Compound_ID |
Target |
Gene_Name |
Gene_ID |
Cancer |
Cell_lines |
IC50 Value |
EC50 Value |
ED50 Value |
GI50 Value |
Remarks |
References |
MMP-AC0158 |
CASP3 |
caspase 3, apoptosis-related cysteine peptidase |
836 |
Neuroblastoma |
SK-N-AS |
- |
- |
- |
- |
With the treatment of resveratrol Cancer cell showed increased activity of Caspase-3 with increasing drug concentration, suggesting that this downstream component in the intrinsic apoptotic pathway are activated in response to resveratrol treatment. |
17785572 |
MMP-AC0158 |
CASP8 |
caspase 8, apoptosis-related cysteine peptidase |
841 |
Neuroblastoma |
SK-N-AS |
- |
- |
- |
- |
Procaspase-8 was cleaved in SK-N-AS cells in a time-dependent manner indicated by the appearance of 43- and 41-kDa intermediate cleavage products and an 18-kDa active product |
17785572 |
MMP-AC0158 |
CASP9 |
caspase 9, apoptosis-related cysteine peptidase |
842 |
Neuroblastoma |
SK-N-AS |
- |
- |
- |
- |
With the treatment of resveratrol cancer cell showed increased activity of Caspase-9 with increasing drug concentration, suggesting that this downstream component in the intrinsic apoptotic pathway are activated in response to resveratrol treatment. |
17785572 |
MMP-AC0158 |
CCNB1 |
cyclin B1 |
891 |
Breast adenocarcinoma |
MCF-7; |
- |
- |
- |
- |
Cyclin B1 expression was detectable in and decreased in all cell lines after treatment with resveratrol. |
11895924 |
MMP-AC0158 |
CCND1 |
cyclin D1 |
595 |
Colon Cancer |
SW-480 |
- |
- |
- |
- |
Western blot analysis demonstrated that cyclin A and cyclin B1 expression levels did not change initially but decreased after 24 and 48 h of treatment. Interestingly, cyclin D1 expression decreased after only 2 h of treatment and remained diminished after 24 and 48 h of treatment. A lower dose of resveratrol near the IC50 value (100 M) also decreased cyclin D1 expression significantly at 2, 6, 24, and 48 h. |
11895924 |
MMP-AC0158 |
CTNNBIP1 |
catenin, beta interacting protein 1 |
56998 |
Colon Cancer |
SW-480 |
- |
- |
- |
- |
Beta-Catenin is involved in both colon carcinogenesis and cyclin D1 transcriptional regulation.Cellular extracts were evaluated for -catenin expression after 2, 6, 24, and 48 h of treatment. Western blot analysis demonstrated that Beta-catenin expression did not change initially but decreased after 24 and 48 h of treatment. |
11895924 |
MMP-AC0158 |
CycA |
Cyclin A |
39340 |
Colon Cancer |
SW-480 |
- |
- |
- |
- |
Western blot analysis demonstrated that cyclin A and cyclin B1 expression levels did not change initially but decreased after 24 and 48 h of treatment. Interestingly, cyclin D1 expression decreased after only 2 h of treatment and remained diminished after 24 and 48 h of treatment. A lower dose of resveratrol near the IC50 value (100 M) also decreased cyclin D1 expression significantly at 2, 6, 24, and 48 h. |
11895924 |
MMP-AC0158 |
CYCS |
cytochrome c |
54205 |
Neuroblastoma |
NGP |
- |
- |
- |
- |
Cytochrome c was released into the cytosol at different times after initiating drug treatment. In NGP cells, cytochrome c release occurred after 24 to 48 h |
17785572 |
MMP-AC0158 |
DIABLO |
diablo, IAP-binding mitochondrial protein |
56616 |
Neuroblastoma |
SK-N-AS |
- |
- |
- |
- |
Smac/Diablo was released from the mitochondria with the treatment of compound. |
17785572 |