Botanical Name Plant's Common Name Plant Family   

   MMP-AC0008 : Quercetin

 
Compound Name  :

Quercetin
 
  Compound Class  : Flavonoid  
  Synonyms  : quercetin; 117-39-5; Sophoretin; Xanthaurine; Meletin; Quercetol; Quercetine; Quercitin; Quertine; 3,3',4',5,7-Pentahydroxyflavone; Flavin meletin; 2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one; Cyanidelonon 1522; 3,5,7,3',4'-Pentahydroxyflavone; T-Gelb bzw. grun 1; C.I. Natural Yellow 10; Quercetin content; Kvercetin; Quertin; C.I. Natural red 1;

 
  Compound Extracted from  : Quercetin is extracted / reported from 104 Plant(s) of Melghat Flora as below

MC005: Cayratia trifolia (L.) Domin.;
MC007: Cardiospermum halicacabum L.;
MC013: Bauhinia vahlii Wight & Arn.;
MC023: Argyreia nervosa (Burm. f.) Bojer;
MH008: Cleome viscosa L.;
MH014: Portulaca oleracea L.;
MH021: Melochia corchorifolia L.;
MH022: Corchorus aestuans L.;
MH023: Corchorus fascicularis Lam.;
MH024: Corchorus olitorius L.;
MH028: Tribulus terrestris L.;
MH032: Impatiens balsamina L.;
MH060: Pseudarthria viscida (L.)Wight & Arn.;
MH067: Vigna radiata (L.) R. Wilczek;
MH068: Vigna trilobata (L.)Verdc.;
MH070: Cassia absus L.;
MH075: Drosera indica L.;
MH076: Ammannia baccifera L. ;
MH080: Ludwigia perennis L.;
MH087: Trianthema portulacastrum L.;
MH099: Ageratum conyzoides L. ;
MH132: Sonchus oleraceus L.;
MH137: Tridax procumbens (L.) L.;
MH159: Convolvulus arvensis L;
MH164: Ipomoea pes-tigridis L.;
MH168: Cuscuta chinensis Lam. ;
MH169: Cuscuta reflexa Roxb. ;
MH196: Blepharis maderaspatensis (L.) Heyne ex Roth.;
MH236: Aerva lanata (L.) Juss. ex Schult.;
MH239: Amaranthus spinosus L.;
MH247: Polygonum glabrum Willd.;
MH248: Polygonum plebeium R. Br. ;
MH249: Rumex dentatus L.;
MH257: Euphorbia geniculata Ortega;
MH259: Euphorbia neriifolia L.;
MH261: Euphorbia prostrata Aiton;
MH262: Euphorbia thymifolia L. ;
MH267: Pilea microphylla (L.) Liebm.;
MH270: Phyllanthus urinaria L. ;
MH327: Amorphophallus paeoniifolius (Dennst.) Nicolson;
MH337: Anagallis arvensis L.;
MH361: Conyza canadensis (L.) Cronquist;
MH383: Phyllanthus amarus Schum & Thonn.;
MH401: Hydrolea zeylanica (L.) Vahl;
MH403: Rorippa indica (L.) Hiern. ;
MH413: Melilotus indica (L.) All.;
MH416: Rotala rotundifolia (Roxb.) Koehne;
MH422: Chenopodium album L.;
MO011: Eulophia ochreata Lindl.;
MS014: Urena lobata L.;
MS017: Waltheria americana L.;
MS030: Aeschynomene indica L.;
MS032: Crotalaria juncea L.;
MS033: Crotalaria retusa L.;
MS045: Tephrosia purpurea (L.) Pers.;
MS048: Caesalpinia decapetala (Roth) Alston;
MS054: Ludwigia octovalvis (Jacq.) P.H. Raven;
MS062: Maesa indica (Roxb.) A. DC.;
MS076: Barleria cristata L.;
MS082: Clerodendrum viscosum Vent.;
MS091: Dendrophthoe falcata (L.f.) Ettingsh.;
MS097: Securinega virosa (Roxb. ex Willd.) Baill.;
MS098: Asparagus racemosus Willd.;
MS101: Solanum torvum Sw.;
MS119: Commiphora wightii (Arn.) Bhandari;
MS120: Dichrostachys cinerea (L.)Wight & Arn.;
MT001: Annona squamosa Linn;
MT003: Cochlospermum religiosum (L.) Alston;
MT006: Flacourtia indica (Burm. f.) Merr.;
MT008: Thespesia populnea (L.) Sol. ex Corra;
MT009: Bombax ceiba L.;
MT018: Soymida febrifuga (Roxb.) Juss.;
MT020: Ziziphus mauritiana Lam.;
MT021: Ziziphus xylopyrus (Retz.) Willd.;
MT022: Ziziphus rugosa Lam.;
MT024: Buchanania cochinchinensis (Lour.) Almeida;
MT025: Lannea coromandelica (Houtt.) Merr.;
MT036: Bauhinia malabarica Roxb.;
MT038: Bauhinia racemosa Lam.;
MT042: Acacia catechu (L.f.) Willd.;
MT043: Albizia lebbeck (L.) Benth.;
MT048: Terminalia arjuna (Roxb.) Wight & Arn.;
MT051: Syzygium cumini (L.) Skeels;
MT052: Eugenia jambolana Lam.;
MT054: Careya arborea Roxb.;
MT062: Madhuca indica J.F. Gmel.;
MT068: Cordia dichotoma Forster. f., Prodr.;
MT078: Emblica officinalis Gaertn.;
MT085: Ficus benghalensis L.;
MT086: Ficus cunia Buch.-Ham. ex Roxb.;
MT089: Ficus religiosa L.;
MT090: Ficus virens W. T. Aiton ;
MT091: Phoenix sylvestris (L.) Roxb.;
MT095: Magnolia champaca (L.) Baill. ex Pierre.;
MT099: Sapindus laurifolius Vahl;
MT100: Acacia chundra (Rottler)Willd.;
MT105: Anacardium occidentale L.;
MT122: Mimusops elengi L.;
MT123: Moringa oleifera Lam;
MT125: Mussaenda frondosa L.;
MT126: Pithecellobium dulce (Roxb.)Benth.;
MT127: Prunus persica (L.) Stokes;
MT130: Quercus incana W. Bartram;
MT134: Sapium sebiferum (L.) Dum.Cours.;

