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Botanical Name Plant's Common Name Plant Family   

   MMP-AC0226 : Wogonin

 
Compound Name  :
Wogonin		  
  Compound Class  : Flavonoid  
  Synonyms  : 5,7-Dihydroxy-8-methoxyflavone; Vogonin; 4H-1-Benzopyran-4-one, 5,7-dihydroxy-8-methoxy-2-phenyl-Norwogonin 8-methyl ether; 5,7-dihydroxy-8-methoxy-2-phenyl-4H-chromen-4-one; 5,7-dihydroxy-8-methoxy-2-phenylchromen-4-one

  
  Compound Extracted from  : Wogonin is extracted / reported from 2 Plant(s) of Melghat Flora as below


 
 
Molecular Formula  :
C16H12O5		  
  Molecular Weight  : 284.26  
  InChi Key  :  
  IUPAC  :  
  InChi  :  
  Hydrogen Bond Donor count  : 2  
  Hydrogen Bond Acceptor count  : 5  
  Rotational Bond count  : 2  
  TPSA  : 76  
  LogP Value  :

 3

  
 
Lipinski Rule of Five  :
Yes		  
  Ghose Filter  : Yes  
  Veber Filter  : Yes  
  Muegge Filter  :

 Yes

  
 
PubChem CID  :
5281703		  
  Drugbank ID  : -  
  Super Natural  : -  
  CTD  : C085514  
  HIT  : C0014  
  NCI-60 GI50 data  :

 -

  
 
Reference(s)  :
https://pubchem.ncbi.nlm.nih.gov/compound/5281703

  

Compound_ID Cell Lines Cancer Type IC50 Value EC50 Value ED50 Value GI50 Value References
MMP-AC0226 26-L5 Colon 86.9 µg/ml - - - 11411569
MMP-AC0226 26-L5 Colon 26.3 µg/ml - - - 11411569
MMP-AC0226 HT-29 Colon - - 3.35 µg/mL - 9883591
MMP-AC0226 CEM Haematopoietic and Lymphoid tissue 12.3 µM - - - 21776020
MMP-AC0226 CEM Haematopoietic and Lymphoid tissue 0.19 µM - - - 21776020
MMP-AC0226 HL-60 Haematopoietic and Lymphoid tissue - - 4.66 µg/mL - 9883591
MMP-AC0226 P-388 Haematopoietic and Lymphoid tissue - - 1.70 µg/mL - 9883591
MMP-AC0226 A549 Lung - - 4.14 µg/mL - 9883591
MMP-AC0226 KB Nasopharyngeal - - 4.46 µg/mL - 9883591

Compound_ID Target Gene_Name Gene_ID Cancer Cell_lines IC50 Value EC50 Value ED50 Value GI50 Value Remarks References
MMP-AC0226 BCL2-associated X protein 581 sarcoma S180 - - - - After the seven-day treatments by the route of i.v., wogonin (20, 40mg/kg) had significant inhibitory effect on the growth of inoculated S180 in mice. The inhibitory rates was 34.24%.After mice with S180 were treated with wogonin (20,40mg/kg) seven times intravenously,wogonin could increase the levels of bax mRNA and bax protein in a concentration-dependent manner. 16755005
MMP-AC0226 BCL2 B-cell CLL/lymphoma 2 596 sarcoma S180 - - - - After the seven-day treatments by the route of i.v., wogonin (20, 40mg/kg) had significant inhibitory effect on the growth of inoculated S180 in mice. The inhibitory rates was 34.24%. After mice with S180 were treated with wogonin (20,40mg/kg) seven times intravenously,wogonin could lower the level of bcl-2 mRNA and bcl-2 protein. 16755005
MMP-AC0226 CDK7 cyclin-dependent kinase 7 1022 T-cell Leukemia CEM 12.3 µM - - - CDK7 is a component of the transcription factor TFIIH, which phosphorylates Ser5 residues in the heptad repeats of the carboxy-terminal domain (CTD) of RNA polymerase II (RNAPII) to facilitate transcription initiation. 21776020
MMP-AC0226 CDK9 cyclin-dependent kinase 9 1025 T-cell Leukemia CEM 0.19 µM - - - Wogonin preferentially inhibits CDK9 in malignant compared with normal lymphocytes. 21776020
MMP-AC0226 MCL1 myeloid cell leukemia sequence 1 (BCL2-related) 4170 Adult T-cell leukemia (ATL) HTLV-1-SP - - - - Wogonin downregulates Mcl-1 protein expression in malignant cells. 21776020
MMP-AC0226 MCL1 myeloid cell leukemia sequence 1 (BCL2-related) 4170 Colon cancer HCT-116 - - - - Wogonin downregulates Mcl-1 protein expression in malignant cells. 21776020
MMP-AC0226 MCL1 myeloid cell leukemia sequence 1 (BCL2-related) 4170 T-cell Leukemia CEM - - - - Wogonin downregulates Mcl-1 protein expression in malignant cells. 21776020
MMP-AC0226 TP53 tumor protein p53 7157 sarcoma S180 - - - - After the seven-day treatments by the route of i.v., wogonin (20, 40mg/kg) had significant inhibitory effect on the growth of inoculated S180 in mice. The inhibitory rates was 34.24%. After mice with S180 were treated with wogonin (20,40mg/kg) seven times intravenously,wogonin could increase the levels of p53 mRNA dramatically in a concentration-dependent manner. 16755005