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Botanical Name Plant's Common Name Plant Family   

   MMP-AC0153 : Linalool

 
Compound Name  :
Linalool		  
  Compound Class  : Terpenoids  
  Synonyms  : Linalool; 78-70-6; 3,7-Dimethylocta-1,6-dien-3-ol; Linalol; 3,7-Dimethyl-1,6-octadien-3-ol;

  
  Compound Extracted from  : Linalool is extracted / reported from 9 Plant(s) of Melghat Flora as below


 
 
Molecular Formula  :
C10H18O		  
  Molecular Weight  : 154.25  
  InChi Key  :  
  IUPAC  :  
  InChi  :  
  Hydrogen Bond Donor count  : 1  
  Hydrogen Bond Acceptor count  : 1  
  Rotational Bond count  : 4  
  TPSA  : 20.2  
  LogP Value  :

 2.7

  
 
Lipinski Rule of Five  :
Yes		  
  Ghose Filter  : No  
  Veber Filter  : Yes  
  Muegge Filter  :

 No

  
 
PubChem CID  :
6549		  
  Drugbank ID  : -  
  Super Natural  : 001180718  
  CTD  : C018584  
  HIT  : C0305  
  NCI-60 GI50 data  :

 -

  
 
Reference(s)  :
https://www.ncbi.nlm.nih.gov/pubmed/29029310

  

Compound_ID Cell Lines Cancer Type IC50 Value EC50 Value ED50 Value GI50 Value References
MMP-AC0153 HL-60 Haematopoietic and Lymphoid tissue 204.51 µg/ml - - - 20359874
MMP-AC0153 B16 Skin 400 µMol/L - - - 11741740

Compound_ID Target Gene_Name Gene_ID Cancer Cell_lines IC50 Value EC50 Value ED50 Value GI50 Value Remarks References
MMP-AC0153 AKT1 v-akt murine thymoma viral oncogene homolog 1 207 Leukemia Molt-4 - - - - Results revealed that treatment of Molt-4 leukemia cells with linalool (130 M) resulted in a time-dependent increase in mRNA expression of PKB alpha by 15.63 fold 19922762
MMP-AC0153 CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1026 Leukemia Molt-4 - - - - treatment of Molt-4 leukemia cells with linalool (130 M) resulted in a time-dependent increase in mRNA expression of a variety of cyclin-dependent kinase inhibitors, such as p21Waf1/CIP1 (31.4 fold), p27Kip1 (43.0 fold), P57Kip2 (32.46 fold), p15 (4.0 fold) at 12 . 19922762
MMP-AC0153 CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 1027 Leukemia Molt-4 - - - - treatment of Molt-4 leukemia cells with linalool (130 M) resulted in a time-dependent increase in mRNA expression of a variety of cyclin-dependent kinase inhibitors, such as p21Waf1/CIP1 (31.4 fold), p27Kip1 (43.0 fold), P57Kip2 (32.46 fold), p15 (4.0 fold) at 12. 19922762
MMP-AC0153 CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) 1028 Leukemia Molt-4 - - - - treatment of Molt-4 leukemia cells with linalool (130 M) resulted in a time-dependent increase in mRNA expression of a variety of cyclin-dependent kinase inhibitors, such as p21Waf1/CIP1 (31.4 fold), p27Kip1 (43.0 fold), P57Kip2 (32.46 fold), p15 (4.0 fold) at 12 . 19922762
MMP-AC0153 CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 1030 Leukemia Molt-4 - - - - treatment of Molt-4 leukemia cells with linalool (130 M) resulted in a time-dependent increase in mRNA expression of a variety of cyclin-dependent kinase inhibitors, such as p21Waf1/CIP1 (31.4 fold), p27Kip1 (43.0 fold), P57Kip2 (32.46 fold), p15 (4.0 fold) at 12. 19922762
MMP-AC0153 CSN2 casein beta 1447 Leukemia Molt-4 - - - - Results revealed that treatment of Molt-4 leukemia cells with linalool (130 M) resulted in a time-dependent increase in mRNA expression of Beta-casein by 14.0 fold 19922762
MMP-AC0153 EDN1 endothelin 1 1906 Leukemia Molt-4 - - - - Results revealed that treatment of Molt-4 leukemia cells with linalool (130 M) resulted in a time-dependent increase in mRNA expression of EDN1 by 26.23 fold 19922762
MMP-AC0153 FN1 fibronectin 1 2335 Leukemia Molt-4 - - - - Results revealed that treatment of Molt-4 leukemia cells with linalool (130 M) resulted in a time-dependent increase in mRNA expression of FN1 by 19.41 fold 19922762
MMP-AC0153 HSPA4 heat shock 70kDa protein 4 3308 Leukemia Molt-4 - - - - Results revealed that treatment of Molt-4 leukemia cells with linalool (130 M) resulted in a time-dependent increase in mRNA expression of Hsp70 by 10.97 fold 19922762
MMP-AC0153 HSPB2 heat shock 27kDa protein 2 3316 Leukemia Molt-4 - - - - Results revealed that treatment of Molt-4 leukemia cells with linalool (130 M) resulted in a time-dependent increase in mRNA expression of HSPB2 by 56.55 fold 19922762
MMP-AC0153 MAPK8 mitogen-activated protein kinase 8 5599 Leukemia Molt-4 - - - - linalool treatment triggered the activation of p53 tumor suppressor and cyclin-dependent kinase inhibitors (such as p21Waf1, p27Kip1, P57Kip2), which results in the induction of GADD45 /JNK signaling pathway. P5. 19922762
MMP-AC0153 MDM2 Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse) 4193 Leukemia Molt-4 - - - - Results revealed that treatment of Molt-4 leukemia cells with linalool (130 M) resulted in a time-dependent increase in mRNA expression of MDM2 by 12.46 fold 19922762
MMP-AC0153 MYC v-myc myelocytomatosis viral oncogene 4609 Leukemia Molt-4 - - - - Results revealed that treatment of Molt-4 leukemia cells with linalool (130 M) resulted in a time-dependent increase in mRNA expression of c-Myc by 50.48 fold 19922762
MMP-AC0153 TP53 tumor protein p53 7157 Leukemia Molt-4 - - - - linalool treatment triggered the activation of p53 tumor suppressorwhich results in the induction of GADD45 /JNK signaling pathway. P5. 19922762
MMP-AC0153 WSB1 WD repeat and SOCS box containing 1 26118 Leukemia Molt-4 - - - - Results revealed that treatment of Molt-4 leukemia cells with linalool (130 M) resulted in a time-dependent increase in mRNA expression of SWIP-1/DKFZp564A122 by 32.73 fold 19922762