Compound_ID |
Target |
Gene_Name |
Gene_ID |
Cancer |
Cell_lines |
IC50 Value |
EC50 Value |
ED50 Value |
GI50 Value |
Remarks |
References |
MMP-AC0153 |
AKT1 |
v-akt murine thymoma viral oncogene homolog 1 |
207 |
Leukemia |
Molt-4 |
- |
- |
- |
- |
Results revealed that treatment of Molt-4 leukemia cells with linalool (130 M) resulted in a time-dependent increase in mRNA expression of PKB alpha by 15.63 fold |
19922762 |
MMP-AC0153 |
CDKN1A |
cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
1026 |
Leukemia |
Molt-4 |
- |
- |
- |
- |
treatment of Molt-4 leukemia cells with linalool (130 M) resulted in a time-dependent increase in mRNA expression of a variety of cyclin-dependent kinase inhibitors, such as p21Waf1/CIP1 (31.4 fold), p27Kip1 (43.0 fold), P57Kip2 (32.46 fold), p15 (4.0 fold) at 12 . |
19922762 |
MMP-AC0153 |
CDKN1B |
cyclin-dependent kinase inhibitor 1B (p27, Kip1) |
1027 |
Leukemia |
Molt-4 |
- |
- |
- |
- |
treatment of Molt-4 leukemia cells with linalool (130 M) resulted in a time-dependent increase in mRNA expression of a variety of cyclin-dependent kinase inhibitors, such as p21Waf1/CIP1 (31.4 fold), p27Kip1 (43.0 fold), P57Kip2 (32.46 fold), p15 (4.0 fold) at 12. |
19922762 |
MMP-AC0153 |
CDKN1C |
cyclin-dependent kinase inhibitor 1C (p57, Kip2) |
1028 |
Leukemia |
Molt-4 |
- |
- |
- |
- |
treatment of Molt-4 leukemia cells with linalool (130 M) resulted in a time-dependent increase in mRNA expression of a variety of cyclin-dependent kinase inhibitors, such as p21Waf1/CIP1 (31.4 fold), p27Kip1 (43.0 fold), P57Kip2 (32.46 fold), p15 (4.0 fold) at 12 . |
19922762 |
MMP-AC0153 |
CDKN2B |
cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) |
1030 |
Leukemia |
Molt-4 |
- |
- |
- |
- |
treatment of Molt-4 leukemia cells with linalool (130 M) resulted in a time-dependent increase in mRNA expression of a variety of cyclin-dependent kinase inhibitors, such as p21Waf1/CIP1 (31.4 fold), p27Kip1 (43.0 fold), P57Kip2 (32.46 fold), p15 (4.0 fold) at 12. |
19922762 |
MMP-AC0153 |
CSN2 |
casein beta |
1447 |
Leukemia |
Molt-4 |
- |
- |
- |
- |
Results revealed that treatment of Molt-4 leukemia cells with linalool (130 M) resulted in a time-dependent increase in mRNA expression of Beta-casein by 14.0 fold |
19922762 |
MMP-AC0153 |
EDN1 |
endothelin 1 |
1906 |
Leukemia |
Molt-4 |
- |
- |
- |
- |
Results revealed that treatment of Molt-4 leukemia cells with linalool (130 M) resulted in a time-dependent increase in mRNA expression of EDN1 by 26.23 fold |
19922762 |
MMP-AC0153 |
FN1 |
fibronectin 1 |
2335 |
Leukemia |
Molt-4 |
- |
- |
- |
- |
Results revealed that treatment of Molt-4 leukemia cells with linalool (130 M) resulted in a time-dependent increase in mRNA expression of FN1 by 19.41 fold |
19922762 |
MMP-AC0153 |
HSPA4 |
heat shock 70kDa protein 4 |
3308 |
Leukemia |
Molt-4 |
- |
- |
- |
- |
Results revealed that treatment of Molt-4 leukemia cells with linalool (130 M) resulted in a time-dependent increase in mRNA expression of Hsp70 by 10.97 fold |
19922762 |
MMP-AC0153 |
HSPB2 |
heat shock 27kDa protein 2 |
3316 |
Leukemia |
Molt-4 |
- |
- |
- |
- |
Results revealed that treatment of Molt-4 leukemia cells with linalool (130 M) resulted in a time-dependent increase in mRNA expression of HSPB2 by 56.55 fold |
19922762 |
MMP-AC0153 |
MAPK8 |
mitogen-activated protein kinase 8 |
5599 |
Leukemia |
Molt-4 |
- |
- |
- |
- |
linalool treatment triggered the activation of p53 tumor suppressor and cyclin-dependent kinase inhibitors (such as p21Waf1, p27Kip1, P57Kip2), which results in the induction of GADD45 /JNK signaling pathway. P5. |
19922762 |
MMP-AC0153 |
MDM2 |
Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse) |
4193 |
Leukemia |
Molt-4 |
- |
- |
- |
- |
Results revealed that treatment of Molt-4 leukemia cells with linalool (130 M) resulted in a time-dependent increase in mRNA expression of MDM2 by 12.46 fold |
19922762 |
MMP-AC0153 |
MYC |
v-myc myelocytomatosis viral oncogene |
4609 |
Leukemia |
Molt-4 |
- |
- |
- |
- |
Results revealed that treatment of Molt-4 leukemia cells with linalool (130 M) resulted in a time-dependent increase in mRNA expression of c-Myc by 50.48 fold |
19922762 |
MMP-AC0153 |
TP53 |
tumor protein p53 |
7157 |
Leukemia |
Molt-4 |
- |
- |
- |
- |
linalool treatment triggered the activation of p53 tumor suppressorwhich results in the induction of GADD45 /JNK signaling pathway. P5. |
19922762 |
MMP-AC0153 |
WSB1 |
WD repeat and SOCS box containing 1 |
26118 |
Leukemia |
Molt-4 |
- |
- |
- |
- |
Results revealed that treatment of Molt-4 leukemia cells with linalool (130 M) resulted in a time-dependent increase in mRNA expression of SWIP-1/DKFZp564A122 by 32.73 fold |
19922762 |