Compound_ID |
Target |
Gene_Name |
Gene_ID |
Cancer |
Cell_lines |
IC50 Value |
EC50 Value |
ED50 Value |
GI50 Value |
Remarks |
References |
MMP-AC0084 |
AKT1 |
v-akt murine thymoma viral oncogene homolog 1 |
207 |
Breast adenocarcinoma |
MCF-7 |
- |
- |
- |
- |
constitutive activation of AKT was suppressed by beta-caryophyllene oxide in a concentration-dependent manner |
21924548 |
MMP-AC0084 |
AKT1 |
v-akt murine thymoma viral oncogene homolog 1 |
207 |
Prostate Cancer |
PC-3 |
- |
- |
- |
- |
constitutive activation of AKT was suppressed by beta-caryophyllene oxide in a concentration-dependent manner |
21924548 |
MMP-AC0084 |
CASP3 |
caspase 3, apoptosis-related cysteine peptidase |
836 |
Prostate Cancer |
PC-3 |
- |
- |
- |
- |
beta-caryophyllene oxideclearly induced the cleavage of procaspase-3 as observed by the disappearance of the procaspase-3 band and appearance of its cleaved forms. |
21924548 |
MMP-AC0084 |
CCND1 |
cyclin D1 |
595 |
Prostate Cancer |
PC-3 |
- |
- |
- |
- |
beta-caryophyllene oxide suppressed the expression of anti-apoptotic gene products in a concentration-dependent manner. beta-caryophyllene oxide repressed cell cycle protein (Cyclin D1) |
21924548 |
MMP-AC0084 |
CDKN1A |
cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
1026 |
Prostate Cancer |
PC-3 |
- |
- |
- |
- |
beta-caryophyllene oxide induced the expression of p21 in a concentration-dependent manner in prostate tumor cells |
21924548 |
MMP-AC0084 |
COX-2 |
cytochrome c oxidase subunit II |
4513 |
Prostate Cancer |
PC-3 |
- |
- |
- |
- |
beta-caryophyllene oxide suppressed the expression of anti-apoptotic gene products in a concentration-dependent manner. beta-caryophyllene oxide repressed proteins linked with metastasis i.e. COX-2 |
21924548 |
MMP-AC0084 |
MAPK1 |
mitogen-activated protein kinase 1 |
5594 |
Breast adenocarcinoma |
MCF-7 |
- |
- |
- |
- |
beta-caryophyllene oxide slightly upregulated the phosphorylation of p38 MAPK in the cancer cells. |
21924548 |
MMP-AC0084 |
MAPK1 |
mitogen-activated protein kinase 1 |
5594 |
Prostate Cancer |
PC-3 |
- |
- |
- |
- |
beta-caryophyllene oxide slightly upregulated the phosphorylation of p38 MAPK in the PC-3 cancer cells. |
21924548 |
MMP-AC0084 |
MAPK8 |
mitogen-activated protein kinase 8 |
5599 |
Breast adenocarcinoma |
MCF-7 |
- |
- |
- |
- |
beta-caryophyllene oxide slightly upregulated the phosphorylation of JNK in the MCF-7 cancer cells. |
21924548 |
MMP-AC0084 |
MTOR |
mechanistic target of rapamycin (serine/threonine kinase) |
2475 |
Breast adenocarcinoma |
MCF-7 |
- |
- |
- |
- |
constitutive activation of mTOR was suppressed by beta-caryophyllene oxide in a concentration-dependent manner |
21924548 |
MMP-AC0084 |
PARP1 |
poly (ADP-ribose) polymerase 1 |
142 |
Prostate Cancer |
PC-3 |
- |
- |
- |
- |
beta-caryophyllene oxide induced PARP cleavage in a concentration-dependent manner |
21924548 |
MMP-AC0084 |
PIK3CA |
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha |
5290 |
Breast adenocarcinoma |
MCF-7 |
- |
- |
- |
- |
constitutive activation of PI3K was suppressed by beta-caryophyllene oxide in a concentration-dependent manner |
21924548 |
MMP-AC0084 |
PIK3CA |
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha |
5290 |
Prostate Cancer |
PC-3 |
- |
- |
- |
- |
constitutive activation of PI3K was suppressed by beta-caryophyllene oxide in a concentration-dependent manner |
21924548 |
MMP-AC0084 |
RPS6KB1 |
ribosomal protein S6 kinase, 70kDa, polypeptide 1 |
6198 |
Breast adenocarcinoma |
MCF-7 |
- |
- |
- |
- |
constitutive activation of S6K1 was suppressed by beta-caryophyllene oxide in a concentration-dependent manner |
21924548 |
MMP-AC0084 |
TP53 |
tumor protein p53 |
7157 |
Prostate Cancer |
PC-3 |
- |
- |
- |
- |
beta-caryophyllene oxide induced the expression of p53 in a concentration-dependent manner in prostate tumor cells |
21924548 |
MMP-AC0084 |
VEGFA |
vascular endothelial growth factor A |
7422 |
Prostate Cancer |
PC-3 |
- |
- |
- |
- |
beta-caryophyllene oxide suppressed the expression of anti-apoptotic gene products in a concentration-dependent manner. beta-caryophyllene oxide repressed proteins linked with angiogenesis i.e. VEGF |
21924548 |