Falcarinol | MMP-AC0185

	Compound Name :	Falcarinol
	Compound Class :	Aliphatic natural products
	Synonyms :	Falcarinol; 21852-80-2; Panaxynol; (3R,9Z)-heptadeca-1,9-dien-4,6-diyn-3-ol; CHEBI:66722;
	Compound Extracted from :	Falcarinol is extracted / reported from 1 Plant(s) of Melghat Flora as below MH356: Apium graveolens Linn.;

	Molecular Formula :	C17H24O
	Molecular Weight :	244.37
	InChi Key :	UGJAEDFOKNAMQD-QXPKXGMISA-N
	IUPAC :	(3R,9Z)-heptadeca-1,9-dien-4,6-diyn-3-ol
	InChi :	InChI=1S/C17H24O/c1-3-5-6-7-8-9-10-11-12-13-14-15-16-17(18)4-2/h4,10-11,17-18H,2-3,5-9,12H2,1H3/b11-10-/t17-/m1/s1
	Hydrogen Bond Donor count :	1
	Hydrogen Bond Acceptor count :	1
	Rotational Bond count :	9
	TPSA :	20.2
	LogP Value :	5.5

	Lipinski Rule of Five :	No
	Ghose Filter :	Yes
	Veber Filter :	No
	Muegge Filter :	No

	PubChem CID :	5281149
	Drugbank ID :	-
	Super Natural :	055297875
	CTD :	C018541
	HIT :	C0094
	NCI-60 GI50 data :	-

	Reference(s) :	https://pubchem.ncbi.nlm.nih.gov/compound/5281149

Compound_ID	Cell Lines	Cancer Type	IC50 Value	EC50 Value	ED50 Value	GI50 Value	References
MMP-AC0185	NCI-60	-	-	-	-	0.00000022 M	8792622

Compound_ID	Target	Gene_Name	Gene_ID	Cancer	Cell_lines	IC50 Value	EC50 Value	ED50 Value	GI50 Value	Remarks	References
MMP-AC0185	CASP3	caspase 3, apoptosis-related cysteine peptidase	836	Colorectal Adenocarcinoma	CaCo-2	-	-	-	-	At concentrations above 20 然 falcarinol, proliferation of CaCo-2 cells decreased and the number of cells expressing active caspase-3 increased simultaneously with increased cell detachment. the effects of falcarinol on CaCo-2 cells appear to be biphasic, inducing proproliferative and apoptotic characteristics at low and high concentrations of falcarinol, respectively.	17263451

MMP-AC0185 : Falcarinol