 
 
Molecular Formula  :

C15H10O7
 
  Molecular Weight  : 302.238  
  InChi Key  :  
  IUPAC  :  
  InChi  :  
  Hydrogen Bond Donor count  : 5  
  Hydrogen Bond Acceptor count  : 7  
  Rotational Bond count  : 1  
  TPSA  : 127  
  LogP Value  :

1.5

 
 
Lipinski Rule of Five  :

Yes
 
  Ghose Filter  : Yes  
  Veber Filter  : Yes  
  Muegge Filter  :

Yes

 
 
PubChem CID  :

5280343
 
  Drugbank ID  : DB12937  
  Super Natural  : 000117395  
  CTD  : D011794  
  HIT  : C0183  
  NCI-60 GI50 data  :

117-39-5

 
 
Reference(s)  :



 

Compound_ID Cell Lines Cancer Type IC50 Value EC50 Value ED50 Value GI50 Value References
MMP-AC0008 H-441 - 0.72 µM - - - 9224209
MMP-AC0008 26-L5 Colon 23.9 µg/ml - - - 11411569
MMP-AC0008 L929 Connective tissue - 26±6 µM - - 12628514
MMP-AC0008 L929 Connective tissue - 20±4 µM - - 12628514
MMP-AC0008 CCRF-HSB-2 Haematopoietic and Lymphoid tissue 7.2 µM - - - 10380632
MMP-AC0008 H-661 Haematopoietic and Lymphoid tissue 2.28 µM - - - 9224209
MMP-AC0008 HL-60 Haematopoietic and Lymphoid tissue 31 µM (cc-50) - - - 16158945
MMP-AC0008 HL-60 Haematopoietic and Lymphoid tissue >100 µM - - - 12628514
MMP-AC0008 HSC-2 Head and Neck 35 µM (cc-50) - - - 16158945
MMP-AC0008 Hepa 1c1c7 Liver 14 µM - - - 12628514
MMP-AC0008 A549 Lung 10.0 µM - - - 10380632
MMP-AC0008 A549 Lung 0.78 µM - - - 9224209
MMP-AC0008 ChaGo-K-1 Lung 0.57 µM - - - 9224209
MMP-AC0008 SK-LU1 Lung 0.45 µM - - - 9224209
MMP-AC0008 SW-900 Lung 0.61 µM - - - 9224209
MMP-AC0008 HSC-3 Oral 250 µM (cc-50) - - - 16158945
MMP-AC0008 HSG Salivary duct 745 µM (cc-50) - - - 16158945
MMP-AC0008 B16 melanoma 4A5 Skin - - - - 10380632
MMP-AC0008 MDA-MB-435 Skin 4.58±0.73 µg/ml - - - 17172819
MMP-AC0008 TGBC11TKB Stomach 5.9 µM - - - 10380632

Compound_ID Target Gene_Name Gene_ID Cancer Cell_lines IC50 Value EC50 Value ED50 Value GI50 Value Remarks References
MMP-AC0008 AKT1 v-akt murine thymoma viral oncogene homolog 1 207 Epidermal Carcinoma A431-III - - - - Quercetin was able to directly inhibit the phosphorylation of Akt and thus reduce phosphorylation of GSK3b by 43% on treatment with Qu. 21752154
MMP-AC0008 CCND1 cyclin D1 595 Colon carcinogenesis - - - - - Positive Cyclin D1 expression was detected in mice on diets supplemented by quercetin(P<0.001). Supplementation of quercetin in a standard diet result in the expression of Cyclin D1 in normal colonic cells. 10964096