. |
21371438 |
MMP-AC0147 |
CCND1 |
cyclin D1 |
595 |
Breast adenocarcinoma |
MCF-7 |
- |
- |
- |
- |
A significant, concentration-dependent decrease in expression of the early G1 phase cyclin D1 was observed in MCF-7 cells treated with geraniol. |
15450939 |
MMP-AC0147 |
CCNE1 |
cyclin E1 |
898 |
Breast adenocarcinoma |
MCF-7 |
- |
- |
- |
- |
Protein levels of cyclin E decreased significantly in cells treated with geraniol at all concentrationSmM b-ionone. |
15450939 |
MMP-AC0147 |
CDK1 |
cyclin-dependent kinase 1 |
983 |
Prostate Cancer |
PC-3 |
- |
- |
- |
- |
The expressions CDK1 was reduced in the cells treated with geraniol. |
21371438 |
MMP-AC0147 |
CDK2 |
cyclin-dependent kinase 2 |
1017 |
Breast adenocarcinoma |
MCF-7 |
- |
- |
- |
- |
Protein levels of CDK 2, decreased significantly in cells treated with geraniol at all concentrations. |
15450939 |
MMP-AC0147 |
CDK4 |
cyclin-dependent kinase 4 |
1019 |
Prostate Cancer |
PC-3 |
- |
- |
- |
- |
The expressions CDK4 was reduced in the cells treated with geraniol. |
21371438 |
MMP-AC0147 |
CDKN1A |
cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
1026 |
Prostate Cancer |
PC-3 |
- |
- |
- |
- |
The expressions of two CDK inhibitory proteins (p21 and p27) and two pro-apoptotic Bcl-2 family members (Bax and BNIP3) were markedly elevated. |
21371438 |
MMP-AC0147 |
CycA |
Cyclin A |
39340 |
Breast adenocarcinoma |
MCF-7 |
- |
- |
- |
- |
Expression of cyclin A, the S phase CDK 2 activator, decreased significantly following treatment of cells with geraniol. |
15450939 |
MMP-AC0147 |
CycA |
Cyclin A |
39340 |
Prostate Cancer |
PC-3 |
- |
- |
- |
- |
The expressions Cyclin A was reduced in the cells treated with geraniol. |
21371438 |
MMP-AC0147 |
CycB |
Cyclin B |
37618 |
Prostate Cancer |
PC-3 |
- |
- |
- |
- |
The expressions Cyclin B was reduced in the cells treated with geraniol. |
21371438 |
MMP-AC0147 |
PSMD9 |
proteasome (prosome, macropain) 26S subunit, non-ATPase, 9 |
5715 |
Prostate Cancer |
PC-3 |
- |
- |
- |
- |
The expressions of two CDK inhibitory proteins (p21 and p27) and two pro-apoptotic Bcl-2 family members (Bax and BNIP3) were markedly elevated. |
21371438 |