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Botanical Name Plant's Common Name Plant Family   

   MMP-AC0156 : Lycopene

 
Compound Name  :
Lycopene		  
  Compound Class  : Terpenoids  
  Synonyms  : LYCOPENE; 502-65-8; Psi,psi-carotene; all-trans-Lycopene; trans-Lycopene;

  
  Compound Extracted from  : Lycopene is extracted / reported from 1 Plant(s) of Melghat Flora as below


 
 
Molecular Formula  :
C40H56		  
  Molecular Weight  : 536.9  
  InChi Key  :  
  IUPAC  :  
  InChi  :  
  Hydrogen Bond Donor count  : 0  
  Hydrogen Bond Acceptor count  : 0  
  Rotational Bond count  : 16  
  TPSA  : 0  
  LogP Value  :

 15.6

  
 
Lipinski Rule of Five  :
No		  
  Ghose Filter  : No  
  Veber Filter  : No  
  Muegge Filter  :

 No

  
 
PubChem CID  :
446925		  
  Drugbank ID  : -  
  Super Natural  : -  
  CTD  : C015329  
  HIT  : -  
  NCI-60 GI50 data  :

 -

  
 
Reference(s)  :
https://www.ncbi.nlm.nih.gov/pubmed/27989599

  

Compound_ID Cell Lines Cancer Type IC50 Value EC50 Value ED50 Value GI50 Value References
MMP-AC0156 HT-29 Colon 10.0 µM - - - 18537129

Compound_ID Target Gene_Name Gene_ID Cancer Cell_lines IC50 Value EC50 Value ED50 Value GI50 Value Remarks References
MMP-AC0156 ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 19 Prostate Cancer LNCaP - - - - increased in the expression of ATP-binding cassette transporter 1 (ABCA1) was only evident 96 h. 21334870
MMP-AC0156 NR1H3 nuclear receptor subfamily 1, group H, member 3 10062 Prostate Cancer LNCaP - - - - lycopene treatment (2.5-10 µM) significantly inhibited the proliferation of LNCaP cells during incubation for 96 h. Lycopene significantly increased the protein and mRNA expression of LXRalpha at 48 h. 21334870
MMP-AC0156 PPARG peroxisome proliferator-activated receptor gamma 5468 Prostate Cancer LNCaP - - - - lycopene treatment (2.5-10 µM) significantly inhibited the proliferation of LNCaP cells during incubation for 96 h. Lycopene significantly increased the protein and mRNA expression of PPAR gamma at 24 and 48 h. 21334